{"id":{"repo_id":"drake","oai_identifier":"oai:escholarshare.drake.edu:2092/358"},"canonical_url":"https://search.dev.ndltd.org/etd/drake/oai:escholarshare.drake.edu:2092/358","repository":{"repo_id":"drake","name":"Drake University","base_url":"https://escholarshare.drake.edu/server/oai/request"},"display":{"title":"Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain","abstract":"MDMA (Ecstasy), a methylamphetamine derivative, has been found to produce severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance the rate of recovery of the neurons from the MDMA-induced effects. To assess this GM1 effect, MDMA (20 mglkg x 4 days), GM1 (40 mgkg), MDMA and GM1 or saline was injected (i.p.) into male rats. Behavioral activity was determined for 24 hours on day 5 or day 12 following the beginning of the injections. A general increase in activity on day 5 was noted for the MDMA group (consistent with a release of 5-HT and/or catecholamines) while the activity of the MDMA/GM 1 group was lower, at the level of the control. At day 12 the MDMA group's activity was decreased relative to the control (consistent with a 5-HT depletion) while the MDWGM 1 group's activity was at or above that of the control. Biochemical analysis of brain tissue obtained from the animals sacrificed on day 7 or 14 following the beginning of the injections demonstrated a profound depletion of 5-HT, dopamine and norepinephrine with administration of MDMA. The MDMA/GMl group also showed this depletion, though to a smaller degree, suggesting some attenuation of toxic effects.","abstract_html":"MDMA (Ecstasy), a methylamphetamine derivative, has been found to produce severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance the rate of recovery of the neurons from the MDMA-induced effects. To assess this GM1 effect, MDMA (20 mglkg x 4 days), GM1 (40 mgkg), MDMA and GM1 or saline was injected (i.p.) into male rats. Behavioral activity was determined for 24 hours on day 5 or day 12 following the beginning of the injections. A general increase in activity on day 5 was noted for the MDMA group (consistent with a release of 5-HT and/or catecholamines) while the activity of the MDMA/GM 1 group was lower, at the level of the control. At day 12 the MDMA group's activity was decreased relative to the control (consistent with a 5-HT depletion) while the MDWGM 1 group's activity was at or above that of the control. Biochemical analysis of brain tissue obtained from the animals sacrificed on day 7 or 14 following the beginning of the injections demonstrated a profound depletion of 5-HT, dopamine and norepinephrine with administration of MDMA. The MDMA/GMl group also showed this depletion, though to a smaller degree, suggesting some attenuation of toxic effects.","abstract_has_math":false,"creators":["Dunbar, Robert L."],"institution":"Drake University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1995,"date_issued":"1995-06","date_published":"1995-06","updated_at":"2026-07-27T19:19:36Z","subjects":["Ecstasy (Drug)","Drugs--Side effects","Neuropharmacolgy","Toxicological interactions","Gangliosides--Phyiological effect"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["1995 .D911"],"render_values":[{"text":"1995 .D911","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2092/358","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Dunbar, Robert L."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2006-05-04T14:00:22Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2006-05-04T14:00:22Z"]},{"key":"dc:date.issued","label":"Date","values":["1995-06"]},{"key":"dc:publisher","label":"Institution","values":["Drake University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Ecstasy (Drug)","Drugs--Side effects","Neuropharmacolgy","Toxicological interactions","Gangliosides--Phyiological effect"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["1995 .D911"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2092/358"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["v, 42 leaves. Advisor: Rodney Rogers."]},{"key":"dc:description.abstract","label":"Abstract","values":["MDMA (Ecstasy), a methylamphetamine derivative, has been found to produce severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance the rate of recovery of the neurons from the MDMA-induced effects. To assess this GM1 effect, MDMA (20 mglkg x 4 days), GM1 (40 mgkg), MDMA and GM1 or saline was injected (i.p.) into male rats. Behavioral activity was determined for 24 hours on day 5 or day 12 following the beginning of the injections. A general increase in activity on day 5 was noted for the MDMA group (consistent with a release of 5-HT and/or catecholamines) while the activity of the MDMA/GM 1 group was lower, at the level of the control. At day 12 the MDMA group's activity was decreased relative to the control (consistent with a 5-HT depletion) while the MDWGM 1 group's activity was at or above that of the control. Biochemical analysis of brain tissue obtained from the animals sacrificed on day 7 or 14 following the beginning of the injections demonstrated a profound depletion of 5-HT, dopamine and norepinephrine with administration of MDMA. The MDMA/GMl group also showed this depletion, though to a smaller degree, suggesting some attenuation of toxic effects."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain"]}]}],"canonical_facts":{"dc:creator":["Dunbar, Robert L."],"dc:date.accessioned":["2006-05-04T14:00:22Z"],"dc:date.available":["2006-05-04T14:00:22Z"],"dc:date.issued":["1995-06"],"dc:description":["v, 42 leaves. Advisor: Rodney Rogers."],"dc:description.abstract":["MDMA (Ecstasy), a methylamphetamine derivative, has been found to produce severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance the rate of recovery of the neurons from the MDMA-induced effects. To assess this GM1 effect, MDMA (20 mglkg x 4 days), GM1 (40 mgkg), MDMA and GM1 or saline was injected (i.p.) into male rats. Behavioral activity was determined for 24 hours on day 5 or day 12 following the beginning of the injections. A general increase in activity on day 5 was noted for the MDMA group (consistent with a release of 5-HT and/or catecholamines) while the activity of the MDMA/GM 1 group was lower, at the level of the control. At day 12 the MDMA group's activity was decreased relative to the control (consistent with a 5-HT depletion) while the MDWGM 1 group's activity was at or above that of the control. Biochemical analysis of brain tissue obtained from the animals sacrificed on day 7 or 14 following the beginning of the injections demonstrated a profound depletion of 5-HT, dopamine and norepinephrine with administration of MDMA. The MDMA/GMl group also showed this depletion, though to a smaller degree, suggesting some attenuation of toxic effects."],"dc:format.mimetype":["application/pdf"],"dc:identifier.other":["1995 .D911"],"dc:identifier.uri":["http://hdl.handle.net/2092/358"],"dc:language.iso":["en_US"],"dc:publisher":["Drake University"],"dc:subject":["Ecstasy (Drug)","Drugs--Side effects","Neuropharmacolgy","Toxicological interactions","Gangliosides--Phyiological effect"],"dc:title":["Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T19:19:36Z"}