Prevalence and treatment of painful diabetic neuropathy
type: CreativeWork
description: The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. The reported prevalence of PDN varies from 11% in Rochester, Minnesota, USA to 53.7% in the Middle East. One UK study, published in 2011, reported that the prevalence of PDN was 21.5% in type 2 diabetes patients and 13.4% in type 1 diabetes patients, resulting in an overall prevalence of 21%. Numerous studies have found cardiovascular risk factors—including increased age, longer duration of diabetes, higher weight, smoking, poor glycaemic control, renal impairment and high cholesterol—to be associated with PDN. This disorder has a huge effect on people’s daily lives both physically and mentally. Despite huge advances in medicine, the treatment of PDN is both challenging for physicians and distressing for patients. In this thesis, three studies were carried out on the following topics: prevalence and characteristics of painful diabetic neuropathy, PDN patients’ quality of life, and treatment employing lignocaine. This first study assessed the prevalence of painful diabetic neuropathy (PDN) and its relationship with various cardiovascular characteristics in diabetes subjects. This was done through an observational study of diabetes subjects in Northwest England, UK (n =204). The self-completed Leeds Assessment of Neuropathic Symptoms and Signs questionnaire was sent by post to the subjects and used to diagnose PDN. Consent for participation and access to blood results was given by the study participants. Ethical approval for the study was also granted by National Research Ethics Committee UK. The results of the study showed that the crude prevalence of PDN among subjects was 30.3%. The prevalence of type 2 diabetes subjects was higher (33.1 %) than that of type 1 diabetes subject…
abstract: The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. The reported prevalence of PDN varies from 11% in Rochester, Minnesota, USA to 53.7% in the Middle East. One UK study, published in 2011, reported that the prevalence of PDN was 21.5% in type 2 diabetes patients and 13.4% in type 1 diabetes patients, resulting in an overall prevalence of 21%. Numerous studies have found cardiovascular risk factors—including increased age, longer duration of diabetes, higher weight, smoking, poor glycaemic control, renal impairment and high cholesterol—to be associated with PDN. This disorder has a huge effect on people’s daily lives both physically and mentally. Despite huge advances in medicine, the treatment of PDN is both challenging for physicians and distressing for patients. In this thesis, three studies were carried out on the following topics: prevalence and characteristics of painful diabetic neuropathy, PDN patients’ quality of life, and treatment employing lignocaine. This first study assessed the prevalence of painful diabetic neuropathy (PDN) and its relationship with various cardiovascular characteristics in diabetes subjects. This was done through an observational study of diabetes subjects in Northwest England, UK (n =204). The self-completed Leeds Assessment of Neuropathic Symptoms and Signs questionnaire was sent by post to the subjects and used to diagnose PDN. Consent for participation and access to blood results was given by the study participants. Ethical approval for the study was also granted by National Research Ethics Committee UK. The results of the study showed that the crude prevalence of PDN among subjects was 30.3%. The prevalence of type 2 diabetes subjects was higher (33.1 %) than that of type 1 diabetes subject…
author: Aslam, Amir
language: en
date published: 2014-08
date modified: 2026-07-24T01:35:49Z
provider: University of Central Lancashire
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Central Lancashire