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In the second project discussed, we have successfully pursued the synthesis of numerous, biologically active analogs of the natural product (+)-largazole. Synthetic efforts have led to the design of inhibitors with unprecedented biological activity, as well as providing information regarding the structure-activity relationship of these molecules."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["doctoral dissertations"]},{"key":"dc:title","label":"Title","values":["Towards the total synthesis of 14-acetoxygelsenicine and synthesis of largazole analogs"]}]}],"canonical_facts":{"dc:creator":["Newkirk, Tenaya L., author","Williams, Robert M., advisor","Stermitz, Frank R., committee member","Ferreira, Eric M., committee member","Rickey, Dawn, committee member","Thamm, Douglas H., committee member"],"dc:date.accessioned":["2022-11-28T17:46:48Z"],"dc:date.available":["2022-11-28T17:46:48Z"],"dc:date.issued":["2009"],"dc:description.abstract":["Herein are documented our efforts in two projects, beginning with studies towards the total synthesis of 14-acetoxygelsenicine. 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