Surface Modified Solid Lipid Curcumin Nanoparticles For Oral Delivery
type: CreativeWork
description: Curcumin is a naturally available polyphenolic compound that has demonstrated chemotherapeutic effects in several carcinogenic models as well as pre-clinical trials. However, its poor oral bioavailability due to extremely low aqueous solubility, poor permeability and extensive pre-systemic metabolism has been the major limitation for its use as a chemotherapeutic agent. Solid lipid nanoparticulate formulations have been successfully used to enhance the oral bioavailability of several poorly soluble drugs. The objective of the present research was to develop and characterize solid lipid nanoparticles for oral delivery of curcumin using GMO/chitosan based nanoparticulate system containing two different stabilizers. |The oil/water nanoemulsions were prepared by sonication and high pressure homogenization (HPH) using GMO/chitosan system. Two different stabilizers namely, PVA and poloxamer 407 were used for this purpose. The particles size (PS) and zeta potential (ZP) of nanoemulsion were determined at different stages of preparation using zetameter. The physical stability of the nanoemulsion was studied at 25⁰C over a period of 60 days by determining its PS and ZP. The blank and curcumin loaded nanoemulsions of both PVA as well as poloxamer containing formulations were further lyophilized and characterized for PS and ZP. The surface morphology of drug loaded nanostructures was determined using scanning electron microscopy. The weight loss of these formulations on heating was investigated using thermogravimetry while the moisture content was determined using Karl Fischer titrimetry. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis was performed to determine the physical state of the drug in the nanostructures. An UPLC method was developed and validated for the analysis of curcumin. The in vitro release of curcumin from the nanostructures was evaluated at 37⁰C in pH 7.4 buffer containing 0.5% (w/v) Tween 80 by using UPLC. The cellular uptake of…
abstract: Curcumin is a naturally available polyphenolic compound that has demonstrated chemotherapeutic effects in several carcinogenic models as well as pre-clinical trials. However, its poor oral bioavailability due to extremely low aqueous solubility, poor permeability and extensive pre-systemic metabolism has been the major limitation for its use as a chemotherapeutic agent. Solid lipid nanoparticulate formulations have been successfully used to enhance the oral bioavailability of several poorly soluble drugs. The objective of the present research was to develop and characterize solid lipid nanoparticles for oral delivery of curcumin using GMO/chitosan based nanoparticulate system containing two different stabilizers. |The oil/water nanoemulsions were prepared by sonication and high pressure homogenization (HPH) using GMO/chitosan system. Two different stabilizers namely, PVA and poloxamer 407 were used for this purpose. The particles size (PS) and zeta potential (ZP) of nanoemulsion were determined at different stages of preparation using zetameter. The physical stability of the nanoemulsion was studied at 25⁰C over a period of 60 days by determining its PS and ZP. The blank and curcumin loaded nanoemulsions of both PVA as well as poloxamer containing formulations were further lyophilized and characterized for PS and ZP. The surface morphology of drug loaded nanostructures was determined using scanning electron microscopy. The weight loss of these formulations on heating was investigated using thermogravimetry while the moisture content was determined using Karl Fischer titrimetry. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis was performed to determine the physical state of the drug in the nanostructures. An UPLC method was developed and validated for the analysis of curcumin. The in vitro release of curcumin from the nanostructures was evaluated at 37⁰C in pH 7.4 buffer containing 0.5% (w/v) Tween 80 by using UPLC. The cellular uptake of…
author: Mistry, Pinal
language: en_US
date published: 2011-08
date modified: 2026-07-24T01:49:51Z
provider: Creighton University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Creighton University

PropertyValue
property ID: Handle
value: http://hdl.handle.net/10504/18915