Mesotheliomata

In 1870 Wagner (1) first described a tubercle-like lymphadenoma of the pleura which Schulz (2) later re-examined and described as endothelial carcinoma. Many case reports, chiefly in the German literature, have appeared since that time; Saccone and Coblenz (1943) (3) found over 200 references in the literature. Included in this number are the many reviews which have appeared from time to time : Glöckner (1987) (4), Block (1905 (5), Clarkson (1914) (6), Robertson (1924) (7), Geschickter (1936) (8), and others. | The early history of the tumor has been so completely covered by Robertson (1924) (7) that it will not be repeated here. However, in reviewing the literature of this period, the reader immediately is aware of the complete discord of terminology, description and theory that is to be found. In consequence, a controversy has arisen concerning the histogenesis of diffuse mesothelialomas which has continued until the present time. As Klemperer and Rabin ( 9 ) have noted, much of this confusion has resulted from the reports of wide variation in appearance of these tumors both grossly and microscopically that have been reported. Many authors believe that the point of origin is the sub- epithelial lymphatics, while others contend the origin is in the subserous connective tissue. We agree with those who hold that the superficial lining cells (mésothélium) may undergo malignant change, and produce true diffuse tumors. | A wide variety of names has been proposed for tumors arising from the serosal lining tissues. Endothelial carcinoma, endothelioma, sarcoma, carcinoma, sarcocarcinoma, and lymphangitis proliferans are the titles most often encountered.

Grantor dc:publisher

Creighton University

Year dc:date.issued

1949

Author dc:creator

• Reals, William Joseph

Advisor dc:contributor.advisor

• Russum, B. Carl

Statement dc:rights

• A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/10504/115990

OAI identifier oai:identifier

oai:cdr.creighton.edu:10504/115990