Transcatheter mitral valve replacement (TMVR) is being developed to become a substitute therapy for surgery in prohibitive or high surgical risk patients to treat severe mitral regurgitation. A limited number of TMVR systems are under clinical evaluation. However, transcatheter mitral valve (TMV) long-term durability and hemodynamic performance is not known. TMV durability and hemodynamics must match with that of surgical bioprostheses for potential commercialization of TMVR. Experimental and computational approaches were used to find the leaflets’ three-dimensional anisotropic mechanical properties in a transcatheter Edwards SAPIEN 3 valve and a surgical Carpentier-Edwards PERIMOUNT Magna mitral valve and finite element (FE) simulations were conducted to obtain the stress distribution on both valves. Moreover, to visualize the flow field within the left heart, steady-state computational fluid dynamics (CFD) simulations were run. The FE simulations demonstrated that in a cardiac cycle, at peak systole, the highest stress value in the two bioprostheses was 4.75 and 16 MPa for the surgical and transcatheter heart valve, respectively. After studying the leaflet stress distributions and flow field, long-term durability may potentially be different between the two models. The results of CFD simulations could potentially show that TMVs with supra-annular positioning have a higher risk of leaflet thrombosis as opposed to the intra-annular position.
","abstract_html":"<p>Transcatheter mitral valve replacement (TMVR) is being developed to become a substitute therapy for surgery in prohibitive or high surgical risk patients to treat severe mitral regurgitation. A limited number of TMVR systems are under clinical evaluation. However, transcatheter mitral valve (TMV) long-term durability and hemodynamic performance is not known. TMV durability and hemodynamics must match with that of surgical bioprostheses for potential commercialization of TMVR. Experimental and computational approaches were used to find the leaflets’ three-dimensional anisotropic mechanical properties in a transcatheter Edwards SAPIEN 3 valve and a surgical Carpentier-Edwards PERIMOUNT Magna mitral valve and finite element (FE) simulations were conducted to obtain the stress distribution on both valves. Moreover, to visualize the flow field within the left heart, steady-state computational fluid dynamics (CFD) simulations were run. The FE simulations demonstrated that in a cardiac cycle, at peak systole, the highest stress value in the two bioprostheses was 4.75 and 16 MPa for the surgical and transcatheter heart valve, respectively. After studying the leaflet stress distributions and flow field, long-term durability may potentially be different between the two models. The results of CFD simulations could potentially show that TMVs with supra-annular positioning have a higher risk of leaflet thrombosis as opposed to the intra-annular position.</p>","abstract_has_math":false,"creators":["Ravaghi, Saba"],"institution":null,"degree_name":"M. S.","degree_level":"Masters Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Ali N. Azadani","Chadd W. Clary","James Fogleman"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-01-01T08:00:00Z","date_published":"2020-01-01T08:00:00Z","updated_at":"2026-07-24T02:02:03Z","subjects":["Durability","Mitral valve","Transcatheter","Biomechanics and Biotransport","Biomedical Devices and Instrumentation","Biomedical Engineering and Bioengineering"],"languages":["en"],"rights":["Copyright is held by the author. User is responsible for all copyright compliance.
"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.du.edu/etd/1831","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Ali N. Azadani","Chadd W. Clary","James Fogleman"]},{"key":"dc:creator","label":"Author","values":["Ravaghi, Saba"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2021-03-02T08:00:00Z"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M. S."]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Durability","Mitral valve","Transcatheter","Biomechanics and Biotransport","Biomedical Devices and Instrumentation","Biomedical Engineering and Bioengineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright is held by the author. User is responsible for all copyright compliance.
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"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Transcatheter Mitral Valve Replacement: Structural and Hemodynamic Analysis"]}]}],"canonical_facts":{"dc:contributor":["Ali N. Azadani","Chadd W. Clary","James Fogleman"],"dc:creator":["Ravaghi, Saba"],"dc:date.available":["2021-03-02T08:00:00Z"],"dc:description.abstract":["Transcatheter mitral valve replacement (TMVR) is being developed to become a substitute therapy for surgery in prohibitive or high surgical risk patients to treat severe mitral regurgitation. A limited number of TMVR systems are under clinical evaluation. However, transcatheter mitral valve (TMV) long-term durability and hemodynamic performance is not known. TMV durability and hemodynamics must match with that of surgical bioprostheses for potential commercialization of TMVR. Experimental and computational approaches were used to find the leaflets’ three-dimensional anisotropic mechanical properties in a transcatheter Edwards SAPIEN 3 valve and a surgical Carpentier-Edwards PERIMOUNT Magna mitral valve and finite element (FE) simulations were conducted to obtain the stress distribution on both valves. Moreover, to visualize the flow field within the left heart, steady-state computational fluid dynamics (CFD) simulations were run. The FE simulations demonstrated that in a cardiac cycle, at peak systole, the highest stress value in the two bioprostheses was 4.75 and 16 MPa for the surgical and transcatheter heart valve, respectively. After studying the leaflet stress distributions and flow field, long-term durability may potentially be different between the two models. The results of CFD simulations could potentially show that TMVs with supra-annular positioning have a higher risk of leaflet thrombosis as opposed to the intra-annular position.
"],"dc:format":["application/pdf"],"dc:identifier":["https://digitalcommons.du.edu/etd/1831"],"dc:language":["en"],"dc:rights":["Copyright is held by the author. User is responsible for all copyright compliance.
"],"dc:subject":["Durability","Mitral valve","Transcatheter","Biomechanics and Biotransport","Biomedical Devices and Instrumentation","Biomedical Engineering and Bioengineering"],"dc:title":["Transcatheter Mitral Valve Replacement: Structural and Hemodynamic Analysis"],"thesis:degree_level":["Masters Thesis"],"thesis:degree_name":["M. S."]},"updated_at":"2026-07-24T02:02:03Z"}