{"id":{"repo_id":"cornell","oai_identifier":"oai:ecommons.cornell.edu:1813/116002"},"canonical_url":"https://search.dev.ndltd.org/etd/cornell/oai:ecommons.cornell.edu:1813/116002","repository":{"repo_id":"cornell","name":"Cornell University","base_url":"https://ecommons.cornell.edu/server/oai/request"},"display":{"title":"Engineering Collagen Nanostructure to Enable Stiff & Tough Cartilage Biomaterials","abstract":"Collagen is the main component of extracellular matrices (ECM) throughout the body, and the main structural component of cartilage tissue. As such, collagen has been widely investigated as a biomaterial for tissue engineering. However, the process of extracting collagen and processing it to form functional materials has failed to recapitulate the mechanical and structural properties of native tissue.To best understand the potential uses for collagen biomaterials for cartilage tissue engineering, the characteristics of cartilage throughout the body and the clinical standard for cartilage repair were evaluated (Chapter 1) Then, to address the variety of species and tissue sources, and processing methods on the performance of collagen biomaterials, the impact on composition and telopeptides on the mechanics and nanostructure of collagen were investigated (Chapter 2). In the first of two applications of collagen as a biomaterial for cartilage tissue engineering in this work, collagen was then investigated as part of a biohybrid composite system where the addition of collagen vastly improved both the mechanical performance and cytocompatability of the material (Chapter 3). Finally, collagen was functinalized with alginate to enable metal-ion complexation in order to improve the extensibility and toughness of the material, with the effect of seeding with auricular chondrocytes on fracture toughness of the material tracked with a custom analytical framework (Chapter 4)","abstract_html":"Collagen is the main component of extracellular matrices (ECM) throughout the body, and the main structural component of cartilage tissue. As such, collagen has been widely investigated as a biomaterial for tissue engineering. However, the process of extracting collagen and processing it to form functional materials has failed to recapitulate the mechanical and structural properties of native tissue.To best understand the potential uses for collagen biomaterials for cartilage tissue engineering, the characteristics of cartilage throughout the body and the clinical standard for cartilage repair were evaluated (Chapter 1) Then, to address the variety of species and tissue sources, and processing methods on the performance of collagen biomaterials, the impact on composition and telopeptides on the mechanics and nanostructure of collagen were investigated (Chapter 2). In the first of two applications of collagen as a biomaterial for cartilage tissue engineering in this work, collagen was then investigated as part of a biohybrid composite system where the addition of collagen vastly improved both the mechanical performance and cytocompatability of the material (Chapter 3). Finally, collagen was functinalized with alginate to enable metal-ion complexation in order to improve the extensibility and toughness of the material, with the effect of seeding with auricular chondrocytes on fracture toughness of the material tracked with a custom analytical framework (Chapter 4)","abstract_has_math":false,"creators":["Slyker, Leigh"],"institution":"Cornell University","degree_name":"Ph. D., Biomedical Engineering","degree_level":"Doctor of Philosophy","degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":["Vacanti, Nathaniel","Putnam, David"],"year":2024,"date_issued":"2024-05","date_published":"2024-05","updated_at":"2026-07-24T01:48:58Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.7298/7gsf-1422"],"render_values":[{"text":"https://doi.org/10.7298/7gsf-1422","href":"https://doi.org/10.7298/7gsf-1422","code":true}]},{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["ProQuest Submission ID: 14157","ProQuest Publication ID: 30992602"],"render_values":[{"text":"ProQuest Submission ID: 14157","href":null,"code":true},{"text":"ProQuest Publication ID: 30992602","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/1813/116002","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Vacanti, Nathaniel","Putnam, David"]},{"key":"dc:creator","label":"Author","values":["Slyker, Leigh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-11-05T19:47:16Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-11-05T19:47:16Z"]},{"key":"dc:date.issued","label":"Date","values":["2024-05"]},{"key":"dc:type","label":"Dc Type","values":["dissertation or thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctor of Philosophy"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph. 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As such, collagen has been widely investigated as a biomaterial for tissue engineering. However, the process of extracting collagen and processing it to form functional materials has failed to recapitulate the mechanical and structural properties of native tissue.To best understand the potential uses for collagen biomaterials for cartilage tissue engineering, the characteristics of cartilage throughout the body and the clinical standard for cartilage repair were evaluated (Chapter 1) Then, to address the variety of species and tissue sources, and processing methods on the performance of collagen biomaterials, the impact on composition and telopeptides on the mechanics and nanostructure of collagen were investigated (Chapter 2). In the first of two applications of collagen as a biomaterial for cartilage tissue engineering in this work, collagen was then investigated as part of a biohybrid composite system where the addition of collagen vastly improved both the mechanical performance and cytocompatability of the material (Chapter 3). Finally, collagen was functinalized with alginate to enable metal-ion complexation in order to improve the extensibility and toughness of the material, with the effect of seeding with auricular chondrocytes on fracture toughness of the material tracked with a custom analytical framework (Chapter 4)"]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Engineering Collagen Nanostructure to Enable Stiff & Tough Cartilage Biomaterials"]}]}],"canonical_facts":{"dc:contributor.committeemember":["Vacanti, Nathaniel","Putnam, David"],"dc:creator":["Slyker, Leigh"],"dc:date.accessioned":["2024-11-05T19:47:16Z"],"dc:date.available":["2024-11-05T19:47:16Z"],"dc:date.issued":["2024-05"],"dc:description":["201 pages"],"dc:description.abstract":["Collagen is the main component of extracellular matrices (ECM) throughout the body, and the main structural component of cartilage tissue. As such, collagen has been widely investigated as a biomaterial for tissue engineering. However, the process of extracting collagen and processing it to form functional materials has failed to recapitulate the mechanical and structural properties of native tissue.To best understand the potential uses for collagen biomaterials for cartilage tissue engineering, the characteristics of cartilage throughout the body and the clinical standard for cartilage repair were evaluated (Chapter 1) Then, to address the variety of species and tissue sources, and processing methods on the performance of collagen biomaterials, the impact on composition and telopeptides on the mechanics and nanostructure of collagen were investigated (Chapter 2). In the first of two applications of collagen as a biomaterial for cartilage tissue engineering in this work, collagen was then investigated as part of a biohybrid composite system where the addition of collagen vastly improved both the mechanical performance and cytocompatability of the material (Chapter 3). Finally, collagen was functinalized with alginate to enable metal-ion complexation in order to improve the extensibility and toughness of the material, with the effect of seeding with auricular chondrocytes on fracture toughness of the material tracked with a custom analytical framework (Chapter 4)"],"dc:format.mimetype":["application/pdf"],"dc:identifier.doi":["https://doi.org/10.7298/7gsf-1422"],"dc:identifier.other":["ProQuest Submission ID: 14157","ProQuest Publication ID: 30992602"],"dc:identifier.uri":["https://hdl.handle.net/1813/116002"],"dc:language.iso":["en"],"dc:title":["Engineering Collagen Nanostructure to Enable Stiff & Tough Cartilage Biomaterials"],"dc:type":["dissertation or thesis"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_level":["Doctor of Philosophy"],"thesis:degree_name":["Ph. D., Biomedical Engineering"],"thesis:institution_name":["Cornell University"]},"updated_at":"2026-07-24T01:48:58Z"}