{"id":{"repo_id":"dialnet","oai_identifier":"oai:dialnet.unirioja.es:TES0000023174"},"canonical_url":"https://search.dev.ndltd.org/etd/dialnet/oai:dialnet.unirioja.es:TES0000023174","repository":{"repo_id":"dialnet","name":"Dialnet","base_url":"https://dialnet.unirioja.es/oaites/OAIHandler"},"display":{"title":"MicroRNAs en tejido de cordón umbilical y su relación con el peso al nacimiento","abstract":"Intrauterine growth is a multifactorial process resulting from the interaction between the mother, placenta, fetus, and environmental factors. Birth weight is a key indicator of perinatal health, associated with both short- and long-term complications. In this context, microRNAs (miRNAs), essential epigenetic regulators of gene expression at the post-transcriptional level, may play a crucial role in birth weight alterations. The main objective of this study was to analyze the relationship between miRNA expression in umbilical cord tissue and birth weight. The study included 68 newborns classified into three groups: small for gestational age (SGA, n=10), large for gestational age (LGA, n=28), and controls with appropriate weight for gestational age (AGA, n=30). Umbilical cord tissue samples were collected immediately after delivery, frozen, and subsequently analyzed through massive sequencing and bioinformatics. The analysis identified significant differences in the expression of 41 miRNAs across the groups. SGA newborns showed overexpression of miR-9-3p and miR-324-3p and underexpression of miR-1307-3p compared to AGA controls. In the LGA group, decreased expression of miR-99b-3p, miR-101-3p, miR-125a-3p, among others, and increased expression of miR-455-3p and miR-574-3p were observed. Direct comparison between SGA and LGA groups revealed dysregulation of miRNAs such as miR-324-3p, miR-6750-5p, miR-3919, and miR-5009-3p. These miRNAs are associated with metabolic pathways involved in insulin resistance and diabetes mellitus. In conclusion, this study demonstrates that differential miRNA expression in umbilical cord tissue is linked to birth weight. The findings suggest that epigenetic alterations from the neonatal period may predispose individuals to the development of chronic metabolic diseases later in life.","abstract_html":"Intrauterine growth is a multifactorial process resulting from the interaction between the mother, placenta, fetus, and environmental factors. Birth weight is a key indicator of perinatal health, associated with both short- and long-term complications. In this context, microRNAs (miRNAs), essential epigenetic regulators of gene expression at the post-transcriptional level, may play a crucial role in birth weight alterations. The main objective of this study was to analyze the relationship between miRNA expression in umbilical cord tissue and birth weight. The study included 68 newborns classified into three groups: small for gestational age (SGA, n=10), large for gestational age (LGA, n=28), and controls with appropriate weight for gestational age (AGA, n=30). Umbilical cord tissue samples were collected immediately after delivery, frozen, and subsequently analyzed through massive sequencing and bioinformatics. The analysis identified significant differences in the expression of 41 miRNAs across the groups. SGA newborns showed overexpression of miR-9-3p and miR-324-3p and underexpression of miR-1307-3p compared to AGA controls. In the LGA group, decreased expression of miR-99b-3p, miR-101-3p, miR-125a-3p, among others, and increased expression of miR-455-3p and miR-574-3p were observed. Direct comparison between SGA and LGA groups revealed dysregulation of miRNAs such as miR-324-3p, miR-6750-5p, miR-3919, and miR-5009-3p. These miRNAs are associated with metabolic pathways involved in insulin resistance and diabetes mellitus. In conclusion, this study demonstrates that differential miRNA expression in umbilical cord tissue is linked to birth weight. The findings suggest that epigenetic alterations from the neonatal period may predispose individuals to the development of chronic metabolic diseases later in life.","abstract_has_math":false,"creators":["García Muro, Cristina"],"institution":"Universidad de La Rioja (España)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Ruiz del Prado, Mª Yolanda (Universidad de La Rioja)","Domínguez Garrido, Elena (Universidad de La Rioja)"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025","date_published":"2025","updated_at":"2026-07-24T06:27:07Z","subjects":[],"languages":["spa"],"rights":["LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://dialnet.unirioja.es/servlet/oaites?codigo=370082","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Ruiz