{"id":{"repo_id":"cau-kiel","oai_identifier":"oai:macau.uni-kiel.de:macau_mods_00008550"},"canonical_url":"https://search.dev.ndltd.org/etd/cau-kiel/oai:macau.uni-kiel.de:macau_mods_00008550","repository":{"repo_id":"cau-kiel","name":"Christian-Albrechts Universität Kiel","base_url":"https://macau.uni-kiel.de/servlets/OAIDataProvider"},"display":{"title":"Small non-coding RNA-mediated epigenetic regulation of gene expression and its implications for wheat adaptation to continuous cultivation","abstract":"Winter wheat (Triticum aestivum L.) is one of the most important staple crops worldwide. However, continuous wheat cultivation often leads to yield decline which poses a serious threat to sustainable wheat production. This yield decline is generally attributed to the interaction of abiotic and biotic soil stress factors as well as plant adaptation to long-term monoculture systems. However, the underlying molecular mechanisms have not yet been adequately explained. Against this background, this dissertation presents, in addition to a general introduction (Chapter I) and discussion (Chapter V), three research papers that deal with the mechanisms of plant adaptation to continuous cultivation. Chapter II entitled \"RNA-directed DNA methylation (RdDM) modulates the trade-off between growth and defense and contributes to wheat adaptation to continuous cultivation\" investigates the possible contribution of epigenetic modifications to wheat adaptation to long-term continuous cultivation. Chapter III entitled \"MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) facilitate the adaptation of wheat (Triticum aestivum L.) to continuous cultivation\" demonstrates that both miRNAs and 24-nt siRNAs are strongly affected by continuous cultivation and act as key regulators of wheat molecular and physiological processes. Chapter IV entitled \"The microRNA Bna-miR1885 interferes with TIR-NLRs and modulates the plant defense response in model plant Arabidopsis thaliana\" focuses on the functional characterization of a Brassica-specific miR1885 in model plant Arabidopsis thaliana. In conclusion, this work shows that both RdDM pathway and miRNA-mediated post-transcriptional gene regulation activate changes in gene expression and physiological processes in plants. This leads to a shift in the balance between growth and defense. Limited energy and resource reserves are increasingly allocated to stress responses, ultimately resulting in a loss of yield. These findings substantially broaden our understanding of plant adaptive strategies at the epigenetic and post-transcriptional levels and provide valuable candidate genes, small RNAs, and epialleles for improving crop tolerance by e.g., targeted breeding or genome-editing approaches.","abstract_html":"Winter wheat (Triticum aestivum L.) is one of the most important staple crops worldwide. However, continuous wheat cultivation often leads to yield decline which poses a serious threat to sustainable wheat production. This yield decline is generally attributed to the interaction of abiotic and biotic soil stress factors as well as plant adaptation to long-term monoculture systems. However, the underlying molecular mechanisms have not yet been adequately explained. Against this background, this dissertation presents, in addition to a general introduction (Chapter I) and discussion (Chapter V), three research papers that deal with the mechanisms of plant adaptation to continuous cultivation. Chapter II entitled "RNA-directed DNA methylation (RdDM) modulates the trade-off between growth and defense and contributes to wheat adaptation to continuous cultivation" investigates the possible contribution of epigenetic modifications to wheat adaptation to long-term continuous cultivation. Chapter III entitled "MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) facilitate the adaptation of wheat (Triticum aestivum L.) to continuous cultivation" demonstrates that both miRNAs and 24-nt siRNAs are strongly affected by continuous cultivation and act as key regulators of wheat molecular and physiological processes. Chapter IV entitled "The microRNA Bna-miR1885 interferes with TIR-NLRs and modulates the plant defense response in model plant Arabidopsis thaliana" focuses on the functional characterization of a Brassica-specific miR1885 in model plant Arabidopsis thaliana. In conclusion, this work shows that both RdDM pathway and miRNA-mediated post-transcriptional gene regulation activate changes in gene expression and physiological processes in plants. This leads to a shift in the balance between growth and defense. Limited energy and resource reserves are increasingly allocated to stress responses, ultimately resulting in a loss of yield. These findings substantially broaden our understanding of plant adaptive strategies at the epigenetic and post-transcriptional levels and provide valuable candidate genes, small RNAs, and epialleles for improving crop tolerance by e.g., targeted breeding or genome-editing approaches.","abstract_has_math":false,"creators":["Han, Lingyue"],"institution":"Christian-Albrechts-Universität zu Kiel","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Cai, Daguang","Kage, Henning"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-05-20","date_published":"2026-05-20","updated_at":"2026-07-24T01:35:26Z","subjects":["wheat yield decline","continuous cultivation","plant adaptation","miRNA","siRNA","RdDM","TGS and PTGS","gene regulation","trade-offs"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://macau.uni-kiel.de/receive/macau_mods_00008550","outbound_label":"Repository record","outbound_source":"source_url"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Cai, Daguang","Kage, Henning"]},{"key":"dc:creator","label":"Author","values":["Han, Lingyue"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Universitätsbibliothek