{"id":{"repo_id":"drake","oai_identifier":"oai:escholarshare.drake.edu:2092/1094"},"canonical_url":"https://search.dev.ndltd.org/etd/drake/oai:escholarshare.drake.edu:2092/1094","repository":{"repo_id":"drake","name":"Drake University","base_url":"https://escholarshare.drake.edu/server/oai/request"},"display":{"title":"A Cytogenetic and Karyotypic Study of Eighty-Seven Patients Clinically Diagnosed as Having Down's Syndrome at Woodward State Hospital","abstract":"The problem. Eighty-seven patients clinically diagnosed as having Down's syndrome were studied by chromosome analysis at Woodward State Hospital, Woodward, Iowa, during June and July of 1972. Procedure. A cytogenetic analysis was made on chromosomes prepared from leucocytes cultured from peripheral blood. Ten cells were counted and karyotypes prepared for each patient. Findings. Among the eighty-seven patients, 54 males and 33 females, 60 (69%) were trisomic, 26 (29.9%) showed possible mosaicism and 1 (1.15%) carried a translocation. Three of the residents, including the patient with a translocation, were one of a set of twins. Conclusion. The frequency of Down's syndrome based on a Woodward population of 750 residents was 11.6%. This frequency is in agreement with a reported frequency of 11.2% individuals with Down's syndrome determined from a 1967 census of 23,211 people in institutions for the mentally retarded. The frequency of 60 trisomic Down syndrome patients (69%) was lower than the 93% figure found by most investigators. The observed frequency (1.15%) of translocation Down's syndrome is lower than reported frequencies of 3 to 4% for other institutions. A frequency of mosaic Down's syndrome in the Woodward population of 29.9% is considerably higher than the 1 to 2% reported elsewhere for similar populations. The observed cases of presumptive mosaicism may include cases of regular trisomy which wiil be resolved by more extensive cytogenetic analysis. Recommendations. A follow-up study to more completely characterize the mosaic Down's syndrome population is warranted to resolve the large observed deviation.","abstract_html":"The problem. Eighty-seven patients clinically diagnosed as having Down's syndrome were studied by chromosome analysis at Woodward State Hospital, Woodward, Iowa, during June and July of 1972. Procedure. A cytogenetic analysis was made on chromosomes prepared from leucocytes cultured from peripheral blood. Ten cells were counted and karyotypes prepared for each patient. Findings. Among the eighty-seven patients, 54 males and 33 females, 60 (69%) were trisomic, 26 (29.9%) showed possible mosaicism and 1 (1.15%) carried a translocation. Three of the residents, including the patient with a translocation, were one of a set of twins. Conclusion. The frequency of Down's syndrome based on a Woodward population of 750 residents was 11.6%. This frequency is in agreement with a reported frequency of 11.2% individuals with Down's syndrome determined from a 1967 census of 23,211 people in institutions for the mentally retarded. The frequency of 60 trisomic Down syndrome patients (69%) was lower than the 93% figure found by most investigators. The observed frequency (1.15%) of translocation Down's syndrome is lower than reported frequencies of 3 to 4% for other institutions. A frequency of mosaic Down's syndrome in the Woodward population of 29.9% is considerably higher than the 1 to 2% reported elsewhere for similar populations. The observed cases of presumptive mosaicism may include cases of regular trisomy which wiil be resolved by more extensive cytogenetic analysis. Recommendations. A follow-up study to more completely characterize the mosaic Down's syndrome population is warranted to resolve the large observed deviation.","abstract_has_math":false,"creators":["Pieper, William John"],"institution":"Drake University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1973,"date_issued":"1973-09","date_published":"1973-09","updated_at":"2026-07-27T19:17:50Z","subjects":["Down Syndrome","People with mental disabilities--Iowa--Woodward","Cytogenetics"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["1973 .P598"],"render_values":[{"text":"1973 .P598","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2092/1094","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Pieper, William John"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-02-18T14:49:15Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-02-18T14:49:15Z"]},{"key":"dc:date.issued","label":"Date","values":["1973-09"]},{"key":"dc:publisher","label":"Institution","values":["Drake University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Down Syndrome","People with mental disabilities--Iowa--Woodward","Cytogenetics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["1973 .P598"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2092/1094"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["38 leaves."]