Development of a Broad Spectrum, Sporicidal, Cost Saving Disinfectant Incorporating a Novel Antimicrobial Catalyst
type: CreativeWork
description: Introduction: Hospital infections are still a major burden within the health care sector. Without adequate infection control procedures such as hand washing and disinfection, this can lead to morbidity and mortality in the extremely ill or immunocompromised patients. A novel heterogeneous polyacrylonitrile (PAN) fibre catalyst, produced by De Montfort University and impregnated with ferric sulfate has been previously shown to have potent antimicrobial activity against bacteria, when used in conjunction with hydrogen peroxide (H2O2). The aims of this research were to develop a sporicidal technology to help combat hospital acquired infections; develop a strong, flexible and absorbent catalyst for liquid and gaseous applications; establish the antimicrobial activity of the novel antimicrobial catalyst against bacteria using gaseous H2O2; and to establish the leachate antimicrobial activity. Methods: The Methods used were modified British Standard Suspension tests for basic sporocidal, bactericidal, mycobactericidal and yeasticidal activity. Ammonia testing was done using the Hach-Lange cuvette system, while hydrazine and hydroxylamine were tested using modified spectrophotometric tests. Iron was analysed using atomic absorption spectrophotometry. Modified membrane experiments were based on methods from Carson et al. (2002), Chen and Cooper (2002), Garcia et al. (2006) and Fisher and Philips (2009). Applications were tested using suspension tests, high pressure liquid chromatography (one-step application) or using the BioQuell, UK testing criteria (vaporised hydrogen peroxide). Results and Discussions: The PAN catalyst and H2O2 system had a significantly greater sporicidal, mycobactericidal and fungicidal activity, compared to H2O2 alone (p<0.05) which further increased when the catalyst to H2O2 ratio was increased (p<0.01). The leachate after one-use, in conjuncion with H2O2, was found to be equal in activity to the PAN catalyst and H2O2 system, with no significant dif…
abstract: Introduction: Hospital infections are still a major burden within the health care sector. Without adequate infection control procedures such as hand washing and disinfection, this can lead to morbidity and mortality in the extremely ill or immunocompromised patients. A novel heterogeneous polyacrylonitrile (PAN) fibre catalyst, produced by De Montfort University and impregnated with ferric sulfate has been previously shown to have potent antimicrobial activity against bacteria, when used in conjunction with hydrogen peroxide (H2O2). The aims of this research were to develop a sporicidal technology to help combat hospital acquired infections; develop a strong, flexible and absorbent catalyst for liquid and gaseous applications; establish the antimicrobial activity of the novel antimicrobial catalyst against bacteria using gaseous H2O2; and to establish the leachate antimicrobial activity. Methods: The Methods used were modified British Standard Suspension tests for basic sporocidal, bactericidal, mycobactericidal and yeasticidal activity. Ammonia testing was done using the Hach-Lange cuvette system, while hydrazine and hydroxylamine were tested using modified spectrophotometric tests. Iron was analysed using atomic absorption spectrophotometry. Modified membrane experiments were based on methods from Carson et al. (2002), Chen and Cooper (2002), Garcia et al. (2006) and Fisher and Philips (2009). Applications were tested using suspension tests, high pressure liquid chromatography (one-step application) or using the BioQuell, UK testing criteria (vaporised hydrogen peroxide). Results and Discussions: The PAN catalyst and H2O2 system had a significantly greater sporicidal, mycobactericidal and fungicidal activity, compared to H2O2 alone (p<0.05) which further increased when the catalyst to H2O2 ratio was increased (p<0.01). The leachate after one-use, in conjuncion with H2O2, was found to be equal in activity to the PAN catalyst and H2O2 system, with no significant dif…
author: Price, Samantha Louise
license: https://dora.dmu.ac.uk/bitstreams/66811eb2-1b03-4e30-88fa-e4ae54591b8b/download
date published: 2013-07-29
date modified: 2026-07-24T06:18:56Z
provider: De Montfort University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: De Montfort University