Kiel"]},{"key":"dc:type","label":"Dc Type","values":["PhDThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Christian-Albrechts-Universität zu Kiel"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["wheat yield decline","continuous cultivation","plant adaptation","miRNA","siRNA","RdDM","TGS and PTGS","gene regulation","trade-offs"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Winter wheat (Triticum aestivum L.) is one of the most important staple crops worldwide. However, continuous wheat cultivation often leads to yield decline which poses a serious threat to sustainable wheat production. This yield decline is generally attributed to the interaction of abiotic and biotic soil stress factors as well as plant adaptation to long-term monoculture systems. However, the underlying molecular mechanisms have not yet been adequately explained. Against this background, this dissertation presents, in addition to a general introduction (Chapter I) and discussion (Chapter V), three research papers that deal with the mechanisms of plant adaptation to continuous cultivation. Chapter II entitled \"RNA-directed DNA methylation (RdDM) modulates the trade-off between growth and defense and contributes to wheat adaptation to continuous cultivation\" investigates the possible contribution of epigenetic modifications to wheat adaptation to long-term continuous cultivation. Chapter III entitled \"MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) facilitate the adaptation of wheat (Triticum aestivum L.) to continuous cultivation\" demonstrates that both miRNAs and 24-nt siRNAs are strongly affected by continuous cultivation and act as key regulators of wheat molecular and physiological processes. Chapter IV entitled \"The microRNA Bna-miR1885 interferes with TIR-NLRs and modulates the plant defense response in model plant Arabidopsis thaliana\" focuses on the functional characterization of a Brassica-specific miR1885 in model plant Arabidopsis thaliana. In conclusion, this work shows that both RdDM pathway and miRNA-mediated post-transcriptional gene regulation activate changes in gene expression and physiological processes in plants. This leads to a shift in the balance between growth and defense. Limited energy and resource reserves are increasingly allocated to stress responses, ultimately resulting in a loss of yield. These findings substantially broaden our understanding of plant adaptive strategies at the epigenetic and post-transcriptional levels and provide valuable candidate genes, small RNAs, and epialleles for improving crop tolerance by e.g., targeted breeding or genome-editing approaches."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Small non-coding RNA-mediated epigenetic regulation of gene expression and its implications for wheat adaptation to continuous cultivation"]}]}],"canonical_facts":{"dc:contributor":["Cai, Daguang","Kage, Henning"],"dc:creator":["Han, Lingyue"],"dc:description.abstract":["Winter wheat (Triticum aestivum L.) is one of the most important staple crops worldwide. However, continuous wheat cultivation often leads to yield decline which poses a serious threat to sustainable wheat production. This yield decline is generally attributed to the interaction of abiotic and biotic soil stress factors as well as plant adaptation to long-term monoculture systems. However, the underlying molecular mechanisms have not yet been adequately explained. Against this background, this dissertation presents, in addition to a general introduction (Chapter I) and discussion (Chapter V), three research papers that deal with the mechanisms of plant adaptation to continuous cultivation. Chapter II entitled \"RNA-directed DNA methylation (RdDM) modulates the trade-off between growth and defense and contributes to wheat adaptation to continuous cultivation\" investigates the possible contribution of epigenetic modifications to wheat adaptation to long-term continuous cultivation. Chapter III entitled \"MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) facilitate the adaptation of wheat (Triticum aestivum L.) to continuous cultivation\" demonstrates that both miRNAs and 24-nt siRNAs are strongly affected by continuous cultivation and act as key regulators of wheat molecular and physiological processes. Chapter IV entitled \"The microRNA Bna-miR1885 interferes with TIR-NLRs and modulates the plant defense response in model plant Arabidopsis thaliana\" focuses on the functional characterization of a Brassica-specific miR1885 in model plant Arabidopsis thaliana. In conclusion, this work shows that both RdDM pathway and miRNA-mediated post-transcriptional gene regulation activate changes in gene expression and physiological processes in plants. This leads to a shift in the balance between growth and defense. Limited energy and resource reserves are increasingly allocated to stress responses, ultimately resulting in a loss of yield. These findings substantially broaden our understanding of plant adaptive strategies at the epigenetic and post-transcriptional levels and provide valuable candidate genes, small RNAs, and epialleles for improving crop tolerance by e.g., targeted breeding or genome-editing approaches."],"dc:format.medium":["application/pdf"],"dc:publisher":["Universitätsbibliothek Kiel"],"dc:subject":["wheat yield decline","continuous cultivation","plant adaptation","miRNA","siRNA","RdDM","TGS and PTGS","gene regulation","trade-offs"],"dc:title":["Small non-coding RNA-mediated epigenetic regulation of gene expression and its implications for wheat adaptation to continuous cultivation"],"dc:type":["PhDThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Christian-Albrechts-Universität zu Kiel"]},"updated_at":"2026-07-24T01:35:26Z"}