},{"key":"dc:description.abstract","label":"Abstract","values":["The problem. Eighty-seven patients clinically diagnosed as having Down's syndrome were studied by chromosome analysis at Woodward State Hospital, Woodward, Iowa, during June and July of 1972. Procedure. A cytogenetic analysis was made on chromosomes prepared from leucocytes cultured from peripheral blood. Ten cells were counted and karyotypes prepared for each patient. Findings. Among the eighty-seven patients, 54 males and 33 females, 60 (69%) were trisomic, 26 (29.9%) showed possible mosaicism and 1 (1.15%) carried a translocation. Three of the residents, including the patient with a translocation, were one of a set of twins. Conclusion. The frequency of Down's syndrome based on a Woodward population of 750 residents was 11.6%. This frequency is in agreement with a reported frequency of 11.2% individuals with Down's syndrome determined from a 1967 census of 23,211 people in institutions for the mentally retarded. The frequency of 60 trisomic Down syndrome patients (69%) was lower than the 93% figure found by most investigators. The observed frequency (1.15%) of translocation Down's syndrome is lower than reported frequencies of 3 to 4% for other institutions. A frequency of mosaic Down's syndrome in the Woodward population of 29.9% is considerably higher than the 1 to 2% reported elsewhere for similar populations. The observed cases of presumptive mosaicism may include cases of regular trisomy which wiil be resolved by more extensive cytogenetic analysis. Recommendations. A follow-up study to more completely characterize the mosaic Down's syndrome population is warranted to resolve the large observed deviation."]},{"key":"dc:title","label":"Title","values":["A Cytogenetic and Karyotypic Study of Eighty-Seven Patients Clinically Diagnosed as Having Down's Syndrome at Woodward State Hospital"]}]}],"canonical_facts":{"dc:creator":["Pieper, William John"],"dc:date.accessioned":["2010-02-18T14:49:15Z"],"dc:date.available":["2010-02-18T14:49:15Z"],"dc:date.issued":["1973-09"],"dc:description":["38 leaves."],"dc:description.abstract":["The problem. Eighty-seven patients clinically diagnosed as having Down's syndrome were studied by chromosome analysis at Woodward State Hospital, Woodward, Iowa, during June and July of 1972. Procedure. A cytogenetic analysis was made on chromosomes prepared from leucocytes cultured from peripheral blood. Ten cells were counted and karyotypes prepared for each patient. Findings. Among the eighty-seven patients, 54 males and 33 females, 60 (69%) were trisomic, 26 (29.9%) showed possible mosaicism and 1 (1.15%) carried a translocation. Three of the residents, including the patient with a translocation, were one of a set of twins. Conclusion. The frequency of Down's syndrome based on a Woodward population of 750 residents was 11.6%. This frequency is in agreement with a reported frequency of 11.2% individuals with Down's syndrome determined from a 1967 census of 23,211 people in institutions for the mentally retarded. The frequency of 60 trisomic Down syndrome patients (69%) was lower than the 93% figure found by most investigators. The observed frequency (1.15%) of translocation Down's syndrome is lower than reported frequencies of 3 to 4% for other institutions. A frequency of mosaic Down's syndrome in the Woodward population of 29.9% is considerably higher than the 1 to 2% reported elsewhere for similar populations. The observed cases of presumptive mosaicism may include cases of regular trisomy which wiil be resolved by more extensive cytogenetic analysis. Recommendations. A follow-up study to more completely characterize the mosaic Down's syndrome population is warranted to resolve the large observed deviation."],"dc:identifier.other":["1973 .P598"],"dc:identifier.uri":["http://hdl.handle.net/2092/1094"],"dc:language.iso":["en"],"dc:publisher":["Drake University"],"dc:subject":["Down Syndrome","People with mental disabilities--Iowa--Woodward","Cytogenetics"],"dc:title":["A Cytogenetic and Karyotypic Study of Eighty-Seven Patients Clinically Diagnosed as Having Down's Syndrome at Woodward State Hospital"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T19:17:50Z"}