{"id":{"repo_id":"edinburgh","oai_identifier":"oai:era.ed.ac.uk:1842/27899"},"canonical_url":"https://search.dev.ndltd.org/etd/edinburgh/oai:era.ed.ac.uk:1842/27899","repository":{"repo_id":"edinburgh","name":"University of Edinburgh","base_url":"https://era.ed.ac.uk/server/oai/request"},"display":{"title":"Remote, non-invasive ischaemic preconditioning of skeletal muscle flaps against ischaemic necrosis : efficacy and mechanism","abstract":"HYPOTHESIS: That skeletal muscle, throughout the body, can be preconditioned to better withstand prolonged periods of ischaemia, by first subjecting a remote muscle to brief, non-invasive and sub-lethal, cycles of ischaemia and reperfusion, using a hindlimb tourniquet.","abstract_html":"HYPOTHESIS: That skeletal muscle, throughout the body, can be preconditioned to better withstand prolonged periods of ischaemia, by first subjecting a remote muscle to brief, non-invasive and sub-lethal, cycles of ischaemia and reperfusion, using a hindlimb tourniquet.","abstract_has_math":false,"creators":["Addison, Patrick"],"institution":"The University of Edinburgh","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-24T02:14:03Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1842/27899","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Addison, Patrick"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-01-31T11:42:28Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-01-31T11:42:28Z"]},{"key":"dc:date.issued","label":"Date","values":["2006"]},{"key":"dc:publisher","label":"Institution","values":["The University of Edinburgh"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["Already catalogued"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MD Doctor of Medicine"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1842/27899"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["HYPOTHESIS: That skeletal muscle, throughout the body, can be preconditioned to better withstand prolonged periods of ischaemia, by first subjecting a remote muscle to brief, non-invasive and sub-lethal, cycles of ischaemia and reperfusion, using a hindlimb tourniquet.","AIMS: The aims of the project were:","1) To test the hypothesis, using porcine Latissimus Dorsi, Rectus Abdominis and Gracilis muscle flaps.","2) To define the potency and time course of the protective effect of remote ischaemic preconditioning in this model.","3) To assess the physiological effects of remote ischaemic preconditioning both in terms of energy metabolism during subsequent prolonged ischaemia, and postischaemic blood flow","4) To investigate the mechanism of remote ischaemic preconditioning in this model."]},{"key":"dc:title","label":"Title","values":["Remote, non-invasive ischaemic preconditioning of skeletal muscle flaps against ischaemic necrosis : efficacy and mechanism"]}]}],"canonical_facts":{"dc:creator":["Addison, Patrick"],"dc:date.accessioned":["2018-01-31T11:42:28Z"],"dc:date.available":["2018-01-31T11:42:28Z"],"dc:date.issued":["2006"],"dc:description.abstract":["HYPOTHESIS: That skeletal muscle, throughout the body, can be preconditioned to better withstand prolonged periods of ischaemia, by first subjecting a remote muscle to brief, non-invasive and sub-lethal, cycles of ischaemia and reperfusion, using a hindlimb tourniquet.","AIMS: The aims of the project were:","1) To test the hypothesis, using porcine Latissimus Dorsi, Rectus Abdominis and Gracilis muscle flaps.","2) To define the potency and time course of the protective effect of remote ischaemic preconditioning in this model.","3) To assess the physiological effects of remote ischaemic preconditioning both in terms of energy metabolism during subsequent prolonged ischaemia, and postischaemic blood flow","4) To investigate the mechanism of remote ischaemic preconditioning in this model."],"dc:identifier.uri":["http://hdl.handle.net/1842/27899"],"dc:publisher":["The University of Edinburgh"],"dc:relation.isreferencedby":["Already catalogued"],"dc:title":["Remote, non-invasive ischaemic preconditioning of skeletal muscle flaps against ischaemic necrosis : efficacy and mechanism"],"dc:type":["Thesis or Dissertation"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["MD Doctor of Medicine"]},"updated_at":"2026-07-24T02:14:03Z"}