Atividade antiulcerogênica de Alcaloides Pirrolizidínicos obtidos a partir do Extrato Etanólico de Senecio brasiliensis: perspectivas de uma nova terapêutica preventiva e curativa das úlceras gástricas e duodenais

Senecio brasiliensis is a native plant from South América and is found mainly in Brazil. Popularly Senecio is knowed as Margaridinha, Flor-das-Almas, Tasneirinha and is very utilized by folk medicine to the treatment of gastrointestinal diseases. Phytochemical analysis showed the presence of Pyrrolizidine Alkaloids (Pas) from Senecio brasiliensis. This study have a objective the obtained of PAs extract and evaluated the antiulcerogenic activity of the PAs on Standard rodent models. Furthermore this study also evaluated the probable pharmacological mechanism(s) of the PAs. The results showed the antiulcerogenic activity on gastric and duodenal induced ulcerogenic lesions. The pharmacological mechanisms showed that PAs can be a quantitative and probable therapy alternative in the future. News assays are necessary to determinate the efficacy and safety of this drug.

Grantor dc:publisher

Universidade Estadual de Campinas (Brasil)

Year dc:date

2003

Author dc:creator

• Toma, Walber

Contributors dc:contributor

• Regina Monteiro Souza Brito, Alba (Universidade Estadual de Campinas)

• Plantas medicinales
• Senecio Braziliensis
• Senecios Braziliensis
• preventive therapy

Statement dc:rights

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Language dc:language

por

Repository record dc:identifier

https://dialnet.unirioja.es/servlet/oaites?codigo=18684

OAI identifier oai:identifier

oai:dialnet.unirioja.es:TES0000001336