{"id":{"repo_id":"dundee","oai_identifier":"oai:discovery.dundee.ac.uk:studenttheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f"},"canonical_url":"https://search.dev.ndltd.org/etd/dundee/oai:discovery.dundee.ac.uk:studenttheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f","repository":{"repo_id":"dundee","name":"University of Dundee","base_url":"https://discovery.dundee.ac.uk/ws/oai"},"display":{"title":"Development of Ultrasonic Devices for Microparticle and Cell Manipulation","abstract":"An emerging demand for the precise manipulation of cells and microparticles for applications in cell biology and analytical chemistry has driven recent development of ultrasonic manipulation technology. Compared to the other major technologies used for cell and particle manipulation, such as magnetic tweezing, optical tweezing and dielectrophoresis, ultrasonic manipulation has shown excellent capabilities and flexibility in a variety of applications with its advantages of versatile, inexpensive and easy integration into microfluidic systems, maintenance of cell viability, and generation of sufficient forces to handle cells with dimensions up to tens of microns and agglomerates of a large number of cells.
This thesis reviews current state-of-the-art of ultrasonic manipulation technology and reports the development of various ultrasonic manipulation devices, including simple devices integrated with high frequency (> 20 MHz) ultrasonic transducers for the investigation of biological cells and complex ultrasonic transducer array systems to explore the feasibility of electronically controlled 2-D and 3-D manipulation. Piezoelectric and passive materials, fabrication techniques, characterisation methods and possible applications are discussed. The behaviour and performance of the devices have been investigated and predicted in virtual prototyping with computer simulations, and verified experimentally. Issues associated during the development are highlighted and discussed. To assist long term practical adoption, approaches to low-cost, wafer level batch-production and commercialisation potential are also addressed.","abstract_html":"An emerging demand for the precise manipulation of cells and microparticles for applications in cell biology and analytical chemistry has driven recent development of ultrasonic manipulation technology. Compared to the other major technologies used for cell and particle manipulation, such as magnetic tweezing, optical tweezing and dielectrophoresis, ultrasonic manipulation has shown excellent capabilities and flexibility in a variety of applications with its advantages of versatile, inexpensive and easy integration into microfluidic systems, maintenance of cell viability, and generation of sufficient forces to handle cells with dimensions up to tens of microns and agglomerates of a large number of cells.<br/><br/>This thesis reviews current state-of-the-art of ultrasonic manipulation technology and reports the development of various ultrasonic manipulation devices, including simple devices integrated with high frequency (> 20 MHz) ultrasonic transducers for the investigation of biological cells and complex ultrasonic transducer array systems to explore the feasibility of electronically controlled 2-D and 3-D manipulation. Piezoelectric and passive materials, fabrication techniques, characterisation methods and possible applications are discussed. The behaviour and performance of the devices have been investigated and predicted in virtual prototyping with computer simulations, and verified experimentally. Issues associated during the development are highlighted and discussed. To assist long term practical adoption, approaches to low-cost, wafer level batch-production and commercialisation potential are also addressed.","abstract_has_math":false,"creators":["Qiu, Yongqiang"],"institution":"University of Dundee","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Huang, Zhihong"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-24T02:07:59Z","subjects":["Ultrasonic manipulation","Transducer arrays","Finite element analysis","Microfabrication"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:discovery.dundee.ac.uk:studenttheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f"],"render_values":[{"text":"oai:discovery.dundee.ac.uk:studenttheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f","href":null,"code":true}]}]},"links":{"outbound_url":"https://discovery.dundee.ac.uk/en/studentTheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Huang, Zhihong"]},{"key":"dc:creator","label":"Author","values":["Qiu, Yongqiang"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Mechanical Engineering & Mechatronics"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Dundee"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://discovery.dundee.ac.uk/en/studentTheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Ultrasonic manipulation","Transducer arrays","Finite element analysis","Microfabrication"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:discovery.dundee.ac.uk:studenttheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f","https://discovery.dundee.ac.uk/en/studentTheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://discovery.dundee.ac.uk/files/5518804/Qiu_phd_2014.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["An emerging demand for the precise manipulation of cells and microparticles for applications in cell biology and analytical chemistry has driven recent development of ultrasonic manipulation technology. Compared to the other major technologies used for cell and particle manipulation, such as magnetic tweezing, optical tweezing and dielectrophoresis, ultrasonic manipulation has shown excellent capabilities and flexibility in a variety of applications with its advantages of versatile, inexpensive and easy integration into microfluidic systems, maintenance of cell viability, and generation of sufficient forces to handle cells with dimensions up to tens of microns and agglomerates of a large number of cells.
