Endocrine Effects of Cancer Chemotherapy

This thesis explores the pharmacological effects of cancer chemotherapy on endocrine organs, emphasizing both therapeutic advantages and adverse effects. It categorizes chemotherapeutic agents based on their mechanisms of action and their impact on endocrine function, highlighting both intended hormonal modulation and unintended endocrine toxicities. The thesis adopts both a pharmacological and organ-specific approach, detailing how different drug classes—such as alkylating agents, antimetabolites, antitumor antibiotics, targeted therapies, and immune checkpoint inhibitors—affect the endocrine system. It examines chemotherapy-induced dysfunctions in key endocrine glands, including the hypothalamus-pituitary axis, thyroid, adrenal glands, gonads, and pancreas. Special attention is given to long-term endocrine complications in cancer survivors, particularly in the context of emerging therapies such as immune checkpoint inhibitors. Ultimately, the thesis underscores the importance of early detection, individualized management, and continued research to mitigate endocrine-related toxicities while optimizing cancer treatment outcomes.

Department dc:contributor.department

DE--Általános Orvostudományi Kar

Author dc:creator

• Yang, Du Hyuk

Advisor dc:contributor.advisor

• Megyeri, Attila

• Chemotherapy
• Immune checkpoint inhibitors
• Endocrine

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/2437/389175

OAI identifier oai:identifier

oai:dea.lib.unideb.hu:2437/389175