Dynamic Digital Optical Tomography for Cancer Imaging and Therapy Monitoring

Diffuse optical tomography is a non-invasive imaging technique that uses near-infrared light to create three-dimensional images of tissue. This dissertation presents the design and validation of an instrument for rapid optical imaging using digital detection techniques. In addition to a detailed description of the instrument, three studies are presented: a clinical study detecting breast cancer using dynamic optical imaging; a pre-clinical study monitoring early tumor response to anti-angiogenic therapy; and a clinical study monitoring individual patient response to neoadjuvant chemotherapy. These studies show that diffuse optical tomography is a valuable imaging modality that can play an important role in cancer detection and treatment.

Author dc:creator

• Flexman, Molly

• Biomedical engineering
• Optical tomography
• Breast--Cancer--Treatment
• Neovascularization inhibitors
• Cancer--Chemotherapy

Language dc:language

English

DOI dc:identifier

https://doi.org/10.7916/D8JD540P

OAI identifier oai:identifier

oai:academiccommons.columbia.edu:10.7916/D8JD540P