Objective: The purpose of this investigation is to perform a systematic review of the existing literature on NAC efficacy in prevention of cisplatin-induced ototoxicity.
Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City University of New York was conducted to identify relevant studies for analysis. The levels of evidence were applied to restrict articles reviewed to Level 3 or better.
Results: Eight articles evaluating NAC protective efficacy against cisplatin-induced ototoxicity were identified. The results revealed significant variability in NAC otoprotective efficacy.
Discussion: The significant variability in findings on NAC otoprotective efficacy may reflect lack of uniformity in the study methodologies and the limited number of clinical trials. Randomized clinical trials are needed on NAC otoprotective efficacy.
Conclusions: The findings of the reviewed studies show promise in preventing otologic damage with the use of NAC. Nonetheless, based on the currently available evidence, no recommendations for clinical practice can be made at this time.
","abstract_html":"<p>Objective: The purpose of this investigation is to perform a systematic review of the existing literature on NAC efficacy in prevention of cisplatin-induced ototoxicity.</p> <p>Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City University of New York was conducted to identify relevant studies for analysis. The levels of evidence were applied to restrict articles reviewed to Level 3 or better.</p> <p>Results: Eight articles evaluating NAC protective efficacy against cisplatin-induced ototoxicity were identified. The results revealed significant variability in NAC otoprotective efficacy.</p> <p>Discussion: The significant variability in findings on NAC otoprotective efficacy may reflect lack of uniformity in the study methodologies and the limited number of clinical trials. Randomized clinical trials are needed on NAC otoprotective efficacy.</p> <p>Conclusions: The findings of the reviewed studies show promise in preventing otologic damage with the use of NAC. Nonetheless, based on the currently available evidence, no recommendations for clinical practice can be made at this time.</p>","abstract_has_math":false,"creators":["Peravozchykava, Maryana"],"institution":"The Graduate School and University Center of The City University of New York","degree_name":"Doctor of Audiology","degree_level":"Doctoral","degree_discipline":"Audiology","degree_department":null,"school":null,"contributors":[],"advisors":["Carol A. Silverman"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-06-03T07:00:00Z","date_published":"2014-06-03T07:00:00Z","updated_at":"2026-07-24T01:59:05Z","subjects":["Speech Pathology and Audiology","N-acetylcysteine","cisplatin","ototoxicity","otoprotection","sensorineural hearing loss"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://academicworks.cuny.edu/gc_etds/800","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Carol A. Silverman"]},{"key":"dc:creator","label":"Author","values":["Peravozchykava, Maryana"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2014-06-03T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Audiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Audiology"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["The Graduate School and University Center of The City University of New York"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Speech Pathology and Audiology","N-acetylcysteine","cisplatin","ototoxicity","otoprotection","sensorineural hearing loss"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://academicworks.cuny.edu/gc_etds/800"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Objective: The purpose of this investigation is to perform a systematic review of the existing literature on NAC efficacy in prevention of cisplatin-induced ototoxicity.
Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City University of New York was conducted to identify relevant studies for analysis. The levels of evidence were applied to restrict articles reviewed to Level 3 or better.
Results: Eight articles evaluating NAC protective efficacy against cisplatin-induced ototoxicity were identified. The results revealed significant variability in NAC otoprotective efficacy.
Discussion: The significant variability in findings on NAC otoprotective efficacy may reflect lack of uniformity in the study methodologies and the limited number of clinical trials. Randomized clinical trials are needed on NAC otoprotective efficacy.
Conclusions: The findings of the reviewed studies show promise in preventing otologic damage with the use of NAC. Nonetheless, based on the currently available evidence, no recommendations for clinical practice can be made at this time.
"]},{"key":"dc:title","label":"Title","values":["Efficacy of N-acetylcysteine on Prevention and Amelioration of Cisplatin-induced Ototoxicity: A Systematic Literature Review"]}]}],"canonical_facts":{"dc:contributor.advisor":["Carol A. Silverman"],"dc:creator":["Peravozchykava, Maryana"],"dc:date.available":["2014-06-03T07:00:00Z"],"dc:description.abstract":["Objective: The purpose of this investigation is to perform a systematic review of the existing literature on NAC efficacy in prevention of cisplatin-induced ototoxicity.
Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City University of New York was conducted to identify relevant studies for analysis. The levels of evidence were applied to restrict articles reviewed to Level 3 or better.
Results: Eight articles evaluating NAC protective efficacy against cisplatin-induced ototoxicity were identified. The results revealed significant variability in NAC otoprotective efficacy.
Discussion: The significant variability in findings on NAC otoprotective efficacy may reflect lack of uniformity in the study methodologies and the limited number of clinical trials. Randomized clinical trials are needed on NAC otoprotective efficacy.
Conclusions: The findings of the reviewed studies show promise in preventing otologic damage with the use of NAC. Nonetheless, based on the currently available evidence, no recommendations for clinical practice can be made at this time.
"],"dc:identifier":["https://academicworks.cuny.edu/gc_etds/800"],"dc:subject":["Speech Pathology and Audiology","N-acetylcysteine","cisplatin","ototoxicity","otoprotection","sensorineural hearing loss"],"dc:title":["Efficacy of N-acetylcysteine on Prevention and Amelioration of Cisplatin-induced Ototoxicity: A Systematic Literature Review"],"thesis:degree_discipline":["Audiology"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Doctor of Audiology"],"thesis:institution_name":["The Graduate School and University Center of The City University of New York"]},"updated_at":"2026-07-24T01:59:05Z"}