{"id":{"repo_id":"creighton","oai_identifier":"oai:cdr.creighton.edu:10504/115998"},"canonical_url":"https://search.dev.ndltd.org/etd/creighton/oai:cdr.creighton.edu:10504/115998","repository":{"repo_id":"creighton","name":"Creighton University","base_url":"https://cdr.creighton.edu/server/oai/request"},"display":{"title":"The Influence of Certain Lytic Agents on the Oxygen Consumption of Dog Erythrocytes","abstract":"The hemolytic action of methylene blue was reported in 1924 by Huyghabaert. Doge developed anemia following the admlnistration of the dye and methylene blue was shown to produce hemolysis in vitro (l). In 1934, Wendel and Hefley observed the hemolytic property of the dye and suggested its use in the treatment of polycythemia (2). Olivier, in 1939, reported a ease of polycythemia which he treated with methylene blue. A reduction in the patient's red blood cell count was obtained but further studies were impossible when the patient became lost in the confusion of the war (3). Investigation of methylene blue as a chemotherapeutic agent again revealed its hemolytic action. Mice were successfully treated with the dye for Tsutsugamushi disease but subsequently developed anemia (4).","abstract_html":"The hemolytic action of methylene blue was reported in 1924 by Huyghabaert. Doge developed anemia following the admlnistration of the dye and methylene blue was shown to produce hemolysis in vitro (l). In 1934, Wendel and Hefley observed the hemolytic property of the dye and suggested its use in the treatment of polycythemia (2). Olivier, in 1939, reported a ease of polycythemia which he treated with methylene blue. A reduction in the patient's red blood cell count was obtained but further studies were impossible when the patient became lost in the confusion of the war (3). Investigation of methylene blue as a chemotherapeutic agent again revealed its hemolytic action. Mice were successfully treated with the dye for Tsutsugamushi disease but subsequently developed anemia (4).","abstract_has_math":false,"creators":["Leary, Frank J."],"institution":"Creighton University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Struck, Harold C."],"committee_chairs":[],"committee_members":[],"year":1953,"date_issued":"1953","date_published":"1953","updated_at":"2026-07-24T01:51:30Z","subjects":[],"languages":["en_US"],"rights":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10504/115998","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Struck, Harold C."]},{"key":"dc:creator","label":"Author","values":["Leary, Frank J."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-01-30T23:07:03Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-01-30T23:07:03Z"]},{"key":"dc:date.issued","label":"Date","values":["1953"]},{"key":"dc:publisher","label":"Institution","values":["Creighton University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10504/115998"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The hemolytic action of methylene blue was reported in 1924 by Huyghabaert. Doge developed anemia following the admlnistration of the dye and methylene blue was shown to produce hemolysis in vitro (l). In 1934, Wendel and Hefley observed the hemolytic property of the dye and suggested its use in the treatment of polycythemia (2). Olivier, in 1939, reported a ease of polycythemia which he treated with methylene blue. A reduction in the patient's red blood cell count was obtained but further studies were impossible when the patient became lost in the confusion of the war (3). Investigation of methylene blue as a chemotherapeutic agent again revealed its hemolytic action. Mice were successfully treated with the dye for Tsutsugamushi disease but subsequently developed anemia (4)."]},{"key":"dc:title","label":"Title","values":["The Influence of Certain Lytic Agents on the Oxygen Consumption of Dog Erythrocytes"]}]}],"canonical_facts":{"dc:contributor.advisor":["Struck, Harold C."],"dc:creator":["Leary, Frank J."],"dc:date.accessioned":["2018-01-30T23:07:03Z"],"dc:date.available":["2018-01-30T23:07:03Z"],"dc:date.issued":["1953"],"dc:description.abstract":["The hemolytic action of methylene blue was reported in 1924 by Huyghabaert. Doge developed anemia following the admlnistration of the dye and methylene blue was shown to produce hemolysis in vitro (l). In 1934, Wendel and Hefley observed the hemolytic property of the dye and suggested its use in the treatment of polycythemia (2). Olivier, in 1939, reported a ease of polycythemia which he treated with methylene blue. A reduction in the patient's red blood cell count was obtained but further studies were impossible when the patient became lost in the confusion of the war (3). Investigation of methylene blue as a chemotherapeutic agent again revealed its hemolytic action. Mice were successfully treated with the dye for Tsutsugamushi disease but subsequently developed anemia (4)."],"dc:identifier.uri":["http://hdl.handle.net/10504/115998"],"dc:language.iso":["en_US"],"dc:publisher":["Creighton University"],"dc:rights":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."],"dc:title":["The Influence of Certain Lytic Agents on the Oxygen Consumption of Dog Erythrocytes"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T01:51:30Z"}