Prorenin, its maturation and the (pro)renin receptor

The renin-angiotensin system (RAS) is a key biochemical pathway controlling homeostasis and blood pressure. The initial step of the RAS is carried out by renin to produce angiotensin (Ang) I which is converted to Angll by the angiotensin-converting enzyme (ACE). Renin is synthesized as a pro-enzyme which can be activated in dense core granules of the renal juxtaglomerular cells or released as prorenin. There is evidence that prorenin can, in addition, be activated in a reversible manner, via a prorenin receptor. Recently, a specific (pro)renin receptor was identified in human tissues. Binding ofthis receptor to (pro)renin caused increased cleavage of angiotensinogen and stimulation of an intracellular signalling pathway. The aim of this thesis is to investigate the biology of prorenin, its maturation and the (pro)renin receptor.

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

2007

Author dc:creator

• L'Huillier, Nathalie

Handle dc:identifier.uri

http://hdl.handle.net/1842/29224

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/29224