Coffee consumption increases risk of advanced breast cancer among Singapore Chinese women
type: CreativeWork
description: Background: Experimental data support both a protective and risk enhancing effect of coffee compounds on breast cancer development. A few retrospective studies conducted before 1988 also reported inconsistent findings. However, more recent prospective epidemiological data do not support a relationship between coffee intake and breast cancer risk among western populations, and well-conducted studies among Asian population are lacking. Coffee is one of the most commonly consumed beverages, but more among western populations than most Asian populations. In Singapore with relatively recent economic development, aspects of western diet and lifestyle, including coffee consumption, have become more prevalent. Even though the breast cancer incidence rate kept increasing in Singapore during last three decades, it is still much lower than western countries. Since many contributing factors (such as diet and lifestyle) to the lower risk profile among Asian women compared with US women, conducting prospective studies on evaluating the association between coffee intake and breast cancer risk among this Asian population help us have opportunity to observe the breast cancer-coffee association if there is one, among this lower breast cancer profile population. Objective: To evaluate the effect of coffee consumption and overall caffeine intake on breast cancer incidence among women in the Singapore Health Study. To achieve this objective, we have the following analysis strategies: 1) Evaluate the effect of coffee consumption and overall caffeine intake on breast cancer incidence; 2) Restrict the analysis to the subgroup group: late stage breast cancer cases (metastatic or ≥5cm or present in lymph nodes vs. localized disease), since we only observed the statistically significant findings among the advanced disease cases; 3) Conduct subgroup analysis by estrogen/progesterone receptor (ER/PR) status; 4) Conduct stratified analyses by potential effect modifier: below and above median BMI…
abstract: Background: Experimental data support both a protective and risk enhancing effect of coffee compounds on breast cancer development. A few retrospective studies conducted before 1988 also reported inconsistent findings. However, more recent prospective epidemiological data do not support a relationship between coffee intake and breast cancer risk among western populations, and well-conducted studies among Asian population are lacking. Coffee is one of the most commonly consumed beverages, but more among western populations than most Asian populations. In Singapore with relatively recent economic development, aspects of western diet and lifestyle, including coffee consumption, have become more prevalent. Even though the breast cancer incidence rate kept increasing in Singapore during last three decades, it is still much lower than western countries. Since many contributing factors (such as diet and lifestyle) to the lower risk profile among Asian women compared with US women, conducting prospective studies on evaluating the association between coffee intake and breast cancer risk among this Asian population help us have opportunity to observe the breast cancer-coffee association if there is one, among this lower breast cancer profile population. Objective: To evaluate the effect of coffee consumption and overall caffeine intake on breast cancer incidence among women in the Singapore Health Study. To achieve this objective, we have the following analysis strategies: 1) Evaluate the effect of coffee consumption and overall caffeine intake on breast cancer incidence; 2) Restrict the analysis to the subgroup group: late stage breast cancer cases (metastatic or ≥5cm or present in lymph nodes vs. localized disease), since we only observed the statistically significant findings among the advanced disease cases; 3) Conduct subgroup analysis by estrogen/progesterone receptor (ER/PR) status; 4) Conduct stratified analyses by potential effect modifier: below and above median BMI…
author: Zhu, Lei, author
author: Bachand, Annette, advisor
author: Butler, Lesley, advisor
author: Nelson-Ceschin, Tracy, committee member
language: eng
language: English
keywords: advanced disease, coffee, caffeine, breast cancer, body mass index
date published: 2013
date modified: 2026-07-27T19:13:09Z
provider: Colorado State University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Colorado State University. Libraries

PropertyValue
property ID: Handle
value: http://hdl.handle.net/10217/79212

PropertyValue
property ID: DOI
value: 10.25675/3.018648