del Prado, Mª Yolanda (Universidad de La Rioja)","Domínguez Garrido, Elena (Universidad de La Rioja)"]},{"key":"dc:creator","label":"Author","values":["García Muro, Cristina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025"]},{"key":"dc:publisher","label":"Institution","values":["Universidad de La Rioja (España)"]},{"key":"dc:type","label":"Dc Type","values":["text (thesis)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["spa"]},{"key":"dc:rights","label":"Dc Rights","values":["LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://dialnet.unirioja.es/servlet/oaites?codigo=370082"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Intrauterine growth is a multifactorial process resulting from the interaction between the mother, placenta, fetus, and environmental factors. Birth weight is a key indicator of perinatal health, associated with both short- and long-term complications. In this context, microRNAs (miRNAs), essential epigenetic regulators of gene expression at the post-transcriptional level, may play a crucial role in birth weight alterations. The main objective of this study was to analyze the relationship between miRNA expression in umbilical cord tissue and birth weight. The study included 68 newborns classified into three groups: small for gestational age (SGA, n=10), large for gestational age (LGA, n=28), and controls with appropriate weight for gestational age (AGA, n=30). Umbilical cord tissue samples were collected immediately after delivery, frozen, and subsequently analyzed through massive sequencing and bioinformatics. The analysis identified significant differences in the expression of 41 miRNAs across the groups. SGA newborns showed overexpression of miR-9-3p and miR-324-3p and underexpression of miR-1307-3p compared to AGA controls. In the LGA group, decreased expression of miR-99b-3p, miR-101-3p, miR-125a-3p, among others, and increased expression of miR-455-3p and miR-574-3p were observed. Direct comparison between SGA and LGA groups revealed dysregulation of miRNAs such as miR-324-3p, miR-6750-5p, miR-3919, and miR-5009-3p. These miRNAs are associated with metabolic pathways involved in insulin resistance and diabetes mellitus. In conclusion, this study demonstrates that differential miRNA expression in umbilical cord tissue is linked to birth weight. The findings suggest that epigenetic alterations from the neonatal period may predispose individuals to the development of chronic metabolic diseases later in life.","El crecimiento intrauterino es un proceso multifactorial que depende de la interacción entre la madre, la placenta, el feto y factores ambientales. El peso al nacimiento es un indicador clave de la salud perinatal, asociado con complicaciones a corto y largo plazo. En este contexto, los microRNAs (miRNAs), componentes epigenéticos esenciales en la regulación génica postranscripcional, podrían desempeñar un papel relevante en las alteraciones del peso al nacimiento. El objetivo principal de este estudio fue analizar la relación entre la expresión de miRNAs en tejido de cordón umbilical y el peso al nacimiento. Se incluyeron 68 recién nacidos clasificados en tres grupos: pequeños para la edad gestacional (PEG, n=10), grandes para la edad gestacional (GEG, n=28) y controles con peso adecuado para la edad gestacional (AEG, n=30). Las muestras de tejido de cordón umbilical se recogieron tras el parto, se almacenaron congeladas y fueron analizadas mediante secuenciación masiva y bioinformática. El análisis identificó diferencias significativas en 41 miRNAs entre los grupos. Los neonatos PEG mostraron sobreexpresión de miR-9-3p y miR-324-3p e infraexpresión de miR-1307-3p en comparación con los controles AEG. En los GEG, se encontró una disminución de miR-99b-3p, miR-101-3p, miR-125a-3p, entre otros, y un aumento de miR-455-3p y miR-574-3p. La comparación directa entre PEG y GEG evidenció desregulación de miRNAs como miR-324-3p, miR-6750-5p, miR-3919 y miR-5009-3p. Estos miRNAs están asociados con rutas metabólicas implicadas en la resistencia a la insulina y la diabetes mellitus. En conclusión, este trabajo muestra que la expresión diferencial de miRNAs en el tejido de cordón umbilical está vinculada al peso al nacimiento. Los hallazgos sugieren que alteraciones epigenéticas desde el periodo neonatal podrían predisponer al desarrollo de enfermedades metabólicas crónicas en la vida adulta."