Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
type: CreativeWork
description: The nervous system is the most complex system of our body. It is divided into peripheral (PNS) and central nervous system (CNS), the latter being composed of the brain and spinal cord that constitute the control center of all functions body. The brain microenvironment, essential for its normal function, is ensured by the blood–brain barrier (BBB), a physical physiological barrier that represents the major obstacle to reach CNS. Due to this complex anatomy, most of the current therapeutic strategies remain ineffective for the CNS treatment. Nowadays, the incidence of CNS disorders has greatly increased and they represent a serious problem, not only concerning the high costs of treatment, but in addition, the quality of life of the patient. Among these, Alzheimer’s disease (AD) is a neurodegenerative disorder of which the main cause is a marked oxidative stress at the level of the encephalic cells. Recent studies indicate that the normalization of antioxidant capacity could represent a very promising therapeutic for the treatment of AD. Moreover, research has made a significant effort to develop innovative therapies based on natural compounds, as old synthetic drugs cause numerous side effects. Curcumin (CUR) and astaxanthin (AST) are two natural antioxidants that possess therapeutic properties for the treatment of AD, although they show poor biovailability due to their high lipophilicity. In order to overcome these limits that compromise their therapeutic use, the researchers' attention is focused on the development of innovative and efficient stealth carriers (sSLN) loaded with these antioxidants, capable of avoiding the defense line represented by the macrophages and improving the drug stability, in order to achieve good bioavailability in the brain. The best strategies to realize sSLN, suitable for parenteral administration, were to coat the CUR-SLN surface with hydrophilic polymer PEG (CUR-pSLN), while the AST-SLN with surfactant polysorbate 80 (AST-p80SLN). CUR-…
abstract: The nervous system is the most complex system of our body. It is divided into peripheral (PNS) and central nervous system (CNS), the latter being composed of the brain and spinal cord that constitute the control center of all functions body. The brain microenvironment, essential for its normal function, is ensured by the blood–brain barrier (BBB), a physical physiological barrier that represents the major obstacle to reach CNS. Due to this complex anatomy, most of the current therapeutic strategies remain ineffective for the CNS treatment. Nowadays, the incidence of CNS disorders has greatly increased and they represent a serious problem, not only concerning the high costs of treatment, but in addition, the quality of life of the patient. Among these, Alzheimer’s disease (AD) is a neurodegenerative disorder of which the main cause is a marked oxidative stress at the level of the encephalic cells. Recent studies indicate that the normalization of antioxidant capacity could represent a very promising therapeutic for the treatment of AD. Moreover, research has made a significant effort to develop innovative therapies based on natural compounds, as old synthetic drugs cause numerous side effects. Curcumin (CUR) and astaxanthin (AST) are two natural antioxidants that possess therapeutic properties for the treatment of AD, although they show poor biovailability due to their high lipophilicity. In order to overcome these limits that compromise their therapeutic use, the researchers' attention is focused on the development of innovative and efficient stealth carriers (sSLN) loaded with these antioxidants, capable of avoiding the defense line represented by the macrophages and improving the drug stability, in order to achieve good bioavailability in the brain. The best strategies to realize sSLN, suitable for parenteral administration, were to coat the CUR-SLN surface with hydrophilic polymer PEG (CUR-pSLN), while the AST-SLN with surfactant polysorbate 80 (AST-p80SLN). CUR-…
author: SANTONOCITO, DEBORA CONCETTA
language: ita
keywords: Lipid nanoparticles, Stealth nanoparticles, Central Nervous System, Natural compounds, Parenteral administration, Eye
date published: 2020-12-14
date modified: 2026-07-24T01:35:06Z
provider: Università degli Studi di Catania
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli studi di Catania

PropertyValue
property ID: Handle
value: https://hdl.handle.net/20.500.11769/581855