{"id":{"repo_id":"drake","oai_identifier":"oai:escholarshare.drake.edu:2092/935"},"canonical_url":"https://search.dev.ndltd.org/etd/drake/oai:escholarshare.drake.edu:2092/935","repository":{"repo_id":"drake","name":"Drake University","base_url":"https://escholarshare.drake.edu/server/oai/request"},"display":{"title":"The Effects of Leucogenenol On Benzene Induced Bone Marrow Suppression In Rabbits","abstract":"The problem. These experiments were to determine the extent of leucocytosis and antibody production, stimulated by leucogenenol, in an animal whose white blood cells have been reduced by the action of benzene. Procedure. The white blood cell counts of rabbits were depressed to 1500 ± 500 cells per cubic millimeter by the action of benzene. At this time the animal, depending upon the grouping, was either given an injection of leucogenenol (2.0 or 0.2 ug) or allowed to recover on its own. Five groups of rabbits were maintained: Group 1, Control animals; Group 2, Benzene only; Group 3, Leucogenenol only; Group 4, Benzene and 0.2 ug of Leucogenenol; Group 5, Benzene and 2.0 ug of Leucogenenol. Findings. The variations of the rabbits blood profile did not provide significant results. The data seemed to indicate possibilities rather than firm conclusions. The differences between the control group and the experimental group were only slight and not clear or directional. Conclusion. The findings, although slight, indicate that leucogenenol does stimulate leucocytosis and antibody formation. Recommendations. With the use of an agent such as benzene, the effects of leucogenenol can be easily observed. The rabbit as the experimental animal should be changed to one more suitable.","abstract_html":"The problem. These experiments were to determine the extent of leucocytosis and antibody production, stimulated by leucogenenol, in an animal whose white blood cells have been reduced by the action of benzene. Procedure. The white blood cell counts of rabbits were depressed to 1500 ± 500 cells per cubic millimeter by the action of benzene. At this time the animal, depending upon the grouping, was either given an injection of leucogenenol (2.0 or 0.2 ug) or allowed to recover on its own. Five groups of rabbits were maintained: Group 1, Control animals; Group 2, Benzene only; Group 3, Leucogenenol only; Group 4, Benzene and 0.2 ug of Leucogenenol; Group 5, Benzene and 2.0 ug of Leucogenenol. Findings. The variations of the rabbits blood profile did not provide significant results. The data seemed to indicate possibilities rather than firm conclusions. The differences between the control group and the experimental group were only slight and not clear or directional. Conclusion. The findings, although slight, indicate that leucogenenol does stimulate leucocytosis and antibody formation. Recommendations. With the use of an agent such as benzene, the effects of leucogenenol can be easily observed. The rabbit as the experimental animal should be changed to one more suitable.","abstract_has_math":false,"creators":["Talluto, Joseph Francis"],"institution":"Drake University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1976,"date_issued":"1976-04","date_published":"1976-04","updated_at":"2026-07-27T19:19:15Z","subjects":["Leucocytosis","Rabbits as laboratory animals","Benzene","Bone marrow"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["1976 .T147"],"render_values":[{"text":"1976 .T147","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2092/935","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Talluto, Joseph Francis"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2009-06-17T19:27:43Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2009-06-17T19:27:43Z"]},{"key":"dc:date.issued","label":"Date","values":["1976-04"]},{"key":"dc:publisher","label":"Institution","values":["Drake University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Leucocytosis","Rabbits as laboratory animals","Benzene","Bone marrow"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["1976 .T147"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2092/935"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["36 leaves. Advisor: Dr. Rodney A. Rogers"]},{"key":"dc:description.abstract","label":"Abstract","values":["The problem. These experiments were to determine the extent of leucocytosis and antibody production, stimulated by leucogenenol, in an animal whose white blood cells have been reduced by the action of benzene. Procedure. The white blood cell counts of rabbits were depressed to 1500 ± 500 cells per cubic millimeter by the action of benzene. At this time the animal, depending upon the grouping, was either given an injection of leucogenenol (2.0 or 0.2 ug) or allowed to recover on its own. Five groups of rabbits were maintained: Group 1, Control animals; Group 2, Benzene only; Group 3, Leucogenenol only; Group 4, Benzene and 0.2 ug of Leucogenenol; Group 5, Benzene and 2.0 ug of Leucogenenol. Findings. The variations of the rabbits blood profile did not provide significant results. The data seemed to indicate possibilities rather than firm conclusions. The differences between the control group and the experimental group were only slight and not clear or directional. Conclusion. The findings, although slight, indicate that leucogenenol does stimulate leucocytosis and antibody formation. Recommendations. With the use of an agent such as benzene, the effects of leucogenenol can be easily observed. The rabbit as the experimental animal should be changed to one more suitable."]},{"key":"dc:title","label":"Title","values":["The Effects of Leucogenenol On Benzene Induced Bone Marrow Suppression In Rabbits"]}]}],"canonical_facts":{"dc:creator":["Talluto, Joseph Francis"],"dc:date.accessioned":["2009-06-17T19:27:43Z"],"dc:date.available":["2009-06-17T19:27:43Z"],"dc:date.issued":["1976-04"],"dc:description":["36 leaves. Advisor: Dr. Rodney A. Rogers"],"dc:description.abstract":["The problem. These experiments were to determine the extent of leucocytosis and antibody production, stimulated by leucogenenol, in an animal whose white blood cells have been reduced by the action of benzene. Procedure. The white blood cell counts of rabbits were depressed to 1500 ± 500 cells per cubic millimeter by the action of benzene. At this time the animal, depending upon the grouping, was either given an injection of leucogenenol (2.0 or 0.2 ug) or allowed to recover on its own. Five groups of rabbits were maintained: Group 1, Control animals; Group 2, Benzene only; Group 3, Leucogenenol only; Group 4, Benzene and 0.2 ug of Leucogenenol; Group 5, Benzene and 2.0 ug of Leucogenenol. Findings. The variations of the rabbits blood profile did not provide significant results. The data seemed to indicate possibilities rather than firm conclusions. The differences between the control group and the experimental group were only slight and not clear or directional. Conclusion. The findings, although slight, indicate that leucogenenol does stimulate leucocytosis and antibody formation. Recommendations. With the use of an agent such as benzene, the effects of leucogenenol can be easily observed. The rabbit as the experimental animal should be changed to one more suitable."],"dc:identifier.other":["1976 .T147"],"dc:identifier.uri":["http://hdl.handle.net/2092/935"],"dc:language.iso":["en_US"],"dc:publisher":["Drake University"],"dc:subject":["Leucocytosis","Rabbits as laboratory animals","Benzene","Bone marrow"],"dc:title":["The Effects of Leucogenenol On Benzene Induced Bone Marrow Suppression In Rabbits"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T19:19:15Z"}