Electrical Impedance Spectroscopy with Multi-modal Tissue Discrimination for Ultrasound-Guided Targeted Biopsy

Prostate cancer diagnosis has undergone considerable evolution in recent years. Men with significant lesions observed via magnetic resonance imaging (MRI) typically undergo targeted biopsy. In a prostate biopsy procedure, ultrasound (US) is used to place a biopsy needle in lesion(s) identified via MRI for sampling. The lesion is not always visible in US, so proper needle placement is not guaranteed. Thus, false-negative results occur often, causing uncertainty in treatment. This thesis proposes an instrumented needle probe that uses electrical impedance spectroscopy to identify tissue at the needle tip in real-time, validated on an ex-vivo tissue dataset. Two data augmentation methods are proposed for improving classifiers trained on small datasets. Lastly, the thesis shows the ultrasonic vibrational potential can be measured with the probe and may provide information for tissue characterisation. The use of the probe for tissue identification could improve confidence in biopsy results and reduce procedure time.

Name thesis:degree_name

Master of Applied Science (M.App.Sc.)

Level thesis:degree_level

Master's

Discipline thesis:degree_discipline

Engineering, Biomedical

Grantor dc:publisher

Carleton University

Year dc:date.issued

2023

Author dc:creator

• McDermott, Conor

Statement dc:rights

• Copyright © 2023 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, distribution to students, research and scholarship. Theses may only be shared by linking to the Carleton University Institutional Repository and no part may be copied without proper attribution to the author; no part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.

Language dc:language.iso

en

DOI

10.22215/etd/2023-15979

OAI identifier oai:identifier

oai:carleton.scholaris.ca:20.500.14718/41295