Flow effect on thrombus formation in stenosed coronary arteries: a computational study
type: CreativeWork
description: Thrombotic complications often occur in stenosed coronary artery, causing permanent damage and even death. Although the exact factors and events leading to thrombus formation are not entirely known, the local rheological conditions as well as the different tendency for clotting of the blood of each individual are considered to have an important role both in progress of the disease and the relevant complications. Recently a statistical correlation between the exact location of the stenosis and the evolution of the disease has been reported [1]. In this work we investigated whether this connection can be predicted by computational simulations. For this purpose, a simplified model for blood coagulation, focusing mainly on thrombin activation, has been formulated in three steps. A phenomenological sub-model for thrombin generation was developed and calibrated, based on clinical tests (not laboratory experiments). The model was proved capable of reproducing with acceptable accuracy the rate of thrombin generation for blood samples from individuals with different thrombogenic potential, including haemophilia cases. A second sub-model for platelet aggregation on reacting surface was developed and calibrated in order to reproduce experimental data [2]. Finally, the whole coagulation model was adapted for application under flow conditions, based on the threshold behaviour of blood coagulation under flow in respect to wall shear rate and reacting surface stream-wise length [3]. In order to test the developed models, 3 groups of left anterior descending (LAD) geometry models have been constructed based on the location of the stenotic lesion. Each group consisted by geometries with different degrees of stenosis. Two of these groups (named MI1 and MI2) were statistically assessed as of higher risk for complications with the third one (STA) considered safer. Transient flow simulations were performed for these three groups, with representative coronary flow conditions. Flow was re…
abstract: Thrombotic complications often occur in stenosed coronary artery, causing permanent damage and even death. Although the exact factors and events leading to thrombus formation are not entirely known, the local rheological conditions as well as the different tendency for clotting of the blood of each individual are considered to have an important role both in progress of the disease and the relevant complications. Recently a statistical correlation between the exact location of the stenosis and the evolution of the disease has been reported [1]. In this work we investigated whether this connection can be predicted by computational simulations. For this purpose, a simplified model for blood coagulation, focusing mainly on thrombin activation, has been formulated in three steps. A phenomenological sub-model for thrombin generation was developed and calibrated, based on clinical tests (not laboratory experiments). The model was proved capable of reproducing with acceptable accuracy the rate of thrombin generation for blood samples from individuals with different thrombogenic potential, including haemophilia cases. A second sub-model for platelet aggregation on reacting surface was developed and calibrated in order to reproduce experimental data [2]. Finally, the whole coagulation model was adapted for application under flow conditions, based on the threshold behaviour of blood coagulation under flow in respect to wall shear rate and reacting surface stream-wise length [3]. In order to test the developed models, 3 groups of left anterior descending (LAD) geometry models have been constructed based on the location of the stenotic lesion. Each group consisted by geometries with different degrees of stenosis. Two of these groups (named MI1 and MI2) were statistically assessed as of higher risk for complications with the third one (STA) considered safer. Transient flow simulations were performed for these three groups, with representative coronary flow conditions. Flow was re…
author: Papadopoulos, Konstantinos
keywords: QA75 Electronic computers. Computer science, R Medicine (General)
date published: 2015
date modified: 2026-07-24T01:39:24Z
provider: City University of London
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: City University London