In-vivo investigation of resveratrol as a preventive for radiation-induced acute myeloid leukemia

Resveratrol has been shown to have cancer preventive properties. It modulates a wide range of molecular targets including those involved with induction of apoptosis and cell cycle arrest in a concentration dependent fashion. This study was designed to investigate resveratrol's ability to reduce radiation-induced chromosome aberrations and PU.1 gene loss in mouse bone marrow cells. Loss of 1 PU.1 gene and missense mutation of the remaining allele leads to acute myeloid leukemia in CBA mice.

Name thesis:degree_name

Doctor of Philosophy (Ph.D.)

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Cell and Molecular Biology

Grantor dc:publisher

Colorado State University. Libraries

Year dc:date.issued

2008

Authors dc:creator

• Carsten, Ronald E., author
• Ullrich, Robert L., advisor

• acute myeloid leukemia
• resveratrol
• molecular biology
• cellular biology
• medicine
• oncology

Statement dc:rights

• Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.

Language dc:language.iso

eng, English

Identifier URI

https://doi.org/10.25675/3.018999

OAI identifier oai:identifier

oai:mountainscholar.org:10217/237628