Thermally Responsive Peptide Coated Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery
type: CreativeWork
description: Target specific delivery of anticancer drugs to the effected site without showing systematic toxicity to normal tissues is important. Multifunctional biodegradable delivery systems reduce systematic toxicity in an efficient manner. These drug carriers should provide controlled release, be directed towards desired site, track payloads via contrast imaging, heat the effected sites and trigger drug release. In this context, superparamagnetic iron oxide nanoparticles based drug delivery systems are highly desirable. Superparamagnetic iron oxide nanoparticles upon exposure of alternate magnetic field could be directed and provide heat to localised areas. Moreover, superparamagnetic iron oxide nanoparticles also have image contrast ability for magnetic resonance imaging. This study aimed to develop biocompatible superparamagnetic iron oxide nanoparticles. These nanoparticles were coated by bioinspired materials such as peptides (diphenylalanine) to achieve monodispersed dual efficient such as drug carriers and hyperthermia. Thermally responsive core-shell materials with tubular and spherical morphologies without compromising the inner cores properties such as superparamagnetism is highly desirable. Two shapes of iron oxide (spherical and tubular) were prepared using co-precipitation of iron (II) and (III) ion and oxidative hydrolysis of ferrous sulphate in alkaline solutions, respectively. Spherical peptide shells were synthesised using tert-Butyloxycarbonyl modified diphenylalanine peptide in ethanol-water (1:1) mixture. Tubular peptide shells were prepared using similar diphenylalanine non-modified peptide. The iron oxide nanoparticles (spherical and tubular) were encapsulated via template-mediated synthesis using ultra-sonication and vortex-mixing methods. These materials were characterised using variety of techniques such as, zetasizer, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDAX), Fourier Transform Infrared Spectroscopy (FTIR), Brun…
abstract: Target specific delivery of anticancer drugs to the effected site without showing systematic toxicity to normal tissues is important. Multifunctional biodegradable delivery systems reduce systematic toxicity in an efficient manner. These drug carriers should provide controlled release, be directed towards desired site, track payloads via contrast imaging, heat the effected sites and trigger drug release. In this context, superparamagnetic iron oxide nanoparticles based drug delivery systems are highly desirable. Superparamagnetic iron oxide nanoparticles upon exposure of alternate magnetic field could be directed and provide heat to localised areas. Moreover, superparamagnetic iron oxide nanoparticles also have image contrast ability for magnetic resonance imaging. This study aimed to develop biocompatible superparamagnetic iron oxide nanoparticles. These nanoparticles were coated by bioinspired materials such as peptides (diphenylalanine) to achieve monodispersed dual efficient such as drug carriers and hyperthermia. Thermally responsive core-shell materials with tubular and spherical morphologies without compromising the inner cores properties such as superparamagnetism is highly desirable. Two shapes of iron oxide (spherical and tubular) were prepared using co-precipitation of iron (II) and (III) ion and oxidative hydrolysis of ferrous sulphate in alkaline solutions, respectively. Spherical peptide shells were synthesised using tert-Butyloxycarbonyl modified diphenylalanine peptide in ethanol-water (1:1) mixture. Tubular peptide shells were prepared using similar diphenylalanine non-modified peptide. The iron oxide nanoparticles (spherical and tubular) were encapsulated via template-mediated synthesis using ultra-sonication and vortex-mixing methods. These materials were characterised using variety of techniques such as, zetasizer, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDAX), Fourier Transform Infrared Spectroscopy (FTIR), Brun…
author: Majid, Abdul
language: en
keywords: F100 - Chemistry
date published: 2017-08
date modified: 2026-07-24T01:36:16Z
provider: University of Central Lancashire
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Central Lancashire