{"id":{"repo_id":"cornell","oai_identifier":"oai:ecommons.cornell.edu:1813/115826"},"canonical_url":"https://search.dev.ndltd.org/etd/cornell/oai:ecommons.cornell.edu:1813/115826","repository":{"repo_id":"cornell","name":"Cornell University","base_url":"https://ecommons.cornell.edu/server/oai/request"},"display":{"title":"Micro-Pipette Aspiration for Hyperelastic and Poroelastic Material","abstract":"Micro-pipette aspiration technique is a widely used, non-destructive experimental method to determine the mechanical properties of cells and tissues. This experimentation is performed with the assumption of cells pertaining fluid-like characteristics, and the surface tension is determined through the mechanical response of the cell being deformed. In this work, living cells are described with the properties of hyperelasticity and poroelasticity, to study the response of these materials under the loading conditions of aspiration. The work put forth, builds on complexities by considering geometric non-linearities of contact between the continuum and the pipette, leading to understanding the effects of surface energy on continuum possessing hyperelasticity. This consideration highlights the variation in stiffness of the continuum with applied pressure, parameterized by elastocapillarity length scale. The reaction forces experienced by the continuum due to contact are also illustrated before incorporating the characteristics of poroelasticity, into mixed finite element formulation. The transition of stress, chemical potential and concentration of continuum exhibiting poroelasticity is presented. Lastly, the effects of surface energy on the continuum resembling living cells, characterized by poroelasticity are studied.","abstract_html":"Micro-pipette aspiration technique is a widely used, non-destructive experimental method to determine the mechanical properties of cells and tissues. This experimentation is performed with the assumption of cells pertaining fluid-like characteristics, and the surface tension is determined through the mechanical response of the cell being deformed. In this work, living cells are described with the properties of hyperelasticity and poroelasticity, to study the response of these materials under the loading conditions of aspiration. The work put forth, builds on complexities by considering geometric non-linearities of contact between the continuum and the pipette, leading to understanding the effects of surface energy on continuum possessing hyperelasticity. This consideration highlights the variation in stiffness of the continuum with applied pressure, parameterized by elastocapillarity length scale. The reaction forces experienced by the continuum due to contact are also illustrated before incorporating the characteristics of poroelasticity, into mixed finite element formulation. The transition of stress, chemical potential and concentration of continuum exhibiting poroelasticity is presented. Lastly, the effects of surface energy on the continuum resembling living cells, characterized by poroelasticity are studied.","abstract_has_math":false,"creators":["Joshi, Sarvesh"],"institution":"Cornell University","degree_name":"M.S., Mechanical Engineering","degree_level":"Master of Science","degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":["Hui, Chung-Yuen"],"year":2024,"date_issued":"2024-05","date_published":"2024-05","updated_at":"2026-07-24T01:48:58Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.7298/vteb-my54"],"render_values":[{"text":"https://doi.org/10.7298/vteb-my54","href":"https://doi.org/10.7298/vteb-my54","code":true}]},{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["ProQuest Submission ID: 12104","ProQuest Publication ID: 31243365"],"render_values":[{"text":"ProQuest Submission ID: 12104","href":null,"code":true},{"text":"ProQuest Publication ID: 31243365","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/1813/115826","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Hui, Chung-Yuen"]},{"key":"dc:creator","label":"Author","values":["Joshi, Sarvesh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-11-05T19:42:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-11-05T19:42:41Z"]},{"key":"dc:date.issued","label":"Date","values":["2024-05"]},{"key":"dc:type","label":"Dc Type","values":["dissertation or thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Master of Science"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S., Mechanical Engineering"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Cornell University"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.7298/vteb-my54"]},{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["ProQuest Submission ID: 12104","ProQuest Publication ID: 31243365"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/1813/115826"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["68 pages"]},{"key":"dc:description.abstract","label":"Abstract","values":["Micro-pipette aspiration technique is a widely used, non-destructive experimental method to determine the mechanical properties of cells and tissues. This experimentation is performed with the assumption of cells pertaining fluid-like characteristics, and the surface tension is determined through the mechanical response of the cell being deformed. In this work, living cells are described with the properties of hyperelasticity and poroelasticity, to study the response of these materials under the loading conditions of aspiration. The work put forth, builds on complexities by considering geometric non-linearities of contact between the continuum and the pipette, leading to understanding the effects of surface energy on continuum possessing hyperelasticity. This consideration highlights the variation in stiffness of the continuum with applied pressure, parameterized by elastocapillarity length scale. The reaction forces experienced by the continuum due to contact are also illustrated before incorporating the characteristics of poroelasticity, into mixed finite element formulation. The transition of stress, chemical potential and concentration of continuum exhibiting poroelasticity is presented. Lastly, the effects of surface energy on the continuum resembling living cells, characterized by poroelasticity are studied."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Micro-Pipette Aspiration for Hyperelastic and Poroelastic Material"]}]}],"canonical_facts":{"dc:contributor.committeemember":["Hui, Chung-Yuen"],"dc:creator":["Joshi, Sarvesh"],"dc:date.accessioned":["2024-11-05T19:42:41Z"],"dc:date.available":["2024-11-05T19:42:41Z"],"dc:date.issued":["2024-05"],"dc:description":["68 pages"],"dc:description.abstract":["Micro-pipette aspiration technique is a widely used, non-destructive experimental method to determine the mechanical properties of cells and tissues. This experimentation is performed with the assumption of cells pertaining fluid-like characteristics, and the surface tension is determined through the mechanical response of the cell being deformed. In this work, living cells are described with the properties of hyperelasticity and poroelasticity, to study the response of these materials under the loading conditions of aspiration. The work put forth, builds on complexities by considering geometric non-linearities of contact between the continuum and the pipette, leading to understanding the effects of surface energy on continuum possessing hyperelasticity. This consideration highlights the variation in stiffness of the continuum with applied pressure, parameterized by elastocapillarity length scale. The reaction forces experienced by the continuum due to contact are also illustrated before incorporating the characteristics of poroelasticity, into mixed finite element formulation. The transition of stress, chemical potential and concentration of continuum exhibiting poroelasticity is presented. Lastly, the effects of surface energy on the continuum resembling living cells, characterized by poroelasticity are studied."],"dc:format.mimetype":["application/pdf"],"dc:identifier.doi":["https://doi.org/10.7298/vteb-my54"],"dc:identifier.other":["ProQuest Submission ID: 12104","ProQuest Publication ID: 31243365"],"dc:identifier.uri":["https://hdl.handle.net/1813/115826"],"dc:language.iso":["en"],"dc:title":["Micro-Pipette Aspiration for Hyperelastic and Poroelastic Material"],"dc:type":["dissertation or thesis"],"thesis:degree_discipline":["Mechanical Engineering"],"thesis:degree_level":["Master of Science"],"thesis:degree_name":["M.S., Mechanical Engineering"],"thesis:institution_name":["Cornell University"]},"updated_at":"2026-07-24T01:48:58Z"}