{"id":{"repo_id":"creighton","oai_identifier":"oai:cdr.creighton.edu:10504/117992"},"canonical_url":"https://search.dev.ndltd.org/etd/creighton/oai:cdr.creighton.edu:10504/117992","repository":{"repo_id":"creighton","name":"Creighton University","base_url":"https://cdr.creighton.edu/server/oai/request"},"display":{"title":"Non-Antibiotic Effects of Macrolide Antibiotics of the Oleandomycin-Erythromycin Group With Special Reference to Their \"Steroid-sparing\" Effects","abstract":"Previous papers in the literature reported the effectiveness of triacetyloleandomycin, a macrolide antibiotic, in the treatment of bronchial asthma. The beneficial effects were attributed to the antimicrobial characteristics of this compound. However, the antiasthmatic activity of the drug was found by Towniey et al. 14-18 to be retained in selected cases of asthmatics in the absence of clinically apparent or verifiable infections. | For this reason, I have undertaken to examine in animal experiments whether the anti-asthmatic activity of this and other macrolide antibiotics could be due to the possible steroid-like properties of these substances. As described below, I have concluded that the anti-asthmatic activity of these agents could be more easily explained at present by a steroid-sparing mechanism rather than by the possession of genuine steroid-like properties.","abstract_html":"Previous papers in the literature reported the effectiveness of triacetyloleandomycin, a macrolide antibiotic, in the treatment of bronchial asthma. The beneficial effects were attributed to the antimicrobial characteristics of this compound. However, the antiasthmatic activity of the drug was found by Towniey et al. 14-18 to be retained in selected cases of asthmatics in the absence of clinically apparent or verifiable infections. | For this reason, I have undertaken to examine in animal experiments whether the anti-asthmatic activity of this and other macrolide antibiotics could be due to the possible steroid-like properties of these substances. As described below, I have concluded that the anti-asthmatic activity of these agents could be more easily explained at present by a steroid-sparing mechanism rather than by the possession of genuine steroid-like properties.","abstract_has_math":false,"creators":["Selenke, William Michael"],"institution":"Creighton University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Townley, Robert G."],"committee_chairs":[],"committee_members":[],"year":1970,"date_issued":"1970","date_published":"1970","updated_at":"2026-07-24T01:52:03Z","subjects":["Microbiology"],"languages":["en_US"],"rights":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10504/117992","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Townley, Robert G."]},{"key":"dc:creator","label":"Author","values":["Selenke, William Michael"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-05-25T17:29:09Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-05-25T17:29:09Z"]},{"key":"dc:date.issued","label":"Date","values":["1970"]},{"key":"dc:publisher","label":"Institution","values":["Creighton University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Microbiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10504/117992"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Previous papers in the literature reported the effectiveness of triacetyloleandomycin, a macrolide antibiotic, in the treatment of bronchial asthma. The beneficial effects were attributed to the antimicrobial characteristics of this compound. However, the antiasthmatic activity of the drug was found by Towniey et al. 14-18 to be retained in selected cases of asthmatics in the absence of clinically apparent or verifiable infections. | For this reason, I have undertaken to examine in animal experiments whether the anti-asthmatic activity of this and other macrolide antibiotics could be due to the possible steroid-like properties of these substances. As described below, I have concluded that the anti-asthmatic activity of these agents could be more easily explained at present by a steroid-sparing mechanism rather than by the possession of genuine steroid-like properties."]},{"key":"dc:title","label":"Title","values":["Non-Antibiotic Effects of Macrolide Antibiotics of the Oleandomycin-Erythromycin Group With Special Reference to Their \"Steroid-sparing\" Effects"]}]}],"canonical_facts":{"dc:contributor.advisor":["Townley, Robert G."],"dc:creator":["Selenke, William Michael"],"dc:date.accessioned":["2018-05-25T17:29:09Z"],"dc:date.available":["2018-05-25T17:29:09Z"],"dc:date.issued":["1970"],"dc:description.abstract":["Previous papers in the literature reported the effectiveness of triacetyloleandomycin, a macrolide antibiotic, in the treatment of bronchial asthma. The beneficial effects were attributed to the antimicrobial characteristics of this compound. However, the antiasthmatic activity of the drug was found by Towniey et al. 14-18 to be retained in selected cases of asthmatics in the absence of clinically apparent or verifiable infections. | For this reason, I have undertaken to examine in animal experiments whether the anti-asthmatic activity of this and other macrolide antibiotics could be due to the possible steroid-like properties of these substances. As described below, I have concluded that the anti-asthmatic activity of these agents could be more easily explained at present by a steroid-sparing mechanism rather than by the possession of genuine steroid-like properties."],"dc:identifier.uri":["http://hdl.handle.net/10504/117992"],"dc:language.iso":["en_US"],"dc:publisher":["Creighton University"],"dc:rights":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."],"dc:subject":["Microbiology"],"dc:title":["Non-Antibiotic Effects of Macrolide Antibiotics of the Oleandomycin-Erythromycin Group With Special Reference to Their \"Steroid-sparing\" Effects"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T01:52:03Z"}