{"id":{"repo_id":"creighton","oai_identifier":"oai:cdr.creighton.edu:10504/114404"},"canonical_url":"https://search.dev.ndltd.org/etd/creighton/oai:cdr.creighton.edu:10504/114404","repository":{"repo_id":"creighton","name":"Creighton University","base_url":"https://cdr.creighton.edu/server/oai/request"},"display":{"title":"Mechanisms of Pteridine-Ommochrome Interactions in Drosophila Melanogaster","abstract":"Ommochromes (brown pigments) and certain pteridines (red pigments), contribute to the typical reddish-brown eye color of wild-type Drosophila melanogaster. Each pigment is the end product of a seemingly unrelated metabolic pathway (Ziegler 1961; Kaufman 1967a). Mutations which alter the synthesis of these pigments are manifested as numerous variations in eye color (Lindsley and Grell 1967). Suppressed production of brown pigment results in the accumulation of ommochrome precursors which in some instances alters the production of drosopterins and their intermediates. \"Pteridine mutants\" accumulate pteridine intermediates and show altered ommochrome formation (Hadorn and Mitchell 1951) . Therefore, an interaction between the two biosynthetic pathways is indicated.","abstract_html":"Ommochromes (brown pigments) and certain pteridines (red pigments), contribute to the typical reddish-brown eye color of wild-type Drosophila melanogaster. Each pigment is the end product of a seemingly unrelated metabolic pathway (Ziegler 1961; Kaufman 1967a). Mutations which alter the synthesis of these pigments are manifested as numerous variations in eye color (Lindsley and Grell 1967). Suppressed production of brown pigment results in the accumulation of ommochrome precursors which in some instances alters the production of drosopterins and their intermediates. "Pteridine mutants" accumulate pteridine intermediates and show altered ommochrome formation (Hadorn and Mitchell 1951) . Therefore, an interaction between the two biosynthetic pathways is indicated.","abstract_has_math":false,"creators":["Cirone Jr., Joseph B."],"institution":"Creighton University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Nickla, Harry"],"committee_chairs":[],"committee_members":[],"year":1974,"date_issued":"1974","date_published":"1974","updated_at":"2026-07-24T01:50:46Z","subjects":["Drosophila Melanogaster"],"languages":["en_US"],"rights":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10504/114404","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Nickla, Harry"]},{"key":"dc:creator","label":"Author","values":["Cirone Jr., Joseph B."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-10-03T21:18:38Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-10-03T21:18:38Z"]},{"key":"dc:date.issued","label":"Date","values":["1974"]},{"key":"dc:publisher","label":"Institution","values":["Creighton University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Drosophila Melanogaster"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10504/114404"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Ommochromes (brown pigments) and certain pteridines (red pigments), contribute to the typical reddish-brown eye color of wild-type Drosophila melanogaster. Each pigment is the end product of a seemingly unrelated metabolic pathway (Ziegler 1961; Kaufman 1967a). Mutations which alter the synthesis of these pigments are manifested as numerous variations in eye color (Lindsley and Grell 1967). Suppressed production of brown pigment results in the accumulation of ommochrome precursors which in some instances alters the production of drosopterins and their intermediates. \"Pteridine mutants\" accumulate pteridine intermediates and show altered ommochrome formation (Hadorn and Mitchell 1951) . Therefore, an interaction between the two biosynthetic pathways is indicated."]},{"key":"dc:title","label":"Title","values":["Mechanisms of Pteridine-Ommochrome Interactions in Drosophila Melanogaster"]}]}],"canonical_facts":{"dc:contributor.advisor":["Nickla, Harry"],"dc:creator":["Cirone Jr., Joseph B."],"dc:date.accessioned":["2017-10-03T21:18:38Z"],"dc:date.available":["2017-10-03T21:18:38Z"],"dc:date.issued":["1974"],"dc:description.abstract":["Ommochromes (brown pigments) and certain pteridines (red pigments), contribute to the typical reddish-brown eye color of wild-type Drosophila melanogaster. Each pigment is the end product of a seemingly unrelated metabolic pathway (Ziegler 1961; Kaufman 1967a). Mutations which alter the synthesis of these pigments are manifested as numerous variations in eye color (Lindsley and Grell 1967). Suppressed production of brown pigment results in the accumulation of ommochrome precursors which in some instances alters the production of drosopterins and their intermediates. \"Pteridine mutants\" accumulate pteridine intermediates and show altered ommochrome formation (Hadorn and Mitchell 1951) . Therefore, an interaction between the two biosynthetic pathways is indicated."],"dc:identifier.uri":["http://hdl.handle.net/10504/114404"],"dc:language.iso":["en_US"],"dc:publisher":["Creighton University"],"dc:rights":["A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above."],"dc:subject":["Drosophila Melanogaster"],"dc:title":["Mechanisms of Pteridine-Ommochrome Interactions in Drosophila Melanogaster"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T01:50:46Z"}