{"id":{"repo_id":"east-anglia","oai_identifier":"oai:ueaeprints.uea.ac.uk:52530"},"canonical_url":"https://search.dev.ndltd.org/etd/east-anglia/oai:ueaeprints.uea.ac.uk:52530","repository":{"repo_id":"east-anglia","name":"University of East Anglia","base_url":"https://ueaeprints.uea.ac.uk/cgi/oai2"},"display":{"title":"A study of the NF-κB signalling pathway in human acute myeloid leukaemia.","abstract":"The transcription factor NF-κB can play both a protective and destructive role in cells. NF-κB protects by signalling for the immune system when cells fall under attack from pathogens. NF-κB signalling becomes a danger to cells when signalling becomes constitutive and can promote excessive inflammation and tumourigenesis. Constitutive NF-κB signalling occurs within acute myeloid leukaemia cells, promoting cell survival. This provides reason to investigate the NF-κB signalling pathway in greater detail. Prevention of NF-κB signalling should lead to cell apoptosis of AML cells but this outcome may be affected by any one of the many signalling components that make up the extremely complex NF-κB signalling pathway. A range of the NF-κB signalling components within AML cells are investigated in detail this study. It was uncovered that although p50 NF-κB levels were consistent in AML and control cell samples, IκB levels were markedly reduced, leading to greater basal NF-κB activity in AML cancer cells compared to control non-cancer cells. Furthermore, this inhibited IκB level observed in AML cells, appeared to be maintained by autocrine TNF production, as anti-TNF treatment impaired the observed response. These findings indicate that IκB levels underlie the high basal NF-κB activity that is observed in AML cancer cells, and possibly other types of NF-κB-dependent cancers. Targetting IκB may help improve cancer chemotherapeutic effectiveness in AML.","abstract_html":"The transcription factor NF-κB can play both a protective and destructive role in cells. NF-κB protects by signalling for the immune system when cells fall under attack from pathogens. NF-κB signalling becomes a danger to cells when signalling becomes constitutive and can promote excessive inflammation and tumourigenesis. Constitutive NF-κB signalling occurs within acute myeloid leukaemia cells, promoting cell survival. This provides reason to investigate the NF-κB signalling pathway in greater detail. Prevention of NF-κB signalling should lead to cell apoptosis of AML cells but this outcome may be affected by any one of the many signalling components that make up the extremely complex NF-κB signalling pathway. A range of the NF-κB signalling components within AML cells are investigated in detail this study. It was uncovered that although p50 NF-κB levels were consistent in AML and control cell samples, IκB levels were markedly reduced, leading to greater basal NF-κB activity in AML cancer cells compared to control non-cancer cells. Furthermore, this inhibited IκB level observed in AML cells, appeared to be maintained by autocrine TNF production, as anti-TNF treatment impaired the observed response. These findings indicate that IκB levels underlie the high basal NF-κB activity that is observed in AML cancer cells, and possibly other types of NF-κB-dependent cancers. Targetting IκB may help improve cancer chemotherapeutic effectiveness in AML.","abstract_has_math":false,"creators":["Hogg, Alison"],"institution":"University of East Anglia","degree_name":"other","degree_level":"masters","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-11","date_published":"2011-11","updated_at":"2026-07-24T02:12:08Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Hogg, Alison"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-11"]},{"key":"dc:date.issued","label":"Date","values":["2011-11"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Pharmacy"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of East Anglia"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://ueaeprints.uea.ac.uk/id/eprint/52530/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["other"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://ueaeprints.uea.ac.uk/id/eprint/52530/1/Alison_Hogg_MSc_thesis.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The transcription factor NF-κB can play both a protective and destructive role in cells. NF-κB protects by signalling for the immune system when cells fall under attack from pathogens. NF-κB signalling becomes a danger to cells when signalling becomes constitutive and can promote excessive inflammation and tumourigenesis. Constitutive NF-κB signalling occurs within acute myeloid leukaemia cells, promoting cell survival. This provides reason to investigate the NF-κB signalling pathway in greater detail. Prevention of NF-κB signalling should lead to cell apoptosis of AML cells but this outcome may be affected by any one of the many signalling components that make up the extremely complex NF-κB signalling pathway. A range of the NF-κB signalling components within AML cells are investigated in detail this study. It was uncovered that although p50 NF-κB levels were consistent in AML and control cell samples, IκB levels were markedly reduced, leading to greater basal NF-κB activity in AML cancer cells compared to control non-cancer cells. Furthermore, this inhibited IκB level observed in AML cells, appeared to be maintained by autocrine TNF production, as anti-TNF treatment impaired the observed response. These findings indicate that IκB levels underlie the high basal NF-κB activity that is observed in AML cancer cells, and possibly other types of NF-κB-dependent cancers. Targetting IκB may help improve cancer chemotherapeutic effectiveness in AML."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["A study of the NF-κB signalling pathway in human acute myeloid leukaemia."]}]}],"canonical_facts":{"dc:creator":["Hogg, Alison"],"dc:date":["2011-11"],"dc:date.issued":["2011-11"],"dc:description.abstract":["The transcription factor NF-κB can play both a protective and destructive role in cells. NF-κB protects by signalling for the immune system when cells fall under attack from pathogens. NF-κB signalling becomes a danger to cells when signalling becomes constitutive and can promote excessive inflammation and tumourigenesis. Constitutive NF-κB signalling occurs within acute myeloid leukaemia cells, promoting cell survival. This provides reason to investigate the NF-κB signalling pathway in greater detail. Prevention of NF-κB signalling should lead to cell apoptosis of AML cells but this outcome may be affected by any one of the many signalling components that make up the extremely complex NF-κB signalling pathway. A range of the NF-κB signalling components within AML cells are investigated in detail this study. It was uncovered that although p50 NF-κB levels were consistent in AML and control cell samples, IκB levels were markedly reduced, leading to greater basal NF-κB activity in AML cancer cells compared to control non-cancer cells. Furthermore, this inhibited IκB level observed in AML cells, appeared to be maintained by autocrine TNF production, as anti-TNF treatment impaired the observed response. These findings indicate that IκB levels underlie the high basal NF-κB activity that is observed in AML cancer cells, and possibly other types of NF-κB-dependent cancers. Targetting IκB may help improve cancer chemotherapeutic effectiveness in AML."],"dc:format":["application/pdf"],"dc:identifier.uri":["https://ueaeprints.uea.ac.uk/id/eprint/52530/1/Alison_Hogg_MSc_thesis.pdf"],"dc:language":["en"],"dc:publisher.department":["School of Pharmacy"],"dc:publisher.institution":["University of East Anglia"],"dc:relation.isreferencedby":["https://ueaeprints.uea.ac.uk/id/eprint/52530/"],"dc:title":["A study of the NF-κB signalling pathway in human acute myeloid leukaemia."],"dc:type":["Thesis"],"dc:type.qualificationlevel":["masters"],"dc:type.qualificationname":["other"]},"updated_at":"2026-07-24T02:12:08Z"}