{"id":{"repo_id":"dundee","oai_identifier":"oai:discovery.dundee.ac.uk:studenttheses/15d5c38e-b000-4dcb-be35-49a46feb4664"},"canonical_url":"https://search.dev.ndltd.org/etd/dundee/oai:discovery.dundee.ac.uk:studenttheses/15d5c38e-b000-4dcb-be35-49a46feb4664","repository":{"repo_id":"dundee","name":"University of Dundee","base_url":"https://discovery.dundee.ac.uk/ws/oai"},"display":{"title":"The role of pax genes in vertebrate segmentation","abstract":"Pax genes are involved in a range of processes in the developing embryo. Pax3 and Pax7 in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the paraxial mesoderm. Here we examine the expression of Pax3 and Pax7 in the chicken presomitic mesoderm, and investigate their function using an in ovo electroporation transfection technique. We find that Pax3/7 drives precocious differentiation of PSM towards the myogenic lineage, as well as inducing a range of morphological changes in PSM tissue. These changes include alterations in the cytoskeleton, cell adhesion, and extracellular matrix formation.","abstract_html":"Pax genes are involved in a range of processes in the developing embryo. Pax3 and Pax7 in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the paraxial mesoderm. Here we examine the expression of Pax3 and Pax7 in the chicken presomitic mesoderm, and investigate their function using an in ovo electroporation transfection technique. We find that Pax3/7 drives precocious differentiation of PSM towards the myogenic lineage, as well as inducing a range of morphological changes in PSM tissue. These changes include alterations in the cytoskeleton, cell adhesion, and extracellular matrix formation.","abstract_has_math":false,"creators":["Wright, David"],"institution":"University of Dundee","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-24T02:07:39Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:discovery.dundee.ac.uk:studenttheses/15d5c38e-b000-4dcb-be35-49a46feb4664"],"render_values":[{"text":"oai:discovery.dundee.ac.uk:studenttheses/15d5c38e-b000-4dcb-be35-49a46feb4664","href":null,"code":true}]}]},"links":{"outbound_url":"https://discovery.dundee.ac.uk/en/studentTheses/15d5c38e-b000-4dcb-be35-49a46feb4664","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Wright, David"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2010"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Cell and Developmental Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Dundee"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://discovery.dundee.ac.uk/en/studentTheses/15d5c38e-b000-4dcb-be35-49a46feb4664"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:discovery.dundee.ac.uk:studenttheses/15d5c38e-b000-4dcb-be35-49a46feb4664","https://discovery.dundee.ac.uk/en/studentTheses/15d5c38e-b000-4dcb-be35-49a46feb4664"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://discovery.dundee.ac.uk/files/1193849/Wright_phd_2010.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Pax genes are involved in a range of processes in the developing embryo. Pax3 and Pax7 in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the paraxial mesoderm. Here we examine the expression of Pax3 and Pax7 in the chicken presomitic mesoderm, and investigate their function using an in ovo electroporation transfection technique. We find that Pax3/7 drives precocious differentiation of PSM towards the myogenic lineage, as well as inducing a range of morphological changes in PSM tissue. These changes include alterations in the cytoskeleton, cell adhesion, and extracellular matrix formation."]},{"key":"dc:title","label":"Title","values":["The role of pax genes in vertebrate segmentation"]}]}],"canonical_facts":{"dc:creator":["Wright, David"],"dc:date":["2010"],"dc:date.issued":["2010"],"dc:description.abstract":["Pax genes are involved in a range of processes in the developing embryo. Pax3 and Pax7 in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the paraxial mesoderm. Here we examine the expression of Pax3 and Pax7 in the chicken presomitic mesoderm, and investigate their function using an in ovo electroporation transfection technique. We find that Pax3/7 drives precocious differentiation of PSM towards the myogenic lineage, as well as inducing a range of morphological changes in PSM tissue. 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