Optical spectroscopy for biological and biomedical applications: potentially impacting future of healthcare with research, clinical translation and education
type: CreativeWork
description: Clinical interventions have been significantly improved by recent advances in devices for disease detection, monitoring, diagnosis and surgical guidance. However, most of the current imaging technologies provide primarily morphological/structural information on analyzed subjects or samples, which is insufficient to detect early-stage diseases and identify tissue structures with enough contrast. Optical spectroscopy and imaging can solve this insufficiency by providing molecular-sensitive tools for applications involving screening, diagnosis, monitoring vital signs, treatment planning and guidance, treatment-outcome prediction, and others. These tools provide non-invasive, real-time, cost-effective, and in situ interrogation of biological samples. Key advantages can be added to optical tools upon their miniaturization and integration into existing medical instruments, wearables and portable test kits, as patient prognosis can be improved by increasing the contrast of identification between vital structures and tissues to be resected, as well as by enabling telehealth solutions via remote monitoring individual health status. Such identification and monitoring can be achieved by extracting information on sample microstructure, biochemistry, and associated quantities. The thesis investigates the feasibility of using optical spectroscopy as an optical technique for application in cancer detection and delineation, specifications of next generation optical devices for this application, as well as tissue microstructural and biochemical features associated with carcinogenesis and organ viability for transplantation. Previous studies cover the selection and optimization optical techniques for a limited number of applications and parameters. Most studies of this thesis optimize diffuse reflectance spectroscopy (DRS) parameters for colorectal and organ preservation applications, while instruments developed for other optical techniques and associated analysis methods can be used…
abstract: Clinical interventions have been significantly improved by recent advances in devices for disease detection, monitoring, diagnosis and surgical guidance. However, most of the current imaging technologies provide primarily morphological/structural information on analyzed subjects or samples, which is insufficient to detect early-stage diseases and identify tissue structures with enough contrast. Optical spectroscopy and imaging can solve this insufficiency by providing molecular-sensitive tools for applications involving screening, diagnosis, monitoring vital signs, treatment planning and guidance, treatment-outcome prediction, and others. These tools provide non-invasive, real-time, cost-effective, and in situ interrogation of biological samples. Key advantages can be added to optical tools upon their miniaturization and integration into existing medical instruments, wearables and portable test kits, as patient prognosis can be improved by increasing the contrast of identification between vital structures and tissues to be resected, as well as by enabling telehealth solutions via remote monitoring individual health status. Such identification and monitoring can be achieved by extracting information on sample microstructure, biochemistry, and associated quantities. The thesis investigates the feasibility of using optical spectroscopy as an optical technique for application in cancer detection and delineation, specifications of next generation optical devices for this application, as well as tissue microstructural and biochemical features associated with carcinogenesis and organ viability for transplantation. Previous studies cover the selection and optimization optical techniques for a limited number of applications and parameters. Most studies of this thesis optimize diffuse reflectance spectroscopy (DRS) parameters for colorectal and organ preservation applications, while instruments developed for other optical techniques and associated analysis methods can be used…
author: Saito Nogueira, Marcelo
language: en
keywords: Biomedical optics, Biophotonics education, Multidisciplinary, Diffuse reflectance spectroscopy, Oral cancer, Colorectal cancer, Near-infrared spectroscopy, Endoscopy, Laparoscopy, Colonoscopy, MedTech, Healthcare, HealthTech, DeepTech, Machine learning, TeleHealth, Intestinal anastomosis, Optical treatments, Phototherapy, Photodynamic therapy, Fluorescence spectroscopy, Fluorescence lifetime spectroscopy, Time-resolved spectroscopy, Time-domain optical spectroscopy, Frequency domain diffuse optical spectroscopy, Optical frequency-domain imaging, Monte Carlo simulations, Light tissue interactions, Optical imaging, Microscopy, Stochastic modelling, Light propagation in complex media, Innovation, Commercialization, Policy making, Gastrointestinal cancer, Medical technology, Digital health, STEM education, Artificial intelligence, Data processing, Multivariate analysis, Statistical analysis, Spatial frequency domain imaging, Tissue optics
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
date published: 2021-11-10
date modified: 2026-07-24T01:47:55Z
provider: University College Cork
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University College Cork

PropertyValue
property ID: Handle
value: https://hdl.handle.net/10468/14150