In good heart”: a study of the factors associated with health- related quality of life in adult congenital heart disease.
type: CreativeWork
description: Aims: The overall aim of the thesis is to study the Health-Related Quality of Life (HRQoL) in Adult Congenital Heart Disease (ACHD). The thesis examines the impact of ACHD on HRQoL, the demographic, clinical, and psychosocial factors associated with HRQoL, and changes in these factors over time. Methods: The thesis consists of three studies, including a cross-sectional, a longitudinal, and a qualitative. Three hundred and fourteen individuals, from four diagnostic groups (Simple, Tetralogy of Fallot-ToF, Transposition of the Great Arteries-TGA, & Single Ventricle-SV) were recruited from The Heart Hospital, London and completed the cross-sectional study. Clinical measures were collected by a consultant cardiologist and participants completed a range of psychosocial measures, including generic and disease-specific measures of HRQoL. One-sample t-tests were conducted to examine differences between the whole sample and diagnostic groups and general population norms and ANOVAs for differences between the four diagnostic groups in HRQoL. Hierarchical multiple regressions were employed to examine the factors associated with HRQoL. One hundred and eighty eight participants completed the longitudinal study (mean follow-up: 3.3 years). Changes in HRQoL and other psychosocial variables were explored using Hierarchical Linear Models (HLM). Semi-structured interviews were conducted with twelve participants to explore their experiences. Results: Participants reported diminished HRQoL in some physical and psychosocial domains. The SV group reported poorer physical and psychosocial HRQoL in various domains compared with the general population norms and some of the other diagnostic groups, whilst the Simple group reported impaired psychosocial HRQoL. Illness perceptions explained the largest proportion of variance in generic (physical and psychosocial) and disease-specific HRQoL. After accounting for demographic and clinical characteristics, psychosocial factors including perception…
abstract: Aims: The overall aim of the thesis is to study the Health-Related Quality of Life (HRQoL) in Adult Congenital Heart Disease (ACHD). The thesis examines the impact of ACHD on HRQoL, the demographic, clinical, and psychosocial factors associated with HRQoL, and changes in these factors over time. Methods: The thesis consists of three studies, including a cross-sectional, a longitudinal, and a qualitative. Three hundred and fourteen individuals, from four diagnostic groups (Simple, Tetralogy of Fallot-ToF, Transposition of the Great Arteries-TGA, & Single Ventricle-SV) were recruited from The Heart Hospital, London and completed the cross-sectional study. Clinical measures were collected by a consultant cardiologist and participants completed a range of psychosocial measures, including generic and disease-specific measures of HRQoL. One-sample t-tests were conducted to examine differences between the whole sample and diagnostic groups and general population norms and ANOVAs for differences between the four diagnostic groups in HRQoL. Hierarchical multiple regressions were employed to examine the factors associated with HRQoL. One hundred and eighty eight participants completed the longitudinal study (mean follow-up: 3.3 years). Changes in HRQoL and other psychosocial variables were explored using Hierarchical Linear Models (HLM). Semi-structured interviews were conducted with twelve participants to explore their experiences. Results: Participants reported diminished HRQoL in some physical and psychosocial domains. The SV group reported poorer physical and psychosocial HRQoL in various domains compared with the general population norms and some of the other diagnostic groups, whilst the Simple group reported impaired psychosocial HRQoL. Illness perceptions explained the largest proportion of variance in generic (physical and psychosocial) and disease-specific HRQoL. After accounting for demographic and clinical characteristics, psychosocial factors including perception…
author: Fteropoulli, Theodora
keywords: R Medicine
date published: 2016
date modified: 2026-07-24T01:39:27Z
provider: City University of London
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: City University London