Development of light actuated chemical delivery platform on a 2-D array of micropore structure
Localized chemical delivery plays an essential role in the fundamental information transfers within biological systems. Thus, the ability to mimic the natural chemical signal modulation would provide significant contributions to understand the functional signaling pathway of biological cells and develop new prosthetic devices for neurological disorders. In this paper, we demonstrate a light-controlled hydrogel platform that can be used for localized chemical delivery in a high spatial resolution. By utilizing the photothermal behavior of graphene-hydrogel composites confined within micron-sized fluidic channels, patterned light illumination creates the parallel and independent actuation of chemical release in a group of fluidic ports. The new platform promises the feasibility of creating a novel synaptic interface with large arrayed chemical stimulation capability toward biochemically controlled neural prosthesis systems.
chemical stimulation, Thermo responsive hydrogel, Photothermal, Macroporous silicon membrane, graphene nanoplatelets, Arrayed sensor, Valveless micropump, Polypyrrole, Liquid flow control, Low voltage actuation, local chemical delivery, Biochemical and Biomolecular Engineering, Biochemistry, Bioelectrical and Neuroengineering, Bioimaging and Biomedical Optics, Biological Engineering, Biology and Biomimetic Materials, Biomaterials, Biomechanical Engineering, Biomechanics and Biotransport, Biomedical, Biomedical Devices and Instrumentation, Dynamics and Dynamical Systems, Electromagnetics and Photonics, Electronic Devices and Semiconductor Manufacturing, Eye Diseases, Medical Biotechnology, Molecular, Cellular, and Tissue Engineering, Nanomedicine, Nanoscience and Nanotechnology, Nanotechnology Fabrication, Other Biomedical Engineering and Bioengineering, Other Chemicals and Drugs, Polymer and Organic Materials, Polymer Science, Semiconductor and Optical Materials, Structural Materials, Systems and Integrative Engineering, Transport Phenomena, Vision Science
City University of New York - City College
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