Composición de la microbiota en pacientes pediátricos con déficit de hormona de crecimiento antes y después de recibir tratamiento con hormona de crecimiento
type: CreativeWork
description: The microbiota is defined as the community of micro-organisms that inhabit a specific environment. Generally, commensal microorganisms populate all epithelial surfaces of the body, the most numerous and complex being the gut. Alterations in the composition and functionality of the microbiota (dysbiosis) have been associated with various pathologies. Among the different functions of the microbiota, its role in growth is particularly important. Indeed, several studies have shown that germ-free mice lacking gut microbiota have reduced levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor transporter protein-3 (IGFBP-3) and poor growth, with decreased linear growth and body weight, suggesting that mammals require the gut microbiota to ensure optimal growth. In this regard, studies in preclinical animal models have shown that physiological levels of growth hormone (GH) maintain gut integrity and improve digestive function. This effect of GH occurs synergistically with IGF-1, as observed in bone growth, metabolic and intestinal homeostasis, suggesting some association between the GH-IGF-1 axis and the gut microbiota. GH deficiency in children has a prevalence of 1:3,480 children, and can occur in isolation or associated to other pituitary deficits. Clinically it is characterised by harmonic and postnatal hypogrowth. They have a decreased response to stimulation tests and reduced levels of IGF-1 and IGFBP-3. The indicated treatment is recombinant human GH. Therefore, and given the analytical characteristics of these patients, with decreased GH and IGF-1 levels, the aim of the present study was to investigate whether these alterations were associated with changes in intestinal physiology/integrity as well as in the intestinal microbiota composition. To achieve this objective, a case-control study was performed in 21 patients with GH deficiency prior to baseline and after 6 months of GH treatment and in 20 healthy controls. Anthropometric data, analyt…
abstract: The microbiota is defined as the community of micro-organisms that inhabit a specific environment. Generally, commensal microorganisms populate all epithelial surfaces of the body, the most numerous and complex being the gut. Alterations in the composition and functionality of the microbiota (dysbiosis) have been associated with various pathologies. Among the different functions of the microbiota, its role in growth is particularly important. Indeed, several studies have shown that germ-free mice lacking gut microbiota have reduced levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor transporter protein-3 (IGFBP-3) and poor growth, with decreased linear growth and body weight, suggesting that mammals require the gut microbiota to ensure optimal growth. In this regard, studies in preclinical animal models have shown that physiological levels of growth hormone (GH) maintain gut integrity and improve digestive function. This effect of GH occurs synergistically with IGF-1, as observed in bone growth, metabolic and intestinal homeostasis, suggesting some association between the GH-IGF-1 axis and the gut microbiota. GH deficiency in children has a prevalence of 1:3,480 children, and can occur in isolation or associated to other pituitary deficits. Clinically it is characterised by harmonic and postnatal hypogrowth. They have a decreased response to stimulation tests and reduced levels of IGF-1 and IGFBP-3. The indicated treatment is recombinant human GH. Therefore, and given the analytical characteristics of these patients, with decreased GH and IGF-1 levels, the aim of the present study was to investigate whether these alterations were associated with changes in intestinal physiology/integrity as well as in the intestinal microbiota composition. To achieve this objective, a case-control study was performed in 21 patients with GH deficiency prior to baseline and after 6 months of GH treatment and in 20 healthy controls. Anthropometric data, analyt…
author: García Navas, Patricia
language: spa
date published: 2025
date modified: 2026-07-24T06:27:07Z
provider: Dialnet
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Universidad de La Rioja (España)