Synthesis of Novel Calix[4]arene Based Dendrimers and their Biological Applications

This thesis describes the development and synthesis of multicalixarenes and their application in gene and drug delivery. Chapter 1 provides an introduction to gene therapy and calixarenes. The synthesis of two families of amino functionalised multicalixarenes are described. Evaluation of their toxicity and transfection studies are reported and a number of candidates for development identified. Chapter 2 describes the development of calixarene glycoconjugates using a wide range of approaches. The synthesis of calixarene glycoconjugates through click chemistry is reported and the development of the first multicalixarene glycoconjugate is discussed. Chapter 3 reviews the development of large multicalixarenes assemblies. The synthesis of large (9 and 21 member) click based multicalixarenes is described.

Name dc:type.qualificationname

phd

Level dc:type.qualificationlevel

doctoral

Grantor dc:publisher.institution

University of East Anglia

Year dc:date.issued

2013

Author dc:creator

• Atzori, Simone

Language dc:language

en