{"id":{"repo_id":"creighton","oai_identifier":"oai:cdr.creighton.edu:10504/118417"},"canonical_url":"https://search.dev.ndltd.org/etd/creighton/oai:cdr.creighton.edu:10504/118417","repository":{"repo_id":"creighton","name":"Creighton University","base_url":"https://cdr.creighton.edu/server/oai/request"},"display":{"title":"Studies on the Role of Vitamin D in the Mineralization of Bone: A Vitamin D-dependent Serum Protein That Stimulates the Incorporation of 45 Calcium by Bone Cells in Vitro","abstract":"Research in the 1920's established that rickets, a bone disease in which newly synthesized osteoid matrix does not calcify, was caused by a dietary deficiency in the fat-soluble vitamin D. These investigators concluded that vitamin D was necessary for the normal mineralization of bone. After 50 years of study the exact role of vitamin D in the mineralization process is still obscure. | A major problem in determining the mode of action of vitamin D on the mineralization of bone is that the cellular and molecular mechanisms of bone mineralization are unknown. | Historically, bone mineralization was considered to be a physicochemical process which depended on an adequate supply of Ca+2 and HP04-2 ions in extracellular fluid for the spontaneous precipitation of bone mineral. The impaired mineralization that was observed in a vitamin D-deficiency was probably a result of the lower Ca+2 and/or HPO4-2 concentrations in blood which were also mirrored in the fluids bathing the bone. Vitamin D was considered to be indirectly involved in bone mineralization through the regulation of blood Ca+2 and/or HPO4-2 levels.","abstract_html":"Research in the 1920's established that rickets, a bone disease in which newly synthesized osteoid matrix does not calcify, was caused by a dietary deficiency in the fat-soluble vitamin D. These investigators concluded that vitamin D was necessary for the normal mineralization of bone. After 50 years of study the exact role of vitamin D in the mineralization process is still obscure. | A major problem in determining the mode of action of vitamin D on the mineralization of bone is that the cellular and molecular mechanisms of bone mineralization are unknown. | Historically, bone mineralization was considered to be a physicochemical process which depended on an adequate supply of Ca+2 and HP04-2 ions in extracellular fluid for the spontaneous precipitation of bone mineral. The impaired mineralization that was observed in a vitamin D-deficiency was probably a result of the lower Ca+2 and/or HPO4-2 concentrations in blood which were also mirrored in the fluids bathing the bone. Vitamin D was considered to be indirectly involved in bone mineralization through the regulation of blood Ca+2 and/or HPO4-2 levels.","abstract_has_math":false,"creators":["Pattee, John Robert"],"institution":"Creighton University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Gambal, David"],"committee_chairs":[],"committee_members":[],"year":1975,"date_issued":"1975","date_published":"1975","updated_at":"2026-07-24T01:50:57Z","subjects":[],"languages":["en_US"],"rights":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10504/118417","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Gambal, David"]},{"key":"dc:creator","label":"Author","values":["Pattee, John Robert"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-06-18T16:50:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-06-18T16:50:42Z"]},{"key":"dc:date.issued","label":"Date","values":["1975"]},{"key":"dc:publisher","label":"Institution","values":["Creighton University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10504/118417"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Research in the 1920's established that rickets, a bone disease in which newly synthesized osteoid matrix does not calcify, was caused by a dietary deficiency in the fat-soluble vitamin D. These investigators concluded that vitamin D was necessary for the normal mineralization of bone. After 50 years of study the exact role of vitamin D in the mineralization process is still obscure. | A major problem in determining the mode of action of vitamin D on the mineralization of bone is that the cellular and molecular mechanisms of bone mineralization are unknown. | Historically, bone mineralization was considered to be a physicochemical process which depended on an adequate supply of Ca+2 and HP04-2 ions in extracellular fluid for the spontaneous precipitation of bone mineral. The impaired mineralization that was observed in a vitamin D-deficiency was probably a result of the lower Ca+2 and/or HPO4-2 concentrations in blood which were also mirrored in the fluids bathing the bone. Vitamin D was considered to be indirectly involved in bone mineralization through the regulation of blood Ca+2 and/or HPO4-2 levels."]},{"key":"dc:title","label":"Title","values":["Studies on the Role of Vitamin D in the Mineralization of Bone: A Vitamin D-dependent Serum Protein That Stimulates the Incorporation of 45 Calcium by Bone Cells in Vitro"]}]}],"canonical_facts":{"dc:contributor.advisor":["Gambal, David"],"dc:creator":["Pattee, John Robert"],"dc:date.accessioned":["2018-06-18T16:50:42Z"],"dc:date.available":["2018-06-18T16:50:42Z"],"dc:date.issued":["1975"],"dc:description.abstract":["Research in the 1920's established that rickets, a bone disease in which newly synthesized osteoid matrix does not calcify, was caused by a dietary deficiency in the fat-soluble vitamin D. These investigators concluded that vitamin D was necessary for the normal mineralization of bone. After 50 years of study the exact role of vitamin D in the mineralization process is still obscure. | A major problem in determining the mode of action of vitamin D on the mineralization of bone is that the cellular and molecular mechanisms of bone mineralization are unknown. | Historically, bone mineralization was considered to be a physicochemical process which depended on an adequate supply of Ca+2 and HP04-2 ions in extracellular fluid for the spontaneous precipitation of bone mineral. The impaired mineralization that was observed in a vitamin D-deficiency was probably a result of the lower Ca+2 and/or HPO4-2 concentrations in blood which were also mirrored in the fluids bathing the bone. Vitamin D was considered to be indirectly involved in bone mineralization through the regulation of blood Ca+2 and/or HPO4-2 levels."],"dc:identifier.uri":["http://hdl.handle.net/10504/118417"],"dc:language.iso":["en_US"],"dc:publisher":["Creighton University"],"dc:rights":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."],"dc:title":["Studies on the Role of Vitamin D in the Mineralization of Bone: A Vitamin D-dependent Serum Protein That Stimulates the Incorporation of 45 Calcium by Bone Cells in Vitro"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T01:50:57Z"}