{"id":{"repo_id":"debrecen","oai_identifier":"oai:dea.lib.unideb.hu:2437/284483"},"canonical_url":"https://search.dev.ndltd.org/etd/debrecen/oai:dea.lib.unideb.hu:2437/284483","repository":{"repo_id":"debrecen","name":"University of Debrecen","base_url":"https://dea.lib.unideb.hu/server/oai/request"},"display":{"title":"Role of biological mediators in periodontal healing responses","abstract":"During wound healing, cells situated in the periodontal ligament communicate with each other and induce the healing process. The periodontal ligament stem cells migrate to the inflamed site and differentiate into mesenchymal origin cells in response to chemokines. Various mediators induce the healing process, such as interleukins, PDGF, TGF-b, IGF- 1, FGF-2, VEGF, and EGF. Non-coding RNAs have been found to be associated with inflammatory reactions including periodontal diseases. The important functions of cytokines and the gene expression levels in regulating PDL cells has given researchers more ideas and possibilities to use them as regenerative agents. Biological mediators are potential therapeutic agents for periodontal regeneration.","abstract_html":"During wound healing, cells situated in the periodontal ligament communicate with each other and induce the healing process. The periodontal ligament stem cells migrate to the inflamed site and differentiate into mesenchymal origin cells in response to chemokines. Various mediators induce the healing process, such as interleukins, PDGF, TGF-b, IGF- 1, FGF-2, VEGF, and EGF. Non-coding RNAs have been found to be associated with inflammatory reactions including periodontal diseases. The important functions of cytokines and the gene expression levels in regulating PDL cells has given researchers more ideas and possibilities to use them as regenerative agents. Biological mediators are potential therapeutic agents for periodontal regeneration.","abstract_has_math":false,"creators":["Matthíasdóttir, Rebekka"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"DE--Fogorvostudományi Kar","school":null,"contributors":[],"advisors":["Angyal, János"],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"","date_published":null,"updated_at":"2026-07-27T19:13:41Z","subjects":["biological mediators","periodontal","wound healing"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2437/284483","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Angyal, János"]},{"key":"dc:contributor.department","label":"Department","values":["DE--Fogorvostudományi Kar"]},{"key":"dc:creator","label":"Author","values":["Matthíasdóttir, Rebekka"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-04-24T06:37:09Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-04-24T06:37:09Z"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["biological mediators","periodontal","wound healing"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2437/284483"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["During wound healing, cells situated in the periodontal ligament communicate with each other and induce the healing process. The periodontal ligament stem cells migrate to the inflamed site and differentiate into mesenchymal origin cells in response to chemokines. Various mediators induce the healing process, such as interleukins, PDGF, TGF-b, IGF- 1, FGF-2, VEGF, and EGF. Non-coding RNAs have been found to be associated with inflammatory reactions including periodontal diseases. The important functions of cytokines and the gene expression levels in regulating PDL cells has given researchers more ideas and possibilities to use them as regenerative agents. Biological mediators are potential therapeutic agents for periodontal regeneration."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["egységes, osztatlan"]},{"key":"dc:title","label":"Title","values":["Role of biological mediators in periodontal healing responses"]}]}],"canonical_facts":{"dc:contributor.advisor":["Angyal, János"],"dc:contributor.department":["DE--Fogorvostudományi Kar"],"dc:creator":["Matthíasdóttir, Rebekka"],"dc:date.accessioned":["2020-04-24T06:37:09Z"],"dc:date.available":["2020-04-24T06:37:09Z"],"dc:description.abstract":["During wound healing, cells situated in the periodontal ligament communicate with each other and induce the healing process. The periodontal ligament stem cells migrate to the inflamed site and differentiate into mesenchymal origin cells in response to chemokines. Various mediators induce the healing process, such as interleukins, PDGF, TGF-b, IGF- 1, FGF-2, VEGF, and EGF. Non-coding RNAs have been found to be associated with inflammatory reactions including periodontal diseases. The important functions of cytokines and the gene expression levels in regulating PDL cells has given researchers more ideas and possibilities to use them as regenerative agents. Biological mediators are potential therapeutic agents for periodontal regeneration."],"dc:description.degree":["egységes, osztatlan"],"dc:identifier.uri":["http://hdl.handle.net/2437/284483"],"dc:language.iso":["en"],"dc:subject":["biological mediators","periodontal","wound healing"],"dc:title":["Role of biological mediators in periodontal healing responses"]},"updated_at":"2026-07-27T19:13:41Z"}