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["MicroRNAs en tejido de cordón umbilical y su relación con el peso al nacimiento"]}]}],"canonical_facts":{"dc:contributor":["Ruiz del Prado, Mª Yolanda (Universidad de La Rioja)","Domínguez Garrido, Elena (Universidad de La Rioja)"],"dc:creator":["García Muro, Cristina"],"dc:date":["2025"],"dc:description":["Intrauterine growth is a multifactorial process resulting from the interaction between the mother, placenta, fetus, and environmental factors. Birth weight is a key indicator of perinatal health, associated with both short- and long-term complications. In this context, microRNAs (miRNAs), essential epigenetic regulators of gene expression at the post-transcriptional level, may play a crucial role in birth weight alterations. The main objective of this study was to analyze the relationship between miRNA expression in umbilical cord tissue and birth weight. The study included 68 newborns classified into three groups: small for gestational age (SGA, n=10), large for gestational age (LGA, n=28), and controls with appropriate weight for gestational age (AGA, n=30). Umbilical cord tissue samples were collected immediately after delivery, frozen, and subsequently analyzed through massive sequencing and bioinformatics. The analysis identified significant differences in the expression of 41 miRNAs across the groups. SGA newborns showed overexpression of miR-9-3p and miR-324-3p and underexpression of miR-1307-3p compared to AGA controls. In the LGA group, decreased expression of miR-99b-3p, miR-101-3p, miR-125a-3p, among others, and increased expression of miR-455-3p and miR-574-3p were observed. Direct comparison between SGA and LGA groups revealed dysregulation of miRNAs such as miR-324-3p, miR-6750-5p, miR-3919, and miR-5009-3p. These miRNAs are associated with metabolic pathways involved in insulin resistance and diabetes mellitus. In conclusion, this study demonstrates that differential miRNA expression in umbilical cord tissue is linked to birth weight. The findings suggest that epigenetic alterations from the neonatal period may predispose individuals to the development of chronic metabolic diseases later in life.","El crecimiento intrauterino es un proceso multifactorial que depende de la interacción entre la madre, la placenta, el feto y factores ambientales. El peso al nacimiento es un indicador clave de la salud perinatal, asociado con complicaciones a corto y largo plazo. En este contexto, los microRNAs (miRNAs), componentes epigenéticos esenciales en la regulación génica postranscripcional, podrían desempeñar un papel relevante en las alteraciones del peso al nacimiento. El objetivo principal de este estudio fue analizar la relación entre la expresión de miRNAs en tejido de cordón umbilical y el peso al nacimiento. Se incluyeron 68 recién nacidos clasificados en tres grupos: pequeños para la edad gestacional (PEG, n=10), grandes para la edad gestacional (GEG, n=28) y controles con peso adecuado para la edad gestacional (AEG, n=30). Las muestras de tejido de cordón umbilical se recogieron tras el parto, se almacenaron congeladas y fueron analizadas mediante secuenciación masiva y bioinformática. El análisis identificó diferencias significativas en 41 miRNAs entre los grupos. Los neonatos PEG mostraron sobreexpresión de miR-9-3p y miR-324-3p e infraexpresión de miR-1307-3p en comparación con los controles AEG. En los GEG, se encontró una disminución de miR-99b-3p, miR-101-3p, miR-125a-3p, entre otros, y un aumento de miR-455-3p y miR-574-3p. La comparación directa entre PEG y GEG evidenció desregulación de miRNAs como miR-324-3p, miR-6750-5p, miR-3919 y miR-5009-3p. Estos miRNAs están asociados con rutas metabólicas implicadas en la resistencia a la insulina y la diabetes mellitus. En conclusión, este trabajo muestra que la expresión diferencial de miRNAs en el tejido de cordón umbilical está vinculada al peso al nacimiento. Los hallazgos sugieren que alteraciones epigenéticas desde el periodo neonatal podrían predisponer al desarrollo de enfermedades metabólicas crónicas en la vida adulta."],"dc:format":["application/pdf"],"dc:identifier":["https://dialnet.unirioja.es/servlet/oaites?codigo=370082"],"dc:language":["spa"],"dc:publisher":["Universidad de La Rioja (España)"],"dc:rights":["LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI"],"dc:title":["MicroRNAs en tejido de cordón umbilical y su relación con el peso al nacimiento"],"dc:type":["text (thesis)"]},"updated_at":"2026-07-24T06:27:07Z"}