Computational Methodology for Generating Patient-Specific Soft Tissue Representations

<p>This dissertation focused on modeling specimen-specific soft tissue structures in the context of joint replacement surgery. The research addressed four key aspects. The first study involved developing a workflow for creating finite element models of the hip capsule to replicate its torque-rotational response. Experimental data from ten cadaveric hips were used to calibrate the models, resulting in improved accuracy and relevance for surgical planning and implant design. The second study tackled the challenge of expediting the calibration of mechanical properties of the hip capsule to match patient-specific laxities. A statistical shape function model was proposed to generate patient-specific finite element models, demonstrating potential for instant modeling and potential use in improving outcomes in hip arthroplasty. The third study involved developing a computational model of an experimental knee simulator for simultaneous evaluation of tibiofemoral and patellofemoral mechanics. The model's predictions were verified against experimental measurements, providing a reliable computational tool for further studies. The fourth study investigated the influence of soft tissue balance and implant congruency on knee stability during daily activities. Finite element models were calibrated based on experimental data, perturbed for varying soft-tissue imbalance levels, evaluated for stability during the activities of daily living, thereby highlighting the impact of implant design on stability. The dissertation's findings contribute to the knowledge of surgical planning, implant design, and potentially enhancing outcomes in joint replacement surgeries.</p>

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Year

2023

Author dc:creator

• Anantha Krishnan, Ahilan

Contributors dc:contributor

• Chadd Clary
• Daniel Linseman
• Paul Rullkoetter
• Peter Laz

• Biomechanics
• Patient specific
• Soft tissue
• Surgical planning
• Total hip replacement
• Total knee replacement
• Biomechanical Engineering
• Biomechanics and Biotransport
• Biomedical Engineering and Bioengineering
• Engineering
• Mechanical Engineering

Statement dc:rights

• <p>Copyright is held by the author. User is responsible for all copyright compliance.</p>

Language dc:language

English (eng)

Repository record dc:identifier

https://digitalcommons.du.edu/etd/2341

OAI identifier oai:identifier

oai:digitalcommons.du.edu:etd-3327