Synthesis of Bicyclic Thieno[2,3-d]Pyrimidines, Tricyclic Thieno[2,3-d]Pyrimidines and Thieno[3,2-d]Pyrimidines as Classical and Nonclassical Antifolates

An introduction, background and research progress in the areas of antifolates and antimitotic agents has been reviewed and discussed. Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer chemotherapy and the treatment of infectious diseases. As a part of this study, thirty-five novel compounds were designed and synthesized on the basis of existing clinically active compounds and their crystal structures. These compounds were synthesized and evaluated as single and/or muliple targeted classical and nonclassical antifolates to decrease toxicity and improve the antitumor activity and selectivity of existing therapeutic agents. In addition, bicyclic substituted thieno[2, 3- italic d /italic ]- and theino[3, 2- italic d /italic ]pyrimidines were synthesized as antimitotic agents. These compounds allowed potent inhibition of tumor cells in culture and extended the structure-activity relationship in the antimitotic area.

Name thesis:degree_name

MS

Level thesis:degree_level

Immediate Access

Discipline thesis:degree_discipline

Medicinal Chemistry

Year dc:date.available

2012

Author dc:creator

• Zhou, Xilin

Contributors dc:contributor

• Aleem Gangjee
• Patrick Flaherty
• David Lapinsky

• Antifolate
• Drug design
• SAR

Language dc:language

English

Repository record dc:identifier

https://dsc.duq.edu/etd/1413

OAI identifier oai:identifier

oai:dsc.duq.edu:etd-2429