Extinction of Threat Memory via Reconsolidation Interference: A Behavioral Intervention Meta-Analysis
type: CreativeWork
description: Threat memories are created when an aversive stimulus is paired with other stimuli such that the associated stimuli elicit the same reaction as the unpleasant one. Anxiety disorders are usually treated with exposure to aversive stimuli. Emotional memories can be altered through a process called reconsolidation interference. Consolidated memories are dynamic: reminders of previous experiences prompt the reactivation of a previously-encoded memory; destabilization of the memory opens it to update. While a memory is updating, it is labile. If extinction training occurs during reconsolidation (i.e., shortly after reactivation), the conditioned stimulus will no longer elicit the conditioned response. Thus, previously-encoded threat memories can be weakened through the process of reconsolidation. Maximizing the long-term positive effects of reconsolidation interference by delivering extinction training during the reconsolidation window has the potential to revolutionize the treatment of anxiety disorders. Yet, the results of studies that behaviorally manipulate reconsolidation have proven difficult to replicate. Kredlow and colleagues’ (2016) comprehensive meta-analysis on aversive and appetitive memory reconsolidation in rodents and humans showed a small-to-moderate effect for the interference of human threat-memory reconsolidation (g = 0.40, n = 16, p < .01). The current paper is a verification and expansion of Kredlow and colleagues’ (2016) analyses on post-reactivation extinction of human threat memories. The analysis verifying the original study failed to replicate the overall effect (g = 0.3144, n=16, p = 0.0646), though moderators were similar in terms of impact on effect and statistical significance; specifically, the number of acquisition trials and inclusion of expectancy-of-aversive-outcome ratings were significant moderators on effect. With a larger number of studies (n = 26), the expanded analysis yielded a smaller, albeit significant (p = 0.0138), overall ef…
abstract: Threat memories are created when an aversive stimulus is paired with other stimuli such that the associated stimuli elicit the same reaction as the unpleasant one. Anxiety disorders are usually treated with exposure to aversive stimuli. Emotional memories can be altered through a process called reconsolidation interference. Consolidated memories are dynamic: reminders of previous experiences prompt the reactivation of a previously-encoded memory; destabilization of the memory opens it to update. While a memory is updating, it is labile. If extinction training occurs during reconsolidation (i.e., shortly after reactivation), the conditioned stimulus will no longer elicit the conditioned response. Thus, previously-encoded threat memories can be weakened through the process of reconsolidation. Maximizing the long-term positive effects of reconsolidation interference by delivering extinction training during the reconsolidation window has the potential to revolutionize the treatment of anxiety disorders. Yet, the results of studies that behaviorally manipulate reconsolidation have proven difficult to replicate. Kredlow and colleagues’ (2016) comprehensive meta-analysis on aversive and appetitive memory reconsolidation in rodents and humans showed a small-to-moderate effect for the interference of human threat-memory reconsolidation (g = 0.40, n = 16, p < .01). The current paper is a verification and expansion of Kredlow and colleagues’ (2016) analyses on post-reactivation extinction of human threat memories. The analysis verifying the original study failed to replicate the overall effect (g = 0.3144, n=16, p = 0.0646), though moderators were similar in terms of impact on effect and statistical significance; specifically, the number of acquisition trials and inclusion of expectancy-of-aversive-outcome ratings were significant moderators on effect. With a larger number of studies (n = 26), the expanded analysis yielded a smaller, albeit significant (p = 0.0138), overall ef…
author: Andrae, Chris M
keywords: Cognitive Science, Social and Behavioral Sciences, reconsolidation update, reconsolidation interference, post-retrieval extinction, threat memory, fear memory, meta-analysis
date published: 2023-06-01T07:00:00Z
date modified: 2026-07-24T02:00:26Z
provider: City University of New York - Graduate Center
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: The Graduate School and University Center of The City University of New York