Correlation of Aqueous Solubility and Anti-Cancer Activity of Novel Triazolium and Imidazolium Salts

<p>Novel triazolium, imidazolium, and benzimidazolium salts are known to possess anti-cancer properties and have potential as cancer therapeutics. This thesis describes the aqueous solubility and the differential activity of N,AT-bis-substituted-l,2,4-triazolium bromide salts and N/N'-bis(naphthylmethyl)imidazolium bromide salts against MDA-MB-468 breast cancer cells and PC-3 prostate carcinomas. Using a microscale technique, the partition coefficient (log P) of each salt was determined. The log P value was explored to determine the bioavailability of each derivative.</p>

Name thesis:degree_name

Chemistry

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Chemistry

Year dc:date.available

2018

Author dc:creator

• Bies, Jared J.

Contributors dc:contributor

• Dr. Jonathan Meyers
• Dr. Kerri Taylor
• Dr. Cindy Ticknor

• Aqueous Solubility
• Anti-Cancer
• Novel Triazolium Salts
• Imidazolium Salts
• Cancer Therapeutics
• Benzimidazolium Salts
• Chemistry
• Medicinal-Pharmaceutical Chemistry

Language dc:language

English

Repository record dc:identifier

https://csuepress.columbusstate.edu/theses_dissertations/338

OAI identifier oai:identifier

oai:csuepress.columbusstate.edu:theses_dissertations-1340