{"id":{"repo_id":"edinburgh","oai_identifier":"oai:era.ed.ac.uk:1842/27926"},"canonical_url":"https://search.dev.ndltd.org/etd/edinburgh/oai:era.ed.ac.uk:1842/27926","repository":{"repo_id":"edinburgh","name":"University of Edinburgh","base_url":"https://era.ed.ac.uk/server/oai/request"},"display":{"title":"Pathological and therapeutic investigations in tuberculosis: PART I PATHOLOGICAL INVESTIGATION - an investigation into hypersensitivity in tuberculosis as illustrated by the response of the skin, and of the leucocytes of the blood to tubérculin; PART II THERAPEUTIC INVESTIGATION - a clinical evaluation of the use of para-aminosalicylic acid in the treatment of pulmonary tuberculosis.","abstract":"PART I PATHOLOGICAL INVESTIGATION - (a) The disintegration of the neutrophil polymorphnuclear cells of the blood of a tuberculous individual is accelerated (when clotting is prevented.) in vitro by the addition of tuberculin.","abstract_html":"PART I PATHOLOGICAL INVESTIGATION - (a) The disintegration of the neutrophil polymorphnuclear cells of the blood of a tuberculous individual is accelerated (when clotting is prevented.) in vitro by the addition of tuberculin.","abstract_has_math":false,"creators":["Donaldson, Rose Isabella Lyall"],"institution":"The University of Edinburgh","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1949,"date_issued":"1949","date_published":"1949","updated_at":"2026-07-24T02:14:03Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1842/27926","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Donaldson, Rose Isabella Lyall"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-01-31T11:42:45Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-01-31T11:42:45Z"]},{"key":"dc:date.issued","label":"Date","values":["1949"]},{"key":"dc:publisher","label":"Institution","values":["The University of Edinburgh"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["Already catalogued"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD Doctor of Philosophy"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1842/27926"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["PART I PATHOLOGICAL INVESTIGATION - (a) The disintegration of the neutrophil polymorphnuclear cells of the blood of a tuberculous individual is accelerated (when clotting is prevented.) in vitro by the addition of tuberculin.","(b) This acceleration is not related to the degree of skin hypersensitivity to tuberculin demonstrated in the sale individual.","(c) The young polymorph is more susceptible to tuberculin than the more mature cell. This is a tentative conclusion and the subject is worthy of further investigation.","(d) The lymphocytes of a tuberculous individual (within the conditions of this experiment) are much less susceptible to damage by tuberculin.","(e) The action of tuberculin on the monocytes of a tuberculous individual cannot be accurately determined because the number of these cells is too small.","(f) Tuberculin causes swelling and disappearance of the granules, with-eventual disintegration of the nucleus of the neutrophil polymorph from the sensitised body.","(g) Owing to the possibility of unavoidable error, a method involving the differential counting of leucocytes would not appear to be entirely suitable for measuring accurately the cytotoxic effect of tuberculin on the white blood corpuscles.","(h) A method suitable for measuring the cytotoxic action of tuberculin on blood leucocytes in the laboratory of the average hospital has not been evolved.","(i) Heparin in the dilutions used is suitable for an investigation of this nature involving the incubation of blood and the examination of the leucocytes.","(i) If the action of tuberculin on the neutrophil polymorphs is taken as indicating, at least in some part, the systemic response of the body, then the local and systemic responses to tuberculin do not necessarily correspond.","(k) Measurement of the action of tuberculin on tissue cells would probably be a more reliable index to tissue sensitivity than the response of the skin, as it is independent of factors such as circulation known to alter the response of the skin to excitor substances.","(l) This finding may throw some light on the variable results obtained when an attempt has been made to correlate changes in skin sensitivity with the clinical course of the disease in tuberculous patients. Fluctuations in the skin reaction, which take place in the course of the disease, may not necessarily be accompanied by changes in systemic tissue sensitivity.","(m) The ease of performance, however, of the intracutaneous tuberculin test is of considerable importance in assessing its value as a measure of tissue sensitivity.","PART II THERAPEUTIC INVESTIGATION - a) Para- aminosalicylic acid in the form of the sodium para- aminosalicylate salt exerts a beneficial effect in pulmonary tuberculosis.","b) This effect is-greatest in exudative lesions and consists in the promotion of resolution of these lesions.","c) The effect is not of a sufficient degree to alter permanently the course of the disease in the majority of advanced cases.","d) The greatest amount of benefit from P.A.S. occurs in the first three months of treatment.","e) P.A.S. is instrumental in reducing the size of certain cavities. The exact nature of the change which takes place is not known.","f) P.A.S. produces an improvement in the general condition of patients suffering from pulmonary tuberculosis.","g) A marked initial fall occurs in the blood sedimentation rate following the administration of P.A.S. in ,patients suffering from pulmonary tuberculosis.","h) No serious or irreversible toxic effects ensue from the administration of the drug.","i) Within the limits of this uncontrolled study, the effect of P.A.S. is not strikingly related to the length of course, or level of blood concentration obtained.","j) Para- aminosalicylic acid is not a therapeutic agent of the first importance in the treatment of pulmonary tuberculosis, and its value in the future may lie in combination with streptomycin."]