This thesis reviews current state-of-the-art of ultrasonic manipulation technology and reports the development of various ultrasonic manipulation devices, including simple devices integrated with high frequency (> 20 MHz) ultrasonic transducers for the investigation of biological cells and complex ultrasonic transducer array systems to explore the feasibility of electronically controlled 2-D and 3-D manipulation. Piezoelectric and passive materials, fabrication techniques, characterisation methods and possible applications are discussed. The behaviour and performance of the devices have been investigated and predicted in virtual prototyping with computer simulations, and verified experimentally. Issues associated during the development are highlighted and discussed. To assist long term practical adoption, approaches to low-cost, wafer level batch-production and commercialisation potential are also addressed."]},{"key":"dc:title","label":"Title","values":["Development of Ultrasonic Devices for Microparticle and Cell Manipulation"]}]}],"canonical_facts":{"dc:contributor.advisor":["Huang, Zhihong"],"dc:creator":["Qiu, Yongqiang"],"dc:date":["2014"],"dc:date.issued":["2014"],"dc:description.abstract":["An emerging demand for the precise manipulation of cells and microparticles for applications in cell biology and analytical chemistry has driven recent development of ultrasonic manipulation technology. Compared to the other major technologies used for cell and particle manipulation, such as magnetic tweezing, optical tweezing and dielectrophoresis, ultrasonic manipulation has shown excellent capabilities and flexibility in a variety of applications with its advantages of versatile, inexpensive and easy integration into microfluidic systems, maintenance of cell viability, and generation of sufficient forces to handle cells with dimensions up to tens of microns and agglomerates of a large number of cells.
This thesis reviews current state-of-the-art of ultrasonic manipulation technology and reports the development of various ultrasonic manipulation devices, including simple devices integrated with high frequency (> 20 MHz) ultrasonic transducers for the investigation of biological cells and complex ultrasonic transducer array systems to explore the feasibility of electronically controlled 2-D and 3-D manipulation. Piezoelectric and passive materials, fabrication techniques, characterisation methods and possible applications are discussed. The behaviour and performance of the devices have been investigated and predicted in virtual prototyping with computer simulations, and verified experimentally. Issues associated during the development are highlighted and discussed. To assist long term practical adoption, approaches to low-cost, wafer level batch-production and commercialisation potential are also addressed."],"dc:identifier":["oai:discovery.dundee.ac.uk:studenttheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f","https://discovery.dundee.ac.uk/en/studentTheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f"],"dc:identifier.uri":["https://discovery.dundee.ac.uk/files/5518804/Qiu_phd_2014.pdf"],"dc:language":["eng"],"dc:publisher.department":["Mechanical Engineering & Mechatronics"],"dc:publisher.institution":["University of Dundee"],"dc:relation.isreferencedby":["https://discovery.dundee.ac.uk/en/studentTheses/d66f09c0-c316-4483-b65e-4f3016ce0c9f"],"dc:subject":["Ultrasonic manipulation","Transducer arrays","Finite element analysis","Microfabrication"],"dc:title":["Development of Ultrasonic Devices for Microparticle and Cell Manipulation"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["Doctoral Thesis"],"dc:type.qualificationname":["Doctor of Philosophy"]},"updated_at":"2026-07-24T02:07:59Z"}