{"id":{"repo_id":"cau-kiel","oai_identifier":"oai:macau.uni-kiel.de:macau_mods_00008842"},"canonical_url":"https://search.dev.ndltd.org/etd/cau-kiel/oai:macau.uni-kiel.de:macau_mods_00008842","repository":{"repo_id":"cau-kiel","name":"Christian-Albrechts Universität Kiel","base_url":"https://macau.uni-kiel.de/servlets/OAIDataProvider"},"display":{"title":"Natural product chemistry in drug discovery","abstract":"This thesis examines two interrelated aspects of natural product research: the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three publications. The first is a literature review of structure-dependent activity among plant-derived compounds active against methicillin-resistant Staphylococcus aureus (MRSA). It links reported antibacterial activities to structural features, identifies molecular motifs associated with anti-MRSA efficacy, and proposes lead structures for further investigation. The second reports the isolation of flavonoids and sesquiterpene lactones from Lychnophora ericoides, a plant used in traditional medicine, and their evaluation against multiple myeloma and acute myeloid leukemia cell lines. Several compounds show first evidence of cytotoxic activity, exemplifying the classical natural product drug discovery workflow of species selection, isolation, structure elucidation, and bioassay. The third addresses source verification in pharmacognosy. It demonstrates that furanocoumarins previously reported from Cicerbita alpina originated instead from Peucedanum ostruthium roots present in a mixed plant collection, correcting the phytochemical record and preventing the misattribution of a potentially harmful compound class to a species consumed in the Italian Alps. Together, the three publications illustrate the interdependence of chemical structure, biological activity, and biological origin in natural product research, and underscore the need for rigorous taxonomic and chemical authentication alongside bioactivity-guided discovery.","abstract_html":"This thesis examines two interrelated aspects of natural product research: the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three publications. The first is a literature review of structure-dependent activity among plant-derived compounds active against methicillin-resistant Staphylococcus aureus (MRSA). It links reported antibacterial activities to structural features, identifies molecular motifs associated with anti-MRSA efficacy, and proposes lead structures for further investigation. The second reports the isolation of flavonoids and sesquiterpene lactones from Lychnophora ericoides, a plant used in traditional medicine, and their evaluation against multiple myeloma and acute myeloid leukemia cell lines. Several compounds show first evidence of cytotoxic activity, exemplifying the classical natural product drug discovery workflow of species selection, isolation, structure elucidation, and bioassay. The third addresses source verification in pharmacognosy. It demonstrates that furanocoumarins previously reported from Cicerbita alpina originated instead from Peucedanum ostruthium roots present in a mixed plant collection, correcting the phytochemical record and preventing the misattribution of a potentially harmful compound class to a species consumed in the Italian Alps. Together, the three publications illustrate the interdependence of chemical structure, biological activity, and biological origin in natural product research, and underscore the need for rigorous taxonomic and chemical authentication alongside bioactivity-guided discovery.","abstract_has_math":false,"creators":["Moreno Cardenas, Calisto"],"institution":"Christian-Albrechts-Universität zu Kiel","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Zidorn, Christian","Çiçek, Serhat Sezai"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-07-15","date_published":"2026-07-15","updated_at":"2026-07-24T01:35:26Z","subjects":["Bioactivities","MRSA","Lychnophora ericoides","Cicerbita alpina","Peucedanum ostruthium","Acute myeloid leukemia","Multiple myeloma","Chemophenetics","Furanocoumarine"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://macau.uni-kiel.de/receive/macau_mods_00008842","outbound_label":"Repository record","outbound_source":"source_url"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Zidorn, Christian","Çiçek, Serhat Sezai"]},{"key":"dc:creator","label":"Author","values":["Moreno Cardenas, Calisto"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Universitätsbibliothek Kiel"]},{"key":"dc:type","label":"Dc Type","values":["PhDThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Christian-Albrechts-Universität zu Kiel"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Bioactivities","MRSA","Lychnophora ericoides","Cicerbita alpina","Peucedanum ostruthium","Acute myeloid leukemia","Multiple myeloma","Chemophenetics","Furanocoumarine"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This thesis examines two interrelated aspects of natural product research: the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three publications. The first is a literature review of structure-dependent activity among plant-derived compounds active against methicillin-resistant Staphylococcus aureus (MRSA). It links reported antibacterial activities to structural features, identifies molecular motifs associated with anti-MRSA efficacy, and proposes lead structures for further investigation. The second reports the isolation of flavonoids and sesquiterpene lactones from Lychnophora ericoides, a plant used in traditional medicine, and their evaluation against multiple myeloma and acute myeloid leukemia cell lines. Several compounds show first evidence of cytotoxic activity, exemplifying the classical natural product drug discovery workflow of species selection, isolation, structure elucidation, and bioassay. The third addresses source verification in pharmacognosy. It demonstrates that furanocoumarins previously reported from Cicerbita alpina originated instead from Peucedanum ostruthium roots present in a mixed plant collection, correcting the phytochemical record and preventing the misattribution of a potentially harmful compound class to a species consumed in the Italian Alps. Together, the three publications illustrate the interdependence of chemical structure, biological activity, and biological origin in natural product research, and underscore the need for rigorous taxonomic and chemical authentication alongside bioactivity-guided discovery."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Natural product chemistry in drug discovery"]}]}],"canonical_facts":{"dc:contributor":["Zidorn, Christian","Çiçek, Serhat Sezai"],"dc:creator":["Moreno Cardenas, Calisto"],"dc:description.abstract":["This thesis examines two interrelated aspects of natural product research: the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three publications. The first is a literature review of structure-dependent activity among plant-derived compounds active against methicillin-resistant Staphylococcus aureus (MRSA). It links reported antibacterial activities to structural features, identifies molecular motifs associated with anti-MRSA efficacy, and proposes lead structures for further investigation. The second reports the isolation of flavonoids and sesquiterpene lactones from Lychnophora ericoides, a plant used in traditional medicine, and their evaluation against multiple myeloma and acute myeloid leukemia cell lines. Several compounds show first evidence of cytotoxic activity, exemplifying the classical natural product drug discovery workflow of species selection, isolation, structure elucidation, and bioassay. The third addresses source verification in pharmacognosy. It demonstrates that furanocoumarins previously reported from Cicerbita alpina originated instead from Peucedanum ostruthium roots present in a mixed plant collection, correcting the phytochemical record and preventing the misattribution of a potentially harmful compound class to a species consumed in the Italian Alps. Together, the three publications illustrate the interdependence of chemical structure, biological activity, and biological origin in natural product research, and underscore the need for rigorous taxonomic and chemical authentication alongside bioactivity-guided discovery."],"dc:format.medium":["application/pdf"],"dc:publisher":["Universitätsbibliothek Kiel"],"dc:subject":["Bioactivities","MRSA","Lychnophora ericoides","Cicerbita alpina","Peucedanum ostruthium","Acute myeloid leukemia","Multiple myeloma","Chemophenetics","Furanocoumarine"],"dc:title":["Natural product chemistry in drug discovery"],"dc:type":["PhDThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Christian-Albrechts-Universität zu Kiel"]},"updated_at":"2026-07-24T01:35:26Z"}