{"id":{"repo_id":"drake","oai_identifier":"oai:escholarshare.drake.edu:2092/993"},"canonical_url":"https://search.dev.ndltd.org/etd/drake/oai:escholarshare.drake.edu:2092/993","repository":{"repo_id":"drake","name":"Drake University","base_url":"https://escholarshare.drake.edu/server/oai/request"},"display":{"title":"Effects of the Administration of 5-Hydroxydl-Tryptophan and 3,4-Dihydroxyphenylalanine on the Acquisition of a Conditioned Avoidance Response","abstract":"The administration of 3,4-dihydroxyphenylalanine (L-Dopa) has been shown to result in the facilitation of performance while the administration of 5-hydroxytryptophan (5-HTP) results in an impairment of performance and reported enhancement of acquisition. The purpose of the present study is to compare the effects of 5-HTP and L-Dopa on the acquisition of a single behavioral task. Each animal received a total of twenty daily trials in a shuttle box one hour after injection. All mice learned to avoid footshock both during each trial and the inter-trial interval. The results indicate that 5-HTP and L-Dopa do not facilitate the acquisition of a conditioned avoidance task. A significant number of inter-trial crossovers was obtained for the L-Dopa group for the 13 days of training and the 5-HTP group for the first 2 days. It was concluded that possible peripheral effects of L-Dopa interfered with acquisition. It was suggested that the effects of 5-HTP upon the visual system might have served to inhibit acquisition of a visual task. In view of the subject x treatment interaction, it would appear that the metabolites of 5-HTP and L-Dopa produced effects which varied within subjects as a function of the daily administration of precursors. The further analysis of effects of 5-HTP and L-Dopa on acquisition should include correlations between variations in regional concentrations and specific behaviors.","abstract_html":"The administration of 3,4-dihydroxyphenylalanine (L-Dopa) has been shown to result in the facilitation of performance while the administration of 5-hydroxytryptophan (5-HTP) results in an impairment of performance and reported enhancement of acquisition. The purpose of the present study is to compare the effects of 5-HTP and L-Dopa on the acquisition of a single behavioral task. Each animal received a total of twenty daily trials in a shuttle box one hour after injection. All mice learned to avoid footshock both during each trial and the inter-trial interval. The results indicate that 5-HTP and L-Dopa do not facilitate the acquisition of a conditioned avoidance task. A significant number of inter-trial crossovers was obtained for the L-Dopa group for the 13 days of training and the 5-HTP group for the first 2 days. It was concluded that possible peripheral effects of L-Dopa interfered with acquisition. It was suggested that the effects of 5-HTP upon the visual system might have served to inhibit acquisition of a visual task. In view of the subject x treatment interaction, it would appear that the metabolites of 5-HTP and L-Dopa produced effects which varied within subjects as a function of the daily administration of precursors. The further analysis of effects of 5-HTP and L-Dopa on acquisition should include correlations between variations in regional concentrations and specific behaviors.","abstract_has_math":false,"creators":["Percy, Hector"],"institution":"Drake University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1974,"date_issued":"1974-07","date_published":"1974-07","updated_at":"2026-07-27T19:18:43Z","subjects":["Dopa","Hydroxytryptophan","Conditioned response"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["1974 .P412"],"render_values":[{"text":"1974 .P412","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2092/993","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Percy, Hector"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2009-11-20T17:58:19Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2009-11-20T17:58:19Z"]},{"key":"dc:date.issued","label":"Date","values":["1974-07"]},{"key":"dc:publisher","label":"Institution","values":["Drake University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Dopa","Hydroxytryptophan","Conditioned response"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["1974 .P412"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2092/993"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["39, [3] leaves. Advisor: Kenneth Lloyd"]},{"key":"dc:description.abstract","label":"Abstract","values":["The administration of 3,4-dihydroxyphenylalanine (L-Dopa) has been shown to result in the facilitation of performance while the administration of 5-hydroxytryptophan (5-HTP) results in an impairment of performance and reported enhancement of acquisition. The purpose of the present study is to compare the effects of 5-HTP and L-Dopa on the acquisition of a single behavioral task. Each animal received a total of twenty daily trials in a shuttle box one hour after injection. All mice learned to avoid footshock both during each trial and the inter-trial interval. The results indicate that 5-HTP and L-Dopa do not facilitate the acquisition of a conditioned avoidance task. A significant number of inter-trial crossovers was obtained for the L-Dopa group for the 13 days of training and the 5-HTP group for the first 2 days. It was concluded that possible peripheral effects of L-Dopa interfered with acquisition. It was suggested that the effects of 5-HTP upon the visual system might have served to inhibit acquisition of a visual task. In view of the subject x treatment interaction, it would appear that the metabolites of 5-HTP and L-Dopa produced effects which varied within subjects as a function of the daily administration of precursors. The further analysis of effects of 5-HTP and L-Dopa on acquisition should include correlations between variations in regional concentrations and specific behaviors."]},{"key":"dc:title","label":"Title","values":["Effects of the Administration of 5-Hydroxydl-Tryptophan and 3,4-Dihydroxyphenylalanine on the Acquisition of a Conditioned Avoidance Response"]}]}],"canonical_facts":{"dc:creator":["Percy, Hector"],"dc:date.accessioned":["2009-11-20T17:58:19Z"],"dc:date.available":["2009-11-20T17:58:19Z"],"dc:date.issued":["1974-07"],"dc:description":["39, [3] leaves. Advisor: Kenneth Lloyd"],"dc:description.abstract":["The administration of 3,4-dihydroxyphenylalanine (L-Dopa) has been shown to result in the facilitation of performance while the administration of 5-hydroxytryptophan (5-HTP) results in an impairment of performance and reported enhancement of acquisition. The purpose of the present study is to compare the effects of 5-HTP and L-Dopa on the acquisition of a single behavioral task. Each animal received a total of twenty daily trials in a shuttle box one hour after injection. All mice learned to avoid footshock both during each trial and the inter-trial interval. The results indicate that 5-HTP and L-Dopa do not facilitate the acquisition of a conditioned avoidance task. A significant number of inter-trial crossovers was obtained for the L-Dopa group for the 13 days of training and the 5-HTP group for the first 2 days. It was concluded that possible peripheral effects of L-Dopa interfered with acquisition. It was suggested that the effects of 5-HTP upon the visual system might have served to inhibit acquisition of a visual task. In view of the subject x treatment interaction, it would appear that the metabolites of 5-HTP and L-Dopa produced effects which varied within subjects as a function of the daily administration of precursors. The further analysis of effects of 5-HTP and L-Dopa on acquisition should include correlations between variations in regional concentrations and specific behaviors."],"dc:identifier.other":["1974 .P412"],"dc:identifier.uri":["http://hdl.handle.net/2092/993"],"dc:language.iso":["en_US"],"dc:publisher":["Drake University"],"dc:subject":["Dopa","Hydroxytryptophan","Conditioned response"],"dc:title":["Effects of the Administration of 5-Hydroxydl-Tryptophan and 3,4-Dihydroxyphenylalanine on the Acquisition of a Conditioned Avoidance Response"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T19:18:43Z"}