Aspergillus fumigalus is a ubiquitous fungus that causes an infection called aspergillosis in immune-compromised surgery patients (Latge, 2001, 384; Bok et al. 2006). Aspergillosis cases have increased in the past decade due to the increasing number of patients undergoing immunosuppressive therapy and receiving organ transplants (Bok et al. 2006). Although there is still disagreement as to the causative agent of the symptoms accompanying aspergillosis, many scientists suspect that the compound, gliotoxin, plays a major role, hi this study, we compared the amounts of gliotoxin produced from clinical and environmental isolates of A. fumigatus. We hypothesized that the amount of gliotoxin produced would be higher in the clinical isolates in comparison to the environmental isolates. Cell assay results showed that the clinical isolates produced more gliotoxin than the environmental isolates while the HPLC results showed no significant difference between gliotoxin production in clinical and environmental isolates.
","abstract_html":"<p>Aspergillus fumigalus is a ubiquitous fungus that causes an infection called aspergillosis in immune-compromised surgery patients (Latge, 2001, 384; Bok et al. 2006). Aspergillosis cases have increased in the past decade due to the increasing number of patients undergoing immunosuppressive therapy and receiving organ transplants (Bok et al. 2006). Although there is still disagreement as to the causative agent of the symptoms accompanying aspergillosis, many scientists suspect that the compound, gliotoxin, plays a major role, hi this study, we compared the amounts of gliotoxin produced from clinical and environmental isolates of A. fumigatus. We hypothesized that the amount of gliotoxin produced would be higher in the clinical isolates in comparison to the environmental isolates. Cell assay results showed that the clinical isolates produced more gliotoxin than the environmental isolates while the HPLC results showed no significant difference between gliotoxin production in clinical and environmental isolates.</p>","abstract_has_math":false,"creators":["Musyimi, Susan"],"institution":null,"degree_name":"Biology","degree_level":"Thesis","degree_discipline":"Biology","degree_department":null,"school":null,"contributors":["Milwood Motley"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008-01-01T08:00:00Z","date_published":"2008-01-01T08:00:00Z","updated_at":"2026-07-24T01:44:48Z","subjects":["Aspergillus Fumigatus","Immunosuppressive Therapy","Immune-Compromised","Gliotoxin","HPLC","Biological Phenomena, Cell Phenomena, and Immunity","Biology","Immunotherapy","Medical Immunology"],"languages":["English"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://csuepress.columbusstate.edu/theses_dissertations/132","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Milwood Motley"]},{"key":"dc:creator","label":"Author","values":["Musyimi, Susan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2015-10-13T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Biology"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Aspergillus Fumigatus","Immunosuppressive Therapy","Immune-Compromised","Gliotoxin","HPLC","Biological Phenomena, Cell Phenomena, and Immunity","Biology","Immunotherapy","Medical Immunology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://csuepress.columbusstate.edu/theses_dissertations/132"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Aspergillus fumigalus is a ubiquitous fungus that causes an infection called aspergillosis in immune-compromised surgery patients (Latge, 2001, 384; Bok et al. 2006). Aspergillosis cases have increased in the past decade due to the increasing number of patients undergoing immunosuppressive therapy and receiving organ transplants (Bok et al. 2006). Although there is still disagreement as to the causative agent of the symptoms accompanying aspergillosis, many scientists suspect that the compound, gliotoxin, plays a major role, hi this study, we compared the amounts of gliotoxin produced from clinical and environmental isolates of A. fumigatus. We hypothesized that the amount of gliotoxin produced would be higher in the clinical isolates in comparison to the environmental isolates. Cell assay results showed that the clinical isolates produced more gliotoxin than the environmental isolates while the HPLC results showed no significant difference between gliotoxin production in clinical and environmental isolates.
"]},{"key":"dc:title","label":"Title","values":["Gliotoxin Production in Aspergillus fumigatus"]}]}],"canonical_facts":{"dc:contributor":["Milwood Motley"],"dc:creator":["Musyimi, Susan"],"dc:date.available":["2015-10-13T07:00:00Z"],"dc:description.abstract":["Aspergillus fumigalus is a ubiquitous fungus that causes an infection called aspergillosis in immune-compromised surgery patients (Latge, 2001, 384; Bok et al. 2006). Aspergillosis cases have increased in the past decade due to the increasing number of patients undergoing immunosuppressive therapy and receiving organ transplants (Bok et al. 2006). Although there is still disagreement as to the causative agent of the symptoms accompanying aspergillosis, many scientists suspect that the compound, gliotoxin, plays a major role, hi this study, we compared the amounts of gliotoxin produced from clinical and environmental isolates of A. fumigatus. We hypothesized that the amount of gliotoxin produced would be higher in the clinical isolates in comparison to the environmental isolates. Cell assay results showed that the clinical isolates produced more gliotoxin than the environmental isolates while the HPLC results showed no significant difference between gliotoxin production in clinical and environmental isolates.
"],"dc:identifier":["https://csuepress.columbusstate.edu/theses_dissertations/132"],"dc:language":["English"],"dc:subject":["Aspergillus Fumigatus","Immunosuppressive Therapy","Immune-Compromised","Gliotoxin","HPLC","Biological Phenomena, Cell Phenomena, and Immunity","Biology","Immunotherapy","Medical Immunology"],"dc:title":["Gliotoxin Production in Aspergillus fumigatus"],"thesis:degree_discipline":["Biology"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Biology"]},"updated_at":"2026-07-24T01:44:48Z"}