},{"key":"dc:title","label":"Title","values":["Pathological and therapeutic investigations in tuberculosis: PART I PATHOLOGICAL INVESTIGATION - an investigation into hypersensitivity in tuberculosis as illustrated by the response of the skin, and of the leucocytes of the blood to tubérculin; PART II THERAPEUTIC INVESTIGATION - a clinical evaluation of the use of para-aminosalicylic acid in the treatment of pulmonary tuberculosis."]}]}],"canonical_facts":{"dc:creator":["Donaldson, Rose Isabella Lyall"],"dc:date.accessioned":["2018-01-31T11:42:45Z"],"dc:date.available":["2018-01-31T11:42:45Z"],"dc:date.issued":["1949"],"dc:description.abstract":["PART I PATHOLOGICAL INVESTIGATION - (a) The disintegration of the neutrophil polymorphnuclear cells of the blood of a tuberculous individual is accelerated (when clotting is prevented.) in vitro by the addition of tuberculin.","(b) This acceleration is not related to the degree of skin hypersensitivity to tuberculin demonstrated in the sale individual.","(c) The young polymorph is more susceptible to tuberculin than the more mature cell. This is a tentative conclusion and the subject is worthy of further investigation.","(d) The lymphocytes of a tuberculous individual (within the conditions of this experiment) are much less susceptible to damage by tuberculin.","(e) The action of tuberculin on the monocytes of a tuberculous individual cannot be accurately determined because the number of these cells is too small.","(f) Tuberculin causes swelling and disappearance of the granules, with-eventual disintegration of the nucleus of the neutrophil polymorph from the sensitised body.","(g) Owing to the possibility of unavoidable error, a method involving the differential counting of leucocytes would not appear to be entirely suitable for measuring accurately the cytotoxic effect of tuberculin on the white blood corpuscles.","(h) A method suitable for measuring the cytotoxic action of tuberculin on blood leucocytes in the laboratory of the average hospital has not been evolved.","(i) Heparin in the dilutions used is suitable for an investigation of this nature involving the incubation of blood and the examination of the leucocytes.","(i) If the action of tuberculin on the neutrophil polymorphs is taken as indicating, at least in some part, the systemic response of the body, then the local and systemic responses to tuberculin do not necessarily correspond.","(k) Measurement of the action of tuberculin on tissue cells would probably be a more reliable index to tissue sensitivity than the response of the skin, as it is independent of factors such as circulation known to alter the response of the skin to excitor substances.","(l) This finding may throw some light on the variable results obtained when an attempt has been made to correlate changes in skin sensitivity with the clinical course of the disease in tuberculous patients. Fluctuations in the skin reaction, which take place in the course of the disease, may not necessarily be accompanied by changes in systemic tissue sensitivity.","(m) The ease of performance, however, of the intracutaneous tuberculin test is of considerable importance in assessing its value as a measure of tissue sensitivity.","PART II THERAPEUTIC INVESTIGATION - a) Para- aminosalicylic acid in the form of the sodium para- aminosalicylate salt exerts a beneficial effect in pulmonary tuberculosis.","b) This effect is-greatest in exudative lesions and consists in the promotion of resolution of these lesions.","c) The effect is not of a sufficient degree to alter permanently the course of the disease in the majority of advanced cases.","d) The greatest amount of benefit from P.A.S. occurs in the first three months of treatment.","e) P.A.S. is instrumental in reducing the size of certain cavities. The exact nature of the change which takes place is not known.","f) P.A.S. produces an improvement in the general condition of patients suffering from pulmonary tuberculosis.","g) A marked initial fall occurs in the blood sedimentation rate following the administration of P.A.S. in ,patients suffering from pulmonary tuberculosis.","h) No serious or irreversible toxic effects ensue from the administration of the drug.","i) Within the limits of this uncontrolled study, the effect of P.A.S. is not strikingly related to the length of course, or level of blood concentration obtained.","j) Para- aminosalicylic acid is not a therapeutic agent of the first importance in the treatment of pulmonary tuberculosis, and its value in the future may lie in combination with streptomycin."],"dc:identifier.uri":["http://hdl.handle.net/1842/27926"],"dc:publisher":["The University of Edinburgh"],"dc:relation.isreferencedby":["Already catalogued"],"dc:title":["Pathological and therapeutic investigations in tuberculosis: PART I PATHOLOGICAL INVESTIGATION - an investigation into hypersensitivity in tuberculosis as illustrated by the response of the skin, and of the leucocytes of the blood to tubérculin; PART II THERAPEUTIC INVESTIGATION - a clinical evaluation of the use of para-aminosalicylic acid in the treatment of pulmonary tuberculosis."],"dc:type":["Thesis or Dissertation"],"dc:type.qualificationname":["PhD Doctor of Philosophy"]},"updated_at":"2026-07-24T02:14:03Z"}