Genetic factors associated with neuropathic pain
type: CreativeWork
description: Background and Aim: Neuropathic pain (NP) is a common chronic pain state, affecting approximately 7-10% of the general population. NP is multifactorial, with evidence of both genetic and environmental factors contributing to its development. Although the genetic contribution to NP susceptibility has been recognised in recent decades, the underlying mechanism remains elusive. The aim of this research was to identify genetic variants associated with NP susceptibility. Methods: Firstly, a comprehensive systematic review and meta-analysis of all published human genetic association studies of NP was conducted using electronic literature databases. Secondly, a discovery genome-wide association study (GWAS) of NP was performed in Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) and replication of significant findings was tested in United Kingdom Biobank (UKBB) cohort using dispensed medication records. Thirdly, NP cases and non-NP (NNP), and no-pain controls were identified based on an internationally agreed NP phenotyping method, using self-completed questionnaires from GoDARTS and Generation Scotland: Scottish Family Health Study (GS:SFHS) participants. A two-stage meta-analysis of discovery GWAS (GODARTS and GS:SFHS) was performed in study-I, comparing possible NP cases and NNP controls using a linear mixed model. Then, results were combined with GWAS from UKBB. Similarly, a two-stage meta-analysis of GWAS was conducted comparing NP cases and no pain controls in study-II. Subsequently, previously known variants were tested for replication in these study populations. A post-GWAS analysis was performed in all studies using bioinformatics resources. Finally, replication analysis of prior SNPs associated with NP was performed using diabetic NP cases and controls from GoDARTS. Results: The systematic review identified twenty-nine published human genetic studies, includes molecular genetics and genetic association studies, on NP in different populations b…
abstract: Background and Aim: Neuropathic pain (NP) is a common chronic pain state, affecting approximately 7-10% of the general population. NP is multifactorial, with evidence of both genetic and environmental factors contributing to its development. Although the genetic contribution to NP susceptibility has been recognised in recent decades, the underlying mechanism remains elusive. The aim of this research was to identify genetic variants associated with NP susceptibility. Methods: Firstly, a comprehensive systematic review and meta-analysis of all published human genetic association studies of NP was conducted using electronic literature databases. Secondly, a discovery genome-wide association study (GWAS) of NP was performed in Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) and replication of significant findings was tested in United Kingdom Biobank (UKBB) cohort using dispensed medication records. Thirdly, NP cases and non-NP (NNP), and no-pain controls were identified based on an internationally agreed NP phenotyping method, using self-completed questionnaires from GoDARTS and Generation Scotland: Scottish Family Health Study (GS:SFHS) participants. A two-stage meta-analysis of discovery GWAS (GODARTS and GS:SFHS) was performed in study-I, comparing possible NP cases and NNP controls using a linear mixed model. Then, results were combined with GWAS from UKBB. Similarly, a two-stage meta-analysis of GWAS was conducted comparing NP cases and no pain controls in study-II. Subsequently, previously known variants were tested for replication in these study populations. A post-GWAS analysis was performed in all studies using bioinformatics resources. Finally, replication analysis of prior SNPs associated with NP was performed using diabetic NP cases and controls from GoDARTS. Results: The systematic review identified twenty-nine published human genetic studies, includes molecular genetics and genetic association studies, on NP in different populations b…
author: Veluchamy, Abirami
language: eng
keywords: Neuropathic pain, Genetic factors
date published: 2019
date modified: 2026-07-24T02:08:46Z
provider: University of Dundee
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Dundee