{"id":{"repo_id":"debrecen","oai_identifier":"oai:dea.lib.unideb.hu:2437/369064"},"canonical_url":"https://search.dev.ndltd.org/etd/debrecen/oai:dea.lib.unideb.hu:2437/369064","repository":{"repo_id":"debrecen","name":"University of Debrecen","base_url":"https://dea.lib.unideb.hu/server/oai/request"},"display":{"title":"Hv1 novel peptide inhibitor extracted from tarantula venom","abstract":"This thesis investigates the interaction between GsAF-I, a peptide from the venom of the tarantula Grammostola rosea, and human voltage-gated proton (Hv1) channels, critical in pH regulation and cellular signaling. Utilizing patch clamp techniques on genetically modified Chinese Hamster Ovary cells expressing human Hv1, the study revealed that GsAF-I significantly stabilizes the closed state of these channels, thereby delaying their opening and hastening their closure, with these effects being notably voltage-dependent. The fast onset and reversibility of GsAF-I's actions suggest its potential for therapeutic use, particularly in treating conditions associated with abnormal proton flux, such as cancer and inflammation. These findings underscore the therapeutic promise of tarantula-derived peptides in modulating ion channel activity and contributing to new treatments for diseases involving disrupted proton flux.","abstract_html":"This thesis investigates the interaction between GsAF-I, a peptide from the venom of the tarantula Grammostola rosea, and human voltage-gated proton (Hv1) channels, critical in pH regulation and cellular signaling. Utilizing patch clamp techniques on genetically modified Chinese Hamster Ovary cells expressing human Hv1, the study revealed that GsAF-I significantly stabilizes the closed state of these channels, thereby delaying their opening and hastening their closure, with these effects being notably voltage-dependent. The fast onset and reversibility of GsAF-I's actions suggest its potential for therapeutic use, particularly in treating conditions associated with abnormal proton flux, such as cancer and inflammation. These findings underscore the therapeutic promise of tarantula-derived peptides in modulating ion channel activity and contributing to new treatments for diseases involving disrupted proton flux.","abstract_has_math":false,"creators":["Rahpeymaei, Ali"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"DE--Gyógyszerésztudományi Kar","school":null,"contributors":[],"advisors":["Papp, Ferenc"],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"","date_published":null,"updated_at":"2026-07-27T19:13:39Z","subjects":["Hv1, Peptide ,Novel drug ,Voltage gated"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2437/369064","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Papp, Ferenc"]},{"key":"dc:contributor.department","label":"Department","values":["DE--Gyógyszerésztudományi Kar"]},{"key":"dc:creator","label":"Author","values":["Rahpeymaei, Ali"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-04-19T10:13:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-04-19T10:13:42Z"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Hv1, Peptide ,Novel drug ,Voltage gated"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/2437/369064"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This thesis investigates the interaction between GsAF-I, a peptide from the venom of the tarantula Grammostola rosea, and human voltage-gated proton (Hv1) channels, critical in pH regulation and cellular signaling. Utilizing patch clamp techniques on genetically modified Chinese Hamster Ovary cells expressing human Hv1, the study revealed that GsAF-I significantly stabilizes the closed state of these channels, thereby delaying their opening and hastening their closure, with these effects being notably voltage-dependent. The fast onset and reversibility of GsAF-I's actions suggest its potential for therapeutic use, particularly in treating conditions associated with abnormal proton flux, such as cancer and inflammation. These findings underscore the therapeutic promise of tarantula-derived peptides in modulating ion channel activity and contributing to new treatments for diseases involving disrupted proton flux."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["egységes, osztatlan"]},{"key":"dc:title","label":"Title","values":["Hv1 novel peptide inhibitor extracted from tarantula venom"]}]}],"canonical_facts":{"dc:contributor.advisor":["Papp, Ferenc"],"dc:contributor.department":["DE--Gyógyszerésztudományi Kar"],"dc:creator":["Rahpeymaei, Ali"],"dc:date.accessioned":["2024-04-19T10:13:42Z"],"dc:date.available":["2024-04-19T10:13:42Z"],"dc:description.abstract":["This thesis investigates the interaction between GsAF-I, a peptide from the venom of the tarantula Grammostola rosea, and human voltage-gated proton (Hv1) channels, critical in pH regulation and cellular signaling. Utilizing patch clamp techniques on genetically modified Chinese Hamster Ovary cells expressing human Hv1, the study revealed that GsAF-I significantly stabilizes the closed state of these channels, thereby delaying their opening and hastening their closure, with these effects being notably voltage-dependent. The fast onset and reversibility of GsAF-I's actions suggest its potential for therapeutic use, particularly in treating conditions associated with abnormal proton flux, such as cancer and inflammation. These findings underscore the therapeutic promise of tarantula-derived peptides in modulating ion channel activity and contributing to new treatments for diseases involving disrupted proton flux."],"dc:description.degree":["egységes, osztatlan"],"dc:identifier.uri":["https://hdl.handle.net/2437/369064"],"dc:language.iso":["en"],"dc:subject":["Hv1, Peptide ,Novel drug ,Voltage gated"],"dc:title":["Hv1 novel peptide inhibitor extracted from tarantula venom"]},"updated_at":"2026-07-27T19:13:39Z"}