Quality of Life (QOL) in Parkinson's disease (PD) patients after Deep Brain Stimulation (DBS) neurosurgery generally improves between 3 to 24 months post-operatively. However, QOL beyond 2 year follow-up is generally unknown. This study examined the QOL in 16 advanced PD patients who received DBS at an average of 7.5 year follow-up with the Parkinson's Disease Questionnaire (PDQ-39). Participants had an average Disease Duration of 20.57 years (SD 5.7) and a mean Age of 63.50 (SD 8.05). Linear regression analyses suggested a constellation of changes involving Time, Age, and Disease Duration. As Time progressed since DBS intervention, the PDQ-39 Cognitions subscale worsened (p < .05). Increasing Age was associated with improvement in Stigma-related QOL (p < .01). Rising Disease Duration correlated with improvements in three PDQ-39 subscales: (a) Stigma (p < .01), (b) Emotional Well-Being (p < .01), and (c) Social Support (p < .05). Findings suggested the need to further explore the domains and dimensions of QOL change post-DBS intervention, as well as other methods to measure the depth and breadth of QOL in DBS recipients.
","abstract_html":"<p>Quality of Life (QOL) in Parkinson's disease (PD) patients after Deep Brain Stimulation (DBS) neurosurgery generally improves between 3 to 24 months post-operatively. However, QOL beyond 2 year follow-up is generally unknown. This study examined the QOL in 16 advanced PD patients who received DBS at an average of 7.5 year follow-up with the Parkinson's Disease Questionnaire (PDQ-39). Participants had an average Disease Duration of 20.57 years (SD 5.7) and a mean Age of 63.50 (SD 8.05). Linear regression analyses suggested a constellation of changes involving Time, Age, and Disease Duration. As Time progressed since DBS intervention, the PDQ-39 Cognitions subscale worsened (<em>p</em> < .05). Increasing Age was associated with improvement in Stigma-related QOL (<em>p</em> < .01). Rising Disease Duration correlated with improvements in three PDQ-39 subscales: (a) Stigma (<em>p</em> < .01), (b) Emotional Well-Being (<em>p</em> < .01), and (c) Social Support (<em>p</em> < .05). Findings suggested the need to further explore the domains and dimensions of QOL change post-DBS intervention, as well as other methods to measure the depth and breadth of QOL in DBS recipients.</p>","abstract_has_math":false,"creators":["Chiang, Karl S."],"institution":null,"degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Cynthia A. McRae, Ph.D.","Kathy Green","Brian D. Hoyt","Roger E. Salters"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009-08-01T07:00:00Z","date_published":"2009-08-01T07:00:00Z","updated_at":"2026-07-24T02:02:03Z","subjects":["Behavioral medicine","Deep brain stimulation","Movement disorders","Parkinson Disease","Psychology","Quality of life","Clinical Psychology","Social and Behavioral Sciences"],"languages":["en"],"rights":["Copyright is held by the author. User is responsible for all copyright compliance.
"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.du.edu/etd/124","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Cynthia A. McRae, Ph.D.","Kathy Green","Brian D. Hoyt","Roger E. Salters"]},{"key":"dc:creator","label":"Author","values":["Chiang, Karl S."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2001-01-01T08:00:00Z"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Behavioral medicine","Deep brain stimulation","Movement disorders","Parkinson Disease","Psychology","Quality of life","Clinical Psychology","Social and Behavioral Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright is held by the author. User is responsible for all copyright compliance.
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"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Trajectory of Quality of Life in Advanced Parkinson's Patients Receiving Bilateral Subthalamic Nucleus Deep Brain Stimulation"]}]}],"canonical_facts":{"dc:contributor":["Cynthia A. McRae, Ph.D.","Kathy Green","Brian D. Hoyt","Roger E. Salters"],"dc:creator":["Chiang, Karl S."],"dc:date.available":["2001-01-01T08:00:00Z"],"dc:description.abstract":["Quality of Life (QOL) in Parkinson's disease (PD) patients after Deep Brain Stimulation (DBS) neurosurgery generally improves between 3 to 24 months post-operatively. However, QOL beyond 2 year follow-up is generally unknown. This study examined the QOL in 16 advanced PD patients who received DBS at an average of 7.5 year follow-up with the Parkinson's Disease Questionnaire (PDQ-39). Participants had an average Disease Duration of 20.57 years (SD 5.7) and a mean Age of 63.50 (SD 8.05). Linear regression analyses suggested a constellation of changes involving Time, Age, and Disease Duration. As Time progressed since DBS intervention, the PDQ-39 Cognitions subscale worsened (p < .05). Increasing Age was associated with improvement in Stigma-related QOL (p < .01). Rising Disease Duration correlated with improvements in three PDQ-39 subscales: (a) Stigma (p < .01), (b) Emotional Well-Being (p < .01), and (c) Social Support (p < .05). Findings suggested the need to further explore the domains and dimensions of QOL change post-DBS intervention, as well as other methods to measure the depth and breadth of QOL in DBS recipients.
"],"dc:format":["application/pdf"],"dc:identifier":["https://digitalcommons.du.edu/etd/124"],"dc:language":["en"],"dc:rights":["Copyright is held by the author. User is responsible for all copyright compliance.
"],"dc:subject":["Behavioral medicine","Deep brain stimulation","Movement disorders","Parkinson Disease","Psychology","Quality of life","Clinical Psychology","Social and Behavioral Sciences"],"dc:title":["Trajectory of Quality of Life in Advanced Parkinson's Patients Receiving Bilateral Subthalamic Nucleus Deep Brain Stimulation"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."]},"updated_at":"2026-07-24T02:02:03Z"}