Verification of the Ex Vivo Thiel Embalmed Model for Liver Treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS) before Clinical Practice
type: CreativeWork
description: Liver treatment is technically demanding due to the breathing motion and the presence of the ribcage around it, and non-invasive options are desirable. Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is a promising treatment option due to its non-invasive nature and due to the ability to perform MR Thermometry. Thermometry can provide real-time temperature feedback and temperature maps indicating the ablated area. Despite considerable research on liver treatment with MRgFUS, developing a repeatable, safe and efficient ex vivo liver model has not been achieved. The Thiel embalmed model is more favourable than the fresh or formalin-fixed cadavers, due to its long-lasting, tissue-mimicking properties, and limited health risks. This thesis verified the Thiel embalmed liver, as a model for MRgFUS treatment before clinical practice, by using explanted organs and whole cadavers. The first set of experiments involved the measurement of acoustic parameters of Thiel embalmed tissue, and the scrutiny on the temperature response of the embalmed liver on FUS heating. Secondly, baseline phase-referenced Proton Resonance Frequency (PRF) MR Thermometry method was applied on Thiel liver to measure its thermal property (PRF coefficient). By this, the accurate temperature monitoring can be achieved on Thiel tissue. Thirdly, it was examined if the Thiel model is suitable to perform of reference-less PRF Thermometry during MRgFUS sonication. Fourthly, the MRgFUS sonication was performed on explanted liver and on whole human cadaver, in real-patient conditions. These conditions involved vascular visualization (with contrast agent), perfusion, respiratory motion, MR imaging and FUS heating under real-time temperature mapping. The results demonstrate that the acoustic parameters of the Thiel embalmed liver were different from the fresh liver, meaning that more acoustic power needs to be delivered to the target, to achieve ablative levels. Additionally, embalming with Thiel solution a…
abstract: Liver treatment is technically demanding due to the breathing motion and the presence of the ribcage around it, and non-invasive options are desirable. Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is a promising treatment option due to its non-invasive nature and due to the ability to perform MR Thermometry. Thermometry can provide real-time temperature feedback and temperature maps indicating the ablated area. Despite considerable research on liver treatment with MRgFUS, developing a repeatable, safe and efficient ex vivo liver model has not been achieved. The Thiel embalmed model is more favourable than the fresh or formalin-fixed cadavers, due to its long-lasting, tissue-mimicking properties, and limited health risks. This thesis verified the Thiel embalmed liver, as a model for MRgFUS treatment before clinical practice, by using explanted organs and whole cadavers. The first set of experiments involved the measurement of acoustic parameters of Thiel embalmed tissue, and the scrutiny on the temperature response of the embalmed liver on FUS heating. Secondly, baseline phase-referenced Proton Resonance Frequency (PRF) MR Thermometry method was applied on Thiel liver to measure its thermal property (PRF coefficient). By this, the accurate temperature monitoring can be achieved on Thiel tissue. Thirdly, it was examined if the Thiel model is suitable to perform of reference-less PRF Thermometry during MRgFUS sonication. Fourthly, the MRgFUS sonication was performed on explanted liver and on whole human cadaver, in real-patient conditions. These conditions involved vascular visualization (with contrast agent), perfusion, respiratory motion, MR imaging and FUS heating under real-time temperature mapping. The results demonstrate that the acoustic parameters of the Thiel embalmed liver were different from the fresh liver, meaning that more acoustic power needs to be delivered to the target, to achieve ablative levels. Additionally, embalming with Thiel solution a…
author: Karakitsios, Ioannis
language: eng
date published: 2015
date modified: 2026-07-24T02:08:12Z
provider: University of Dundee